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1.
Cynthia Jane A. V. Nerurkar F. R. Karjodkar 《Indian journal of clinical biochemistry : IJCB》2007,22(2):114-117
Oral Cancer is one of the five leading sites of cancer in Indian population. The circulating immune complexes were investigated
in 100 serum samples of 60 oral cancer patients having different grades of the disease and 40 patients with precancerous lesions
obtained from Nair Hospital Dental collage, Mumbai. The results obtained were compared with those of group of 40 healthy blood
donors. Elevated levels of Circulating Immune Complexes were observed in oral cancer patients and patients with oral precancerous
lesions. 92% positive samples were observed in well differentiated squamous cell carcinoma whereas 100% positive samples were
observed in both moderately and poorly differentiated squamous cell carcinoma. Oral leukoplakia and oral submucous fibrosis
showed 15% and 90% positivity respectively. Increased level of Circulating Immune complexes in high grade tumor suggest that
Circulating Immune complexes is likely to contribute in evaluating the degree of malignancy, but follow up study is needed
to draw any conclusion regarding it's prognostic role 相似文献
2.
V. A. Doss Dharaniyambigai Kuberapandian 《Indian journal of clinical biochemistry : IJCB》2021,36(1):33
The main objective of this study is to evaluate the anti-hypertrophic potential of the aqueous extract of Enicostemma littorale (E. littorale) against isoproterenol induced cardiac hypertrophic rat models (male albino Wistar rats) through biochemical investigations. Aqueous extract of E. littorale known for various beneficial properties was administered (100 mg/kg, 12 days, oral) to isoproterenol (ISO) induced cardiac hypertrophic rats (low ISO—60 mg/kg, 12 days and high ISO—100 mg/kg, 12 days, subcutaneous) and were compared with group that was treated with the reference drug, Losartan (10 mg kg, administered for 12 days, oral). The anti-hypertrophic effect of E. littorale was evaluated by analysing the morphometric indices of the heart, ECG tracings, changes in blood biochemical parameters viz., serum glucose, serum total protein, serum albumin, lipid profile, cardiac specific enzymes (SGOT, SGPT and LDH) and histopathological examination of the heart tissue. The results fundamentally revealed that the plant extract efficiently ameliorated cardiac hypertrophy induced by ISO injected in experimental rats. The outcomes of biochemical investigations of this study highlighted the association between the hypertrophic β-adrenergic receptor signalling (β-AR) and the 5′ AMP-activated protein kinase (AMPK)—peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) axis in the metabolism of cardiac fibrosis and hypertrophy. This β-AR/AMPK-PGC1α signalling stem can serve as a key target in ameliorating cardiac hypertrophy through focus on its principal regulators. To add, we also propose that the glycoside, swertiamarin present in this plant with the reported anti-fibrotic potential in liver can be further isolated and evaluated for its anti-hypertrophic potential to treat cardiac hypertrophy. 相似文献
3.
Evelyn Cecile Bowtell Rosalie Aroni Julie Green Susan M. Sawyer 《International Journal of Inclusive Education》2018,22(2):176-191
Schools in Australia are required to promote equitable access to education and provide support services to students with chronic health conditions (CHCs). This qualitative study was conducted to explore stakeholders’ experiences and perceptions regarding school-based support. In-depth interviews were conducted with 38 parents of upper secondary school students with cystic fibrosis, anorexia nervosa or cancer (which were illustrative of different types of severe congenital, mental health or somatic CHCs). This enabled comparison of findings to determine whether there were any patterns in perceptions and experiences that were tied to the different CHCs. Data were analysed using a modified grounded theory approach to identify themes. Even though analysis indicated that all cohorts of parents viewed informed educators as best placed to provide tailored school-based support, major cohort differences were reported in parental experiences of school-based support as well as parental diagnosis disclosure behaviour. This latter finding was associated with cohort-related perceptions of risk to their adolescent child. Barriers to school-based support were perceived as varying by condition, the advocacy experience of parents and the nature of health service supports. Taking these findings into account, modification of current policies and practices within education and health sectors may lead to more equitable educational outcomes. 相似文献
4.
