不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制研究     

李洁  杨静  赵丽丽 《武汉体育学院学报》2019,53(5):88-94

目的：探讨不同负荷运动训练对大鼠骨骼肌线粒体三羧酸循环的影响及其机制。方法：将雄性Wistar大鼠50只随机均分为5组：安静对照组（C）、低负荷运动训练组（LT）、中等负荷运动训练组（MT）、高负荷运动训练组（HT）和极高负荷运动训练组（ST），每组10只。各运动组分别进行6周的跑台运动训练。训练方案结束后，取腓肠肌样本，提取线粒体，测定线粒体柠檬酸合成酶（CS）、异柠檬酸脱氢酶（ICD）和α-酮戊二酸脱氢酶（α-KGDHC）活性；线粒体Ga²⁺含量、胞浆NADH、NAD⁺、ATP和ADP含量，以及ICD mRNA转录水平。结果：（1）不同负荷运动训练组线粒体CS、ICD和α-KGDHC的活性均显著高于安静对照组（P < 0.01），且CS和ICD活性由高到低顺序均为：MT组 > HT组 > ST组 > LT组 > C组，α-KGDHC活性由高到低顺序为：HT组 > MT组 > ST组 > LT组 > C组。（2）不同负荷运动训练组线粒体Ca²⁺ 含量均显著高于安静对照组（P < 0.01），其含量由高到低顺序为：MT组 > HT组 > ST组 > LT组 > C组；胞浆NADH/NAD⁺和ATP/ADP的比值均显著低于安静对照组（P < 0.01），其比值由低到高顺序为：MT组 < ST组 < HT组 < LT组 < C组。（3）不同负荷运动训练组ICD mRNA转录水平均高于安静对照组（P < 0.01），其水平由高到低顺序为： MT组 > HT组 > ST组 > LT组 > C组。结论：低负荷、中等负荷、高负荷及极高负荷运动训练均可提高大鼠骨骼肌线粒体三羧酸循环功能，且中等负荷运动训练效果最佳。其机制与胞浆NADH/NAD⁺和ATP/ADP比值、线粒体摄钙能力及限速酶基因的表达有关。  相似文献   

“三个转型”综合改革：新时代世界一流体育大学发展的历史选择     

曹卫东 《北京体育大学学报》2019,42(1):17-22

摘要：新时代是我国发展新的历史方位，体育强国、教育强国、健康中国三大战略为世界一流体育大学提出了新的更高要求。为此，北京体育大学提出了“三个转型”综合改革，以推进世界一流体育大学建设和高水平竞技体育后备人才培养基地建设，为国家培养勇担新时代体育事业发展重任的优秀人才。为实现上述目标，应在深刻认识“三个转型”改革提出的背景基础上，深入理解“三个转型”的内涵与目标，全面推进“三个转型”综合改革，为新时代体育、教育事业贡献北京体育大学的力量。研究背景包括：1）新时代是“三个转型”的历史坐标，2）强国战略是“三个转型”的现实依据，3）创新模式是“三个转型”的客观需要；“三个转型”分别是：1）全面推进从传统经验型体育大学向现代科技型体育大学转型，2）从以夏季项目为主的体育大学向夏季冬季项目全面发展的体育大学转型，3）从本土化体育大学向国际化体育大学转型，其目的是实现两大办学目标：1）把北京体育大学建成中国高水平竞技体育后备人才培养基地，2）把北京体育大学建设成为世界一流体育大学；为了实现“三个转型”转型及其目标，必须准确把握“办大学与建基地、文化传承与科技创新、立足中国与放眼世界”三个维度及其核心关键问题。  相似文献   

Combined effects of exposure to hypoxia and cool on walking economy and muscle oxygenation profiles at tibialis anterior     

Masahiro Horiuchi  Yoko Handa-Kirihara  Daijiro Abe  Yoshiyuki Fukuoka 《Journal of sports sciences》2019,37(14):1638-1647

