不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制研究     

李洁  杨静  赵丽丽 《武汉体育学院学报》2019,53(5):88-94

目的：探讨不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制。方法：将雄性Wistar大鼠50只随机均分为5组：安静对照组（C）、低负荷运动训练组（LT）、中等负荷运动训练组（MT）、高负荷运动训练组（HT）和极高负荷运动训练组（ST），每组10只。各运动组分别进行6周的跑台运动训练。训练方案结束后，取腓肠肌样本，提取线粒体，测定线粒体柠檬酸合成酶（CS）、异柠檬酸脱氢酶（ICD）和α-酮戊二酸脱氢酶（α-KGDHC）活性；线粒体Ga²⁺含量、胞浆NADH、NAD⁺、ATP和ADP含量，以及ICD mRNA转录水平。结果：（1）不同负荷运动训练组线粒体CS、ICD和α-KGDHC的活性均显著高于安静对照组（P < 0.01），且CS和ICD活性由高到低顺序均为：MT组 > HT组 > ST组 > LT组 > C组，α-KGDHC活性由高到低顺序为：HT组 > MT组 > ST组 > LT组 > C组。（2）不同负荷运动训练组线粒体Ca²⁺ 含量均显著高于安静对照组（P < 0.01），其含量由高到低顺序为：MT组 > HT组 > ST组 > LT组 > C组；胞浆NADH/NAD⁺和ATP/ADP的比值均显著低于安静对照组（P < 0.01），其比值由低到高顺序为：MT组 < ST组 < HT组 < LT组 < C组。（3）不同负荷运动训练组ICD mRNA转录水平均高于安静对照组（P < 0.01），其水平由高到低顺序为： MT组 > HT组 > ST组 > LT组 > C组。结论：低负荷、中等负荷、高负荷及极高负荷运动训练均可提高大鼠骨骼肌线粒体三羧酸循环功能，且中等负荷运动训练效果最佳。其机制与胞浆NADH/NAD⁺和ATP/ADP比值、线粒体摄钙能力及限速酶基因的表达有关。  相似文献   

平行/重合D膜超势，Ooguri-Vafa不变量与类型II弦理论/F理论对偶     

蒋笑添  杨富中 《中国科学院大学学报》2019,36(5):590-597

利用类型Ⅱ弦理论/F理论对偶，第一次在平行和重合相区计算一个具体的双D膜系统的超势，并提取Ooguri-Vafa不变量。平行D膜相与重合D膜相间的相变也对应着D膜世界叶上规范理论规范对称性的提升U（1）×…×U（1）→U（n）。计算显示这两个相区的超势截然不同，并给出不同的Ooguri-Vafa不变量。这意味着相变的发生导致两个相区能谱结构的差异。  相似文献   

Examining the influence of grip type on wrist and club head kinematics during the golf swing: Benefits of a local co-ordinate system     

Howie J. Carson  Jim Richards  Bruno Mazuquin 《European Journal of Sport Science》2019,19(3):327-335

Wrist movements have been identified as an important factor in producing a successful golf swing, with their complex motion influencing both club head velocity and orientation. However, a detailed analysis of wrist angles is lacking in the literature. The purpose of this study was to determine kinematics across wrists and club head characteristics during the golf swing under weak, neutral and strong grip conditions. Twelve professional male golfers executed 24 shots using a driver under three grip conditions. A six degrees of freedom analysis of the hand with respect to the distal forearm was performed using a 10-camera three-dimensional motion capture system. Differences in joint angles were explored using repeated measures ANOVAs at key swing events (onset, top of backswing and impact), in addition club head velocity and clubface angle at impact were also explored. Main findings revealed significant differences in flexion/extension and internal/external rotation for both wrists at all swing events, whereas fewer significant interactions were found in ulnar/radial deviation across grips for both wrists at all events. Clubface angle only differed significantly between the weak and the strong and neural grips, presenting a more ‘open’ clubface to the intended hitting direction. This study is the first to explore tri-planar wrist movement and the effect of different grips, such analysis has implications for coaching knowledge and practice and should inform future research into different aspects of skill, technique analysis and may inform injury mechanisms/prevention.  相似文献   