针刺对骨骼肌拉伤恢复进程中纤维化因子的影响 总被引：1，自引：0，他引：1
摘要：目的：探讨针刺对骨骼肌拉伤后纤维化进程的抑制效应及可能机制。方法：224只雄性SD大鼠随机分为对照组、拉伤组、针刺组和拉伤后针刺组。每组又分为即刻、2、4、7、14、21和28 d组,每组8只。对照组无干预;拉伤组用大鼠腓肠肌拉断仪建模;拉伤后针刺组在拉伤后每隔天针刺一次;针刺组与拉伤后针刺组同步。干预末次取腓肠肌备用。采用Masson染色法观察肌纤维损伤及炎症、western blot检测TGF-β1、CTGF、MMP-1、TIMP-1蛋白的表达情况。结果：与对照组相比,拉伤组骨骼肌肌TGF-β1,CTGF,MMP-1,TIMP-1不同时相起均出现显著增加（P<0.05,P<0.01）;与拉伤组相比,拉伤后针刺组骨骼肌TGF-β1,CTGF,TIMP-1不同时相起均出现显著减少（P<0.05）,MMP-1无显著变化（P>0.05）。拉伤组MMP-1/TIMP-1蛋白比值仅在2d、4 d明显高于对照组（P<0.05）,之后迅速恢复（P>0.05）;拉伤后针刺组MMP-1/TIMP-1蛋白比值7 d起持续明显高于拉伤组（P<0.01）。结论：针刺可能通过下调TGF-β1/CTGF通路、上调MMP-1/TIMP-1蛋白比值抑制骨骼肌损伤修复中纤维化的发生发展。 相似文献
5.
Cheng-jun Yan Su-mei Li Qiang Xiao Yan Liu Jian Hou Ai-fang Chen Li-ping Xia Xiu-chang Li 《Journal of Zhejiang University. Science. B》2013,14(8):721-728
Adiponectin plays an important role in the development of hypertension, atherosclerosis, and cardiomyocyte hypertrophy, but very little was known about the influence of serum adiponectin or the adiponectin gene polymorphism on myocardial fibrosis. Our study investigates the influence of the SNP +45 polymorphism of the adiponectin gene and serum levels of adiponectin on myocardial fibrosis in patients with essential hypertension. A case-control study was conducted on 165 hypertensive patients and 126 normotensive healthy controls. The genotypes of adiponectin gene polymorphisms were detected by the polymerase chain reaction (PCR) method. Serum concentrations of procollagen were measured by a double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in all subjects. The integrated backscatter score (IBS) was measured in the left ventricular myocardium using echocardiography. The serum levels of adiponectin in hypertensive patients were significantly lower than those in the normal control group ((2.69±1.0) μg/ml vs. (4.21±2.89) μg/ml, respectively, P<0.001). The serum levels of type-I procollagen carboxyl end peptide (PICP) and type-III procollagen ammonia cardinal extremity peptide (PIIINP) in the hypertension group were significantly higher than those in the control group. In the hypertension group, serum levels of adiponectin were significantly and negatively related to the average acoustic intensity and corrected acoustic intensity of the myocardium (r=0.46 and 0.61, respectively, P<0.05 for both). The serum levels of PICP and PIIINP were significantly different among the three genotypes of SNP +45 (P<0.01). Logistic regression analyses showed that sex and genotype (GG+GT) were the major risk factors of myocardial fibrosis in hypertensive patients (OR=5.343 and 3.278, respectively, P<0.05). These data suggest that lower levels of adiponectin and SNP +45 polymorphism of the adiponectin gene are likely to play an important role in myocardial fibrosis in hypertensive patients. 相似文献
6.
Cystic fibrosis is a common autosomal recessive disorder usually found in population of white Caucasian descent. Now it is
well documented the presence of CF disease in India with the advancement of laboratory testing. As once it was thought non
existence of this disease in our population. Most of the phenotype of CF disease was in accordance of western population.
