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目的：针对世居高平原45～55岁的人群,观察高原低氧环境健身运动对其血脂HDL-C、LDL-C的影响,以期为促进高平原人群健康提供参考依据。方法：研究对象分为高原实验组（高原组、平原组）和对照组三组。实验方法分为高原和平原实验两部分,实验期共7周,其中适应期1周,实验期3周,观察期3周。实验组在青海多巴（2366m,2周）、天峻（3480~3700m,1周）集中进行高原训练,每周采集1次指标。对照组在陕西户县余下镇（395m）采取集中训练、非集中住宿的方式进行健身锻炼,在实验初期、末期和观察末期采集指标3次。结果：男子高原组、平原组的HDL-C均呈下降趋势,且高原组下降非常显著（P<0.01）,对照组则呈显著上升（P<0.05）。女子平原组HDL-C呈下降趋势,高原组、对照组均有所增长。男子高原组、平原组LDL-C呈上升趋势,对照组呈下降趋势。女子高原组LDL-C上升水平非常显著（P<0.01）,平原组LDL-C呈上升趋势,对照组则下降显著（P<0.05）。男子高原组LDL-C/HDL-C值在标准范围内表现出上升趋势,平原组上升显著（P<0.05）,对照组在观察末期显著下降（P<0.05）。女子高原组LDL-C/HDL-C值在标准范围内呈现上升趋势,平原组上升显著（P<0.05）,而对照组在标准范围内显著下降（P<0.05）。结论：在高原进行健身锻炼时应注意控制饮食以及掌握好高原健身运动的负荷量和强度,同时,应适当考虑延长在高原居留时间。 相似文献
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Suchanda Sahu MBBS MD Rajinder Chawla Bharti Uppal 《Indian journal of clinical biochemistry : IJCB》2005,20(2):54-61
Current recommendations of the Adult Treatment Panel and Adolescents Treatment Panel of National Cholesterol Education Program
make the low-density lipoprotein cholesterol (LDL-C) levels in serum the basis of classification and management of hypercholesterolemia.
A number of direct homogenous assays based on surfactant/solubility principles have evolved in the recent past. This has made
LDL-C estimation less cumbersome than the earlier used methods. Here we compared one of the direct homogenous assays with
the widely used Friedewald’s method of estimation of LDL-C to see the differences and correlation. We used direct homogenous
assay kit to estimate serum LDL-C and high-density lipoprotein cholesterol (HDL-C). Serum Triglyceride (TG) and Total Cholesterol
(TC) was estimated and using Friedewald’s formula LDL-C was calculated. The LDL-C level obtained by both methods in 893 fasting
serum samples were compared. The statistical methods used were paired t-test and Pearson’s correlation.
There was significant difference in the mean LDL-C levels obtained by the two methods at the TG levels <200 mg/dl (p<0.02)
and TC levels >150 mg% (p<0.001). The correlation coefficient (r) between Friedewald’s and direct assay estimation was 0.88.
Friedewald’s method classified 23.5 % of patients as high cardiac risk whereas there were 17.58% by direct assay.