“三个转型”综合改革：新时代世界一流体育大学发展的历史选择     

曹卫东 《北京体育大学学报》2019,42(1):17-22

摘要：新时代是我国发展新的历史方位，体育强国、教育强国、健康中国三大战略为世界一流体育大学提出了新的更高要求。为此，北京体育大学提出了“三个转型”综合改革，以推进世界一流体育大学建设和高水平竞技体育后备人才培养基地建设，为国家培养勇担新时代体育事业发展重任的优秀人才。为实现上述目标，应在深刻认识“三个转型”改革提出的背景基础上，深入理解“三个转型”的内涵与目标，全面推进“三个转型”综合改革，为新时代体育、教育事业贡献北京体育大学的力量。研究背景包括：1）新时代是“三个转型”的历史坐标，2）强国战略是“三个转型”的现实依据，3）创新模式是“三个转型”的客观需要；“三个转型”分别是：1）全面推进从传统经验型体育大学向现代科技型体育大学转型，2）从以夏季项目为主的体育大学向夏季冬季项目全面发展的体育大学转型，3）从本土化体育大学向国际化体育大学转型，其目的是实现两大办学目标：1）把北京体育大学建成中国高水平竞技体育后备人才培养基地，2）把北京体育大学建设成为世界一流体育大学；为了实现“三个转型”转型及其目标，必须准确把握“办大学与建基地、文化传承与科技创新、立足中国与放眼世界”三个维度及其核心关键问题。  相似文献   

聚力探索特色小镇 开辟体产全新格局——北京大学第9届中国体育产业高峰论坛综述     

赵雯婷  丁怡清  封英  张锐 《北京体育大学学报》2019,42(2):95-102

摘要：习近平总书记在十九大报告中出要广泛开展全民健身活动，加快推进体育强国建设。随着“健康中国”上升为国家战略、居民消费升级需求日益加深，我国运动休闲特色小镇的发展路径显得尤为重要。在此背景下，专家学者和业界名流齐聚北京大学，集思广益、畅所欲言，为特色小镇献计献策，共商特色小镇建设合作大计。此次中国体育产业高峰论坛分论坛以“运动休闲特色小镇”为主题，对运动休闲特色小镇这个概念进行了全方位、系统性的深刻剖析，并结合运动休闲特色小镇相关成功实践经验，从前期策划、设计、投资到后期的建设、运营，再到内容为王、跨界融合、聚集建构效应，多层次、多角度阐释了运动休闲特色小镇建构的内在机理和方法，为建设运动休闲特色小镇事业，开创全新体育文化产业格局提供了切实可行的路径。  相似文献   

基于Sentinel-1/2的水体提取方法对比研究——以斯里兰卡小型水体为例     

周晗  叶虎平  魏显虎  张宗科  王法溧  齐永菊  马建如 《中国科学院大学学报》2019,36(6):794-802

地表水面精确提取是研究地表水质和水量变化的重要基础。斯里兰卡是"21世纪海上丝绸之路"的重要参与国，年降雨量丰富，但时空分布不均，斯里兰卡人民长期用水困难，研究斯里兰卡地表水体有助于斯里兰卡民生问题的解决。斯里兰卡国内散布着大量的小型水库和坑塘，这些小面积水体易受周边环境因素影响而提取困难。基于2017年7月斯里兰卡中东部地区的哨兵（Sentinel）1/2号卫星影像，对比分析单波段法、水体指数法和监督分类等水体提取方法的精度和存在的问题。结果表明，归一化水体指数法NDWI的准确率最高，分类精度达94%。  相似文献   

Understanding the topic evolution of scientific literatures like an evolving city: Using Google Word2Vec model and spatial autocorrelation analysis     

Kai Hu  Qing Luo  Kunlun Qi  Siluo Yang  Jin Mao  Xiaokang Fu  Jie Zheng  Huayi Wu  Ya Guo  Qibing Zhu 《Information processing & management》2019,56(4):1185-1203

Topic evolution has been described by many approaches from a macro level to a detail level, by extracting topic dynamics from text in literature and other media types. However, why the evolution happens is less studied. In this paper, we focus on whether and how the keyword semantics can invoke or affect the topic evolution. We assume that the semantic relatedness among the keywords can affect topic popularity during literature surveying and citing process, thus invoking evolution. However, the assumption is needed to be confirmed in an approach that fully considers the semantic interactions among topics. Traditional topic evolution analyses in scientometric domains cannot provide such support because of using limited semantic meanings. To address this problem, we apply the Google Word2Vec, a deep learning language model, to enhance the keywords with more complete semantic information. We further develop the semantic space as an urban geographic space. We analyze the topic evolution geographically using the measures of spatial autocorrelation, as if keywords are the changing lands in an evolving city. The keyword citations (keyword citation counts one when the paper containing this keyword obtains a citation) are used as an indicator of keyword popularity. Using the bibliographical datasets of the geographical natural hazard field, experimental results demonstrate that in some local areas, the popularity of keywords is affecting that of the surrounding keywords. However, there are no significant impacts on the evolution of all keywords. The spatial autocorrelation analysis identifies the interaction patterns (including High-High leading, High-Low suppressing) among the keywords in local areas. This approach can be regarded as an analyzing framework borrowed from geospatial modeling. Moreover, the prediction results in local areas are demonstrated to be more accurate if considering the spatial autocorrelations.  相似文献   