Genetic analysis of CFTR gene in Indian CF patients revealed that most common mutation was delta F508 mutation. However, it
was less than Caucasian population. CFTR mutations are also a causative factor in the pathogenesis of male infertility due
to obstructive azoospermia. There are two most common mutation viz. IVS8-T5 and delta F508 which are responsible for congenital
absence of vas deferens in male infertility patients. Elevated levels of sweat chloride at two occasions along with the presence
of two mutations in CFTR gene was gold standard method for diagnosis of CF disease. It is noteworthy here that due to magnitude
of Indian population, the total CF disease load would be more than many European countries. Clinical data demonstrate the
prevalence of both classical and genetic form of CF in India. 相似文献
7.
8.
Chuan ZUO Xi-sheng XIE Hong-yu QIU Yao DENG Da ZHU Jun-ming FAN 《Journal of Zhejiang University. Science. B》2009,10(5)
Astragalus mongholicus (AM) derived from the dry root of Astragalus membranaceus Bge. var. mongolicus (Bge.) Hsiao is a widely used traditional Chinese medicine. The present study investigated the potential role of AM on renal fibrosis on a rat model of unilateral ureteral obstruction (UUO). We divided 48 Sprague-Dawley rats randomly into 4 groups: sham-operated group (Sham), untreated UUO group, AM-treated (10 g/(kg.d)) UUO group, and losartan-treated (20 mg/(kg.d)) UUO group as positive control. Haematoxylin & eosin (HE) and Masson staining were used to study the dynamic histological changes of the kidneys 7 and 14 d after operation. The expressions of fibronectin (FN), type I collagen (coII), hepatocyte growth factor (HGF), transforming growth factor-pi (TGF-βl), and a-smooth muscle actin (a-SMA) were analyzed by real-time polymerase chain reaction (PCR), immunohistochemistry staining, and Western blot. Results show that, similar to losartan, AM alleviated the renal damage and decreased the deposition of FN and colI from UUO by reducing the expressions of TGF-pi and a-SMA (P<0.05), whereas HGF increased greatly with AM treatment (P<0.05). Our findings reveal that AM could retard the progression of renal fibrosis. The renoprotective effect of AM might be related to inhibition of myofibroblast activation, inducing of HGF and reducing of TGF-β1 expression. 相似文献
9.
Chuan Zuo Xi-sheng Xie Hong-yu Qiu Yao Deng Da Zhu Jun-ming Fan 《Journal of Zhejiang University. Science. B》2009,10(5):380-390
Astragalus mongholicus (AM) derived from the dry root of Astragalus membranaceus Bge. var. mongolicus (Bge.) Hsiao is a widely used traditional Chinese medicine. The present study investigated the potential
role of AM on renal fibrosis on a rat model of unilateral ureteral obstruction (UUO). We divided 48 Sprague-Dawley rats randomly
into 4 groups: sham-operated group (Sham), untreated UUO group, AM-treated (10 g/(kg·d)) UUO group, and losartan-treated (20
mg/(kg·d)) UUO group as positive control. Haematoxylin & eosin (HE) and Masson staining were used to study the dynamic histological
changes of the kidneys 7 and 14 d after operation. The expressions of fibronectin (FN), type I collagen (colI), hepatocyte
growth factor (HGF), transforming growth factor-β1 (TGF-β1), and α-smooth muscle actin (α-SMA) were analyzed by real-time
polymerase chain reaction (PCR), immunohistochemistry staining, and Western blot. Results show that, similar to losartan,
AM alleviated the renal damage and decreased the deposition of FN and colI from UUO by reducing the expressions of TGF-β1
and α-SMA (P<0.05), whereas HGF increased greatly with AM treatment (P<0.05). Our findings reveal that AM could retard the progression of renal fibrosis. The renoprotective effect of AM might
be related to inhibition of myofibroblast activation, inducing of HGF and reducing of TGF-β1 expression.
Project (No. 30170437) supported by the National Natural Science Foundation of China