基于负样本多通道优化SSD网络的钢铁厂提取     

卢凯旋  李国清  陈正超  昝露洋  李柏鹏  高建威 《中国科学院大学学报》2020,37(3):352-359

准确提取钢铁厂对去产能监测和环境保护具有重要意义。传统的人工目视解译方法效率低、成本高，无法满足开展大区域钢铁厂监测的需求。以深度学习目标检测网络SSD为基础，构建面向遥感影像钢铁厂提取的深度学习目标检测网络，提出maxout模块，将负样本通路优化为多分支结构，突出难分负样本特征并提升网络对无用特征的抵制效果。利用国产GF-1数据对京津冀地区的钢铁厂进行快速自动提取实验。与人工解译的钢铁厂点位数据的对比表明，该目标检测方法的提取精度达到80%以上。  相似文献   

低负荷加压训练改善自发性高血压大鼠的血压效果及机制研究     

谭朝文  赵彦  俞莹莹  马晓缓  郑玉婵 《体育科学》2020,(3):46-53,63

目的:探究低负荷加压训练对自发性高血压大鼠的降压效果及其作用机制。方法:选取4周龄雄性自发性高血压大鼠,随机分为对照组(高血压安静组)、低负荷训练组、低负荷加压训练组和高负荷训练组。低负荷训练组进行35%~55%1RM递进式低负荷爬梯训练,低负荷加压训练组进行30%~40%血流受限结合35%~55%1RM递进式低负荷爬梯训练,高负荷训练组进行55%~75%1RM递进式高负荷爬梯训练,训练后测定血压、血液中内皮素-1、血管内皮生长因子、一氧化氮合成酶的表达和心肌组织中内皮型一氧化氮合成酶的表达。结果:1)与对照组、高负荷训练组相比,低负荷加压训练组收缩压、舒张压显著下降(P<0.05);与低负荷训练组相比,低负荷加压训练组舒张压显著下降(P<0.05)。2)与对照组相比,低负荷加压训练组血液中内皮素-1表达显著下调(P<0.05),血管内皮生长因子和一氧化氮合成酶表达显著上调(P<0.05);3)与对照组相比,低负荷加压训练组心肌中内皮型一氧化氮合成酶表达显著上调(P<0.05);4)在低负荷加压训练组中,收缩压与内皮素-1呈正相关,相关性分析具有统计学意义(P<0.05);收缩压与一氧化氮合成酶、血管内皮生长因子、内皮型一氧化氮合成酶均呈负相关,相关性分析具有统计学意义(P<0.05)。结论:1)低负荷加压训练降压效果优于高负荷训练;2)低负荷加压训练能够通过下调血液中内皮素-1的表达,上调血液中血管内皮生长因子和一氧化氮合成酶的表达,同时上调心肌中内皮型一氧化氮合成酶表达,改善内皮细胞功能,达到降压的效果。  相似文献   

Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Bilingual education through a pluri-centric approach: A case study of the effects of simultaneously learning two languages on L1 and L2 reading and writing proficiency     

《Studies in Educational Evaluation》2020

Language education has often been conducted based on monoglossic ideologies that keep L1 and L2 separate, a practice that receives growing criticism as out of sync with today’s multilingual globalized world. Informed by interdependence hypotheses and translanguaging theory, this research study explored the effects of a pluri-centric approach to learning L1 and L2 simultaneously. Through a bilingual intervention course with data collected from interviews, parents’ logbooks, observation field notes, questionnaires, and L1 and L2 reading and writing tests, this case study (n = 9) revealed that the approach effectively improved learners’ L1 and L2 proficiency, learning behaviour outside the classroom, self-efficacy, and confidence. Overall, the participants also perceived the bilingual course as effective, efficient, and innovative. The study provides a basis to reflect upon transferrable skills and core underlying proficiency as powerful concepts to draw upon in enhancing bilingual proficiency and effecting positive changes in learners’ behaviour and psychological well-being.  相似文献   