Game-Based Learning in Virtual Worlds: A Multiuser Online Game for Medical Undergraduate Radiology Education within Second Life     

Rocio Lorenzo-Alvarez  Teodoro Rudolphi-Solero  Miguel J. Ruiz-Gomez  Francisco Sendra-Portero 《Anatomical sciences education》2020,13(5):602-617

Game-based learning can have a positive impact on medical education, and virtual worlds have great potential for supporting immersive online games. It is necessary to reinforce current medical students' knowledge about radiological anatomy and radiological signs. To meet this need, the objectives of this study were: to design a competition-based game in the virtual world, Second Life and to analyze the students' perceptions of Second Life and the game, as well as to analyze the medium-term retention of knowledge and the potential impact on the final grades. Ninety out of 197 (45.6%) third-year medical students voluntarily participated in an online game based on self-guided presentations and multiple-choice tests over six 6-day stages. Participants and non-participants were invited to perform an evaluation questionnaire about the experience and a post-exposure knowledge test. Participants rated the experience with mean scores equal to or higher than 8.1 on a 10-point scale, highlighting the professor (9.5 ± 1.1; mean ± SD) and the virtual environment (8.9 ± 1.1). Participants had better results in the post-exposure test than non-participants (59.0 ± 13.5 versus 45.3 ± 11.5; P < 0.001) and a lower percentage of answers left blank (6.7 ± 8.4 versus 13.1 ± 12.9; P = 0.014). Competitive game-based learning within Second Life is an effective and well-accepted means of teaching core radiological anatomy and radiological signs content to medical students. The higher medium-term outcomes obtained by participants may indicate effective learning with the game. Additionally, valuable positive perceptions about the game, the educational contents, and the potential benefit for their education were discovered among non-participants.  相似文献   

The impact of student misconceptions on student persistence in a MOOC     

Chen Chen  Gerhard Sonnert  Philip M. Sadler  Dimitar Sasselov  Colin Fredericks 《科学教学研究杂志》2020,57(6):879-910

Massive Online Open Courses (MOOCs) provide opportunities to learn a vast range of subjects. Because MOOCs are open to anyone with computer access and rarely have prerequisite requirements, the range of student backgrounds can be far more varied than in conventional classroom-based courses. Prior studies have shown that misconceptions have a huge impact on students' learning performance; however, no study has empirically examined the relationship between misconceptions and learning persistence. This study of 12,913 MOOC-takers examines how students' misconceptions about the upcoming course material affect course completion. Using a survival analysis approach, we found that, controlling for the score in a pre-course test, students holding more misconceptions had a higher dropout rate at the start of the course, an effect that diminished over time. Other student variables were found to have a positive impact on survival that persisted throughout the entire course: U.S. location, higher age, an intention to complete, better English skills, prior familiarity with the subject, motivation to earn a certificate, and score and time spent on the previous problem set (homework). By contrast, student gender, education level, number of previous MOOCs completed, and motivation to participate in online discussion forums did not affect survival.  相似文献   

改革开放40年高等体育教育资源优化配置的社会学审视     

张孔军  钱娅艳 《北京体育大学学报》2019,42(2):103-114

摘要：我国高等体育教育资源优化配置研究引入社会学视角理论与方法，理论与实践均取得专家的认同。运用文献资料法、专家访谈法和实地考察法等方法发现，在计划经济体制下我国高等体育教育资源配置主体单一性、手段行政化和政治倾向性强，凸显出高等体育教育资源配置缺乏激励机制和市场竞争机制的问题，造成高等体育教育资源配置成本最大化和社会效应的最小化问题较多。自改革开放以来,随着我国市场经济体制的建立为高等体育教育资源优化配置提供了难得的发展机遇，我国高等体育教育资源配置取得了明显成效，但仍然存在高等体育教育资源配置机制滞后、体制机制改革创新步伐缓慢、高等体育教育资源配置不合理以及民办普通高校体育教育资源配置严重不足等问题。据此，从社会学研究的视角，提出了构建多主体推动高等体育教育资源优化配置创新的发展模式、多元化高等体育教育资源优化配置资金投入的保障体系、高等体育教育资源优化配置均衡发展的运行机制和大学城体育教育资源“共建共享”的创新发展模式的新时代我国高等体育教育资源优化配置的发展策略，旨在服务新时代全民健身与全民健康深度融合发展，“推动构建人类命运共同体”发展目标的实现。  相似文献