Both had good correlation even though the serum triglyceride and total cholesterol levels affect the difference in LDL-C estimated
by both methods. Taking into account the cost and performance, Friedewald’s method is as good or even better for classifying
and managing patients. 相似文献
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Shalini Gupta Minni Verma Kamaljit Singh 《Indian journal of clinical biochemistry : IJCB》2012,27(2):127-133
Estimation of low density lipoprotein cholesterol (LDL-C) is crucial in management of coronary artery disease patients. Though a number of homogenous assays are available for estimation of LDL-C, use of calculated LDL-C by Friedewald’s formula (FF) is common in Indian laboratories for logistic reasons. Recently Anandaraja and colleagues have derived a new formula for calculating LDL-C. This formula needs to be evaluated before it is extensively applied in diagnosis. We measured LDL-C by homogenous method (D-LDL-C) in 515 fasting samples. Friedewald’s and Anandaraja’s formulas were used for calculation of LDL-C (F-LDL-C and A-LDL-C, respectively). The mean LDL-C levels were 123.3 ± 53.2, 112.4 ± 50.2 and 109.2 ± 49.8 mg/dl for D-LDL-C, F-LDL-C and A-LDL-C, respectively. There was a statistically significant difference between the results (P > 0.001) obtained by calculation formulas compared to the measured LDL-C. There was underestimation of LDL-C by 10.8 and 14 mg/dl by Friedewald’s and Anandaraja’s formulas respectively. The Pearson’s correlation between F-LDL-C and D-LDL-C was 0.931 and that between A-LDL-C and D-LDL-C was 0.930. Bland–Altman graphs showed a definite agreement between mean and differences of the calculation formulas and direct LDL-C with 95% of values lying with in ±2 SD limits. The mean percentage difference (calculated as {(Calculated LDL-C)-(D-LDL-C)}/D-LDL-C × 100) for F-LDL-C was maximum (−11.6%) at HDL-C ≥ 60 mg/dl and TG levels of 200–300 mg/dl (−10.4%) compared to D-LDL-C. A-LDL-C results gave highest mean percentage difference at total cholesterol concentrations <100 mg/dl (−37.3%) and HDL-C < 40 mg/dl (−17.1%), respectively. The results of our study showed that FF is better in agreement with D-LDL-C than Anandaraja’s formula for estimation of LDL-C by calculation though both lead to its underestimation. 相似文献
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摘要：目的：观察12周抗阻训练对ACE基因D/I多态性绝经女性血管内皮功能的影响。方法：选取55-75岁绝经女性63名，受试者无其他疾病史，无服用降血压药物及降血脂药物史。采集口腔黏膜细胞检测ACE基因D/I分型，进行12周抗阻训练。干预前后检测受试者血脂四项（TC、LDL-C、HDL-C和TG）和血管内皮功能（FMD）。结果：1）所选绝经女性I型基因比例61.11%，D型基因比例38.39%，符合Hardy-weinberg遗传平衡定律，具有群体代表性；2）ACE基因DD型绝经女性血脂异常率明显高于II/DI型（X2=162，P=0.000），且以LDL-C和TC增高为主；3.DD型绝经女性FMD值明显低于II/DI型（P＜0.01），FMD异常率明显高于II/DI型（X2=135，P=0.000）；4.12周抗阻训练ACE基因各表型绝经女性血脂异常率和FMD异常率均有所下降，以DD型最为明显（P＜0.01 or P＜0.05），血脂系列以LDL-C下降最明显（P＜0.01）。结论：ACE基因DD型具有较高的脂代谢及血管内皮功能异常发生率；12周抗阻训练，所有受试者脂代谢及血管内皮功能均有所改善，但不同ACE基因D/I表型指标变化存在一定差异，DD型个体对于抗阻训练更为敏感。本结果是个性化健身方案制定的依据之一。 相似文献
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李军 《西安体育学院学报》2007,24(1):85-88,117
目的观察长时间空竹锻炼对老年人血脂变化的影响。方法采用趣味性、技巧性的空竹锻炼,对河南师范大学退休老年人进行空竹锻炼试验,并与对照组的血脂进行对比检查。结果空竹锻炼可以提高老年人高密度脂蛋白胆固醇(HDL-C)浓度,男子提高0.19 mmol/L;降低胆固醇(TC)、低密度脂蛋白和甘油三脂的浓度,男和女分别降低0.54、0.78、0.66(mmol/L)和0.77、0.79、0.75(mmol/L);TC/HDL-C比值分别下降0.99和0.65。在空竹锻炼的过程中,提高了老年人的心理健康水平。结论长时间的空竹锻炼可以有效的改善老年人血脂水平,提高老年人心血管机能,延缓衰老,并对老年人的心理健康起到积极的作用。 相似文献
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