We investigated combined effects of ambient temperature (23°C or 13°C) and fraction of inspired oxygen (21%O₂ or 13%O₂) on energy cost of walking (C_w: J·kg^?1·km^?1) and economical speed (ES). Eighteen healthy young adults (11 males, seven females) walked at seven speeds from 0.67 to 1.67 m s^?1 (four min per stage). Environmental conditions were set; thermoneutral (N: 23°C) with normoxia (N: 21%O₂) = NN; 23°C (N) with hypoxia (H: 13%O₂) = NH; cool (C: 13°C) with 21%O₂ (N) = CN, and 13°C (C) with 13%O₂ (H) = CH. Muscle deoxygenation (HHb) and tissue O₂ saturation (StO₂) were measured at tibialis anterior. We found a significantly slower ES in NH (1.289 ± 0.091 m s^?1) and CH (1.275 ± 0.099 m s^?1) than in NN (1.334 ± 0.112 m s^?1) and CN (1.332 ± 0.104 m s^?1). Changes in HHb and StO₂ were related to the ES. These results suggested that the combined effects (exposure to hypoxia and cool) is nearly equal to exposure to hypoxia and cool individually. Specifically, acute moderate hypoxia slowed the ES by approx. 4%, but acute cool environment did not affect the ES. Further, HHb and StO₂ may partly account for an individual ES.  相似文献   

Differences in determinants of aerobic and muscle strengthening physical activity among college students: a reasoned action approach     

Paul Branscum  Grace Fairchild 《Journal of sports sciences》2019,37(1):90-99

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聚力探索特色小镇 开辟体产全新格局——北京大学第9届中国体育产业高峰论坛综述     

赵雯婷  丁怡清  封英  张锐 《北京体育大学学报》2019,42(2):95-102

摘要：习近平总书记在十九大报告中出要广泛开展全民健身活动，加快推进体育强国建设。随着“健康中国”上升为国家战略、居民消费升级需求日益加深，我国运动休闲特色小镇的发展路径显得尤为重要。在此背景下，专家学者和业界名流齐聚北京大学，集思广益、畅所欲言，为特色小镇献计献策，共商特色小镇建设合作大计。此次中国体育产业高峰论坛分论坛以“运动休闲特色小镇”为主题，对运动休闲特色小镇这个概念进行了全方位、系统性的深刻剖析，并结合运动休闲特色小镇相关成功实践经验，从前期策划、设计、投资到后期的建设、运营，再到内容为王、跨界融合、聚集建构效应，多层次、多角度阐释了运动休闲特色小镇建构的内在机理和方法，为建设运动休闲特色小镇事业，开创全新体育文化产业格局提供了切实可行的路径。  相似文献   

Understanding the topic evolution of scientific literatures like an evolving city: Using Google Word2Vec model and spatial autocorrelation analysis     

Kai Hu  Qing Luo  Kunlun Qi  Siluo Yang  Jin Mao  Xiaokang Fu  Jie Zheng  Huayi Wu  Ya Guo  Qibing Zhu 《Information processing & management》2019,56(4):1185-1203

Topic evolution has been described by many approaches from a macro level to a detail level, by extracting topic dynamics from text in literature and other media types. However, why the evolution happens is less studied. In this paper, we focus on whether and how the keyword semantics can invoke or affect the topic evolution. We assume that the semantic relatedness among the keywords can affect topic popularity during literature surveying and citing process, thus invoking evolution. However, the assumption is needed to be confirmed in an approach that fully considers the semantic interactions among topics. Traditional topic evolution analyses in scientometric domains cannot provide such support because of using limited semantic meanings. To address this problem, we apply the Google Word2Vec, a deep learning language model, to enhance the keywords with more complete semantic information. We further develop the semantic space as an urban geographic space. We analyze the topic evolution geographically using the measures of spatial autocorrelation, as if keywords are the changing lands in an evolving city. The keyword citations (keyword citation counts one when the paper containing this keyword obtains a citation) are used as an indicator of keyword popularity. Using the bibliographical datasets of the geographical natural hazard field, experimental results demonstrate that in some local areas, the popularity of keywords is affecting that of the surrounding keywords. However, there are no significant impacts on the evolution of all keywords. The spatial autocorrelation analysis identifies the interaction patterns (including High-High leading, High-Low suppressing) among the keywords in local areas. This approach can be regarded as an analyzing framework borrowed from geospatial modeling. Moreover, the prediction results in local areas are demonstrated to be more accurate if considering the spatial autocorrelations.  相似文献   

A multi-nation examination of the fatigue and recovery time course during the inaugural Under-18 Six Nations rugby union competition     

Carlos Ramírez-López  Kevin Till  Thomas Sawczuk  Pierosario Giuliano  Alexis Peeters  Grant Beasley 《Journal of sports sciences》2020,38(6):644-651