R&D co-operation and innovation a microeconometric study on French firms     

S. Negassi 《Research Policy》2004,33(3):365-384

The scope of this paper is to report new empirical evidence on the determinants of R&D co-operation. Indeed, the literature on the capabilities of firms emphasises the role of knowledge in the performance and evolution of firms who use knowledge developed in others to build their own knowledge capital. R&D co-operation between firms is one of the many strategies by which this knowledge may be transmitted. Several theoretical models have stressed that R&D co-operation is more likely when the level of spillovers is high. While this supposition is used in many theoretical models, it has rarely been tested before. Our results do not lend strong support to this intuition. Indeed, our spillover variables (national pure spillovers, national rent spillovers and imports of machine tools), which were supposed to match the theoretical notion of spillovers used in these theoretical models have a positive but not a significant role when explaining R&D co-operation. The R&D co-operation increases with size and with R&D intensity, but not with market share. It also increases with the budget spent on paying license fees and on acquiring patents and labour from foreign firms. In this study, we also analyse the determinants of innovation. In more precise terms, we compare the effects of R&D co-operation to those played by traditional internal factors and those exerted by external, pure and rent spillovers on the innovation capacity of the firms. Our results show that the commercial success of innovations of French firms depends mainly on size, market share, R&D intensity and human capital. Inward FDI from industrialised countries exerts a positive and significant effect. The finding highlights the important role of the absorptive capacity of firms. Spillover measurements, such as the acquisition of machine tools, foreign patents, licenses, and technological opportunities have a positive impact on innovation.  相似文献   

AQP-1和AQP-5在卵巢上皮性肿瘤的表达及临床意义     

杨建华  石一复  周彩云  王国萍 《科技通报》2006,22(6):781-784,791

目的探讨AQP1及AQP5在卵巢上皮性肿瘤的表达及临床意义。方法采用免疫组化法检测105例卵巢上皮性肿瘤和10例正常卵巢组织AQP1和AQP5蛋白的表达。结果AQP1主要表达于毛细血管及小血管内皮细胞．而AQP5表达于卵巢肿瘤细胞。随着卵巢上皮性肿瘤由良性向恶性发展，AQP1和AQP5的表达逐渐增加（P〈0．05）。Ⅲ、Ⅳ期卵巢癌AQP1的表达明显高于Ⅰ、Ⅱ期（P〈0．05），伴淋巴转移者AQP1明显高于无淋巴转移者（／9〈0．05）；腹水大于1000mL者AQP1和AQP5的表达明显高于小于1000mL者（P〈0．01）：低分化卵巢癌AQP5的表达明显高于高、中分化者（P〈0．05）；AQP1及AQP5的表达与腹水量呈正相关（r分别为0．40，0.31；P〈0．05）。结论AQP1和AQP5高表达与卵巢癌的发生、发展及预后有关，可能是卵巢癌腹水产生的主要原因。  相似文献   

Expression of antimicrobial peptide Cecropin P1 in Saccharomyces cerevisiae and its antibacterial and antiviral activity in vitro     

《Electronic Journal of Biotechnology》2021

BackgroundCecropin P1, acting as an antimicrobial, has a broad-spectrum antibacterial activity with some antiviral and antifungal properties. It is a promising natural alternative to antibiotics which is originally isolated from the pig intestinal parasitic nematode Ascaris suum. Many studies have shown that Cecropin P1 is helpful for the prevention or treatment of clinical diseases. Therefore, it is very necessary to establish a safe, nontoxic, and efficient expression method of Cecropin P1.ResultsThe results indicated that the recombinant protein was about 5.5 kDa showed by Tricine–SDS–PAGE and Western blot. And Cecropin P1 was efficiently secreted and expressed after 12 h of induction, with an increasing yield over the course of the induction. Its maximum concentration was 7.83 mg/L after concentration and purification. In addition, in vitro experiments demonstrated that Cecropin P1 not only exerted a strong inhibitory effect on Escherichia coli, Salmonella sp., Shigella sp., and Pasteurella sp., but also displayed an antiviral activity against PRRSV NADC30-Like strain.ConclusionsCollectively, the strategy of expressing Cecropin P1 in Saccharomyces cerevisiae is harmless, efficient, and safe for cells. In addition, the expressed Cecropin P1 has antiviral and antibacterial properties concurrently.How to cite: Jiang R, Zhang P, Wu X, et al., Expression of antimicrobial peptide Cecropin P1 in Saccharomyces cerevisiae and its antibacterial and antiviral activity in vitro. Electron J Biotechnol 2021;50. https://doi.org/10.1016/j.ejbt.2020.12.006  相似文献   

Effects of short-term hormone replacement on atherogenic indices in Indian postmenopausal women     

Sarika Arora  Anju Jain  R Chitra 《Indian journal of clinical biochemistry : IJCB》2006,21(1):41-47

Indian ethnicity by itself is a strong risk factor for development of CAD in Indian postmenopausal women due to lower HDL levels as compared to Whites and women of oriental origin. We evaluated and compared the short-term effects of menopause, estrogen replacement therapy and combined estrogen and progestin replacement therapy on various atherogenic indices. 40 postmenopausal women, both surgical and natural (20 each) were selected. 10 surgical postmenopausal women were given 0.625 mg conjugated estrogens daily for 6 months and 10 natural postmenopausal women were given 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone acetate daily. 20 women were included in the control group and given placebo. Fasting venous blood samples were analyzed for extended lipid profile and calculated atherogenic indices before starting the therapy and after 1,3 and 6 months. LDL and Apolipoprotein B increased (p<0.05) and those of Apolipoprotein A1 and HDL decreased in the control groups. In both the study groups levels of serum cholesterol and LDL decreased (p<0.05) and those of HDL and Apolipoprotein A1 increased (p<0.01). LDL/HDL, Apo B/ApoA1, Total Cholesterol/HDL decreased significantly (p<0.05) in both the study groups compared to the control groups. The effect of estrogen alone was more significant as compared to combination therapy. Log Triglycerides (TG)/HDL ratio showed a decrease in women on estrogen alone but the difference was not significant. Our study confirms that short term HRT has a favorable effect on atherogenic indices in Indian postmenopausal women.  相似文献   

变异系数加权的组合赋权模型及科技评价实证          下载免费PDF全文

石宝峰  程砚秋  王静 《科研管理》2016,37(5):122-131

通过R聚类剔除反映信息重复的指标,利用因子分析遴选对科技评价影响较大的指标,构建了能够反映科学发展观内涵的科技评价指标体系。在此基础上,利用变异系数对主观G1权重、客观余弦夹角权重进行组合加权,建立了基于变异系数加权的组合赋权模型,并对中国14个典型的省份科技评价数据进行了实证。创新与特色:一是通过变异系数对主观G1权重、客观余弦夹角权重进行加权,构建了变异系数加权后组合权重最大的目标函数,进而确定了主、客观权重的组合系数θ_1、θ_2,反映了组合赋权中主、客观权重分布变异性越大、权重越大的赋权思路。弥补了现有组合赋权中主、客观权系数相等,无法有效反映专家知识经验和客观数据差异的不足。二是实证研究表明:科技投入不足是制约江西、广西两省科技发展较差的主要因素;科技对经济与社会的影响偏弱是制约四川省科技发展的关键因素;科技产出不足是制约黑龙江、山东、河南三省科技发展的瓶颈因素。  相似文献   

线粒体nad1基因内含子在稻族系统学研究中的价值——兼论Porteresia的系统位置     

郭亚龙  葛颂 《中国科学院研究生院学报》2004,42(4):333-344

在植物的系统与进化研究中，相对于叶绿体和核基因片段来说，线粒体基因片段由于其分辨率较低、结构复杂而较少应用到系统学研究中。本研究选用nad1基因的第2内含子序列探讨了稻族Oryzeae的系统发育关系，并着重分析了单型属Porteresia的系统学位置，并在此基础上探讨了nad1基因内含子序列的系统学意义以及空位性状在系统发育重建中的价值。本研究结果支持将稻族分为两个亚族（Oryzinae和Zizaniinae）的处理，稻族中假稻属Leersia与稻属Oryza最近缘，Porteresia coarctata不应该单独成属而应处理为稻属的成员。本研究表明，nad1第2内含子具有一定的系统发育信息，尤其是在较高分类等级的系统发育重建中具有较大价值；同时表明空位的合理利用将在已有序列信息基础上提供更多的系统发育信息。  相似文献