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Reference power values for the jump squat exercise in elite athletes: A multicenter study     

Pedro L. Valenzuela  Michael McGuigan  Guillermo Sánchez-Martínez  Elaia Torrontegi  Javier Vázquez-Carrión  Zigor Montalvo 《Journal of sports sciences》2020,38(19):2273-2278

ABSTRACT

The present study aimed to provide reference values for lower-limb muscle power assessed during the incremental jump squat (JS) test in elite athletes (i.e., professional athletes competing at international level). We pooled data from all JS tests performed by elite athletes of different sports in two high-performance centres between 2015 and 2019, and computed reference values (i.e., terciles) for mean power (MP), mean propulsive power (MPP), and peak power (PP). Reference values were obtained from 684 elite athletes (458 male and 226 female) of 16 different sports (boxing, judo, karate, fencing, taekwondo, wrestling, basketball, soccer, futsal, handball, rugby union, badminton, tennis, long distance running, triathlon, and sprinting). Significant differences (p < 0.001) were found between male and female athletes for MP (7.47 ± 1.93 and 6.15 ± 1.68 W·Kg^?1, respectively), MPP (10.50 ± 2.75 and 8.63 ± 2.43 W·Kg^?1), and PP (23.64 ± 6.12 and 19.35 ± 5.49 W·Kg^?1). However, the velocity at which these power measures was attained seemed to be independent of sex (~0.95, 1.00 and 2.00 m·s^?1 for mean, mean propulsive, and peak velocity, respectively) and homogeneous across different sport disciplines (coefficient of variation <10%). These data can be used to classify athletes’ power capabilities, and the optimum velocity ranges provided here could be useful for training purposes.  相似文献   

运动因子在心血管功能中的调控作用及相关机制研究进展     

于凤至  孙朋  刘淑卉 《中国体育科技》2020,(5):48-58

心血管疾病(cardiovascular disease,CVD)是包括动脉粥样硬化、心力衰竭、心脏缺血后再灌注损伤和心肌梗死等血管和心脏的复杂病症。血管内皮细胞、平滑肌细胞和心肌细胞生理功能障碍是诱发CVD的关键因素。研究表明,运动能够对心脏和动脉的形态、功能起到积极的调控作用,可作为CVD非药物疗法的重要手段之一。运动可通过调控多种运动因子的表达水平,如肌肉分泌的Fstl1、Irisin和MSTN,脂肪分泌的Omentin、Apelin、CTRP3和CTRP9,肝脏分泌的FGF21、ANGPTL3和ANGPTL4等,进而调控血管内皮细胞、平滑肌细胞和心肌细胞的分化、增殖和凋亡,从而发挥其防治CVD作用。本文试图梳理肌肉、脂肪和肝脏分泌的运动因子与调控心脏和动脉功能之间的相关信号通路及其机制,为运动干预防治CVD提供新的思路。  相似文献   

改革开放40年高等体育教育资源优化配置的社会学审视     

张孔军  钱娅艳 《北京体育大学学报》2019,42(2):103-114

摘要：我国高等体育教育资源优化配置研究引入社会学视角理论与方法，理论与实践均取得专家的认同。运用文献资料法、专家访谈法和实地考察法等方法发现，在计划经济体制下我国高等体育教育资源配置主体单一性、手段行政化和政治倾向性强，凸显出高等体育教育资源配置缺乏激励机制和市场竞争机制的问题，造成高等体育教育资源配置成本最大化和社会效应的最小化问题较多。自改革开放以来,随着我国市场经济体制的建立为高等体育教育资源优化配置提供了难得的发展机遇，我国高等体育教育资源配置取得了明显成效，但仍然存在高等体育教育资源配置机制滞后、体制机制改革创新步伐缓慢、高等体育教育资源配置不合理以及民办普通高校体育教育资源配置严重不足等问题。据此，从社会学研究的视角，提出了构建多主体推动高等体育教育资源优化配置创新的发展模式、多元化高等体育教育资源优化配置资金投入的保障体系、高等体育教育资源优化配置均衡发展的运行机制和大学城体育教育资源“共建共享”的创新发展模式的新时代我国高等体育教育资源优化配置的发展策略，旨在服务新时代全民健身与全民健康深度融合发展，“推动构建人类命运共同体”发展目标的实现。  相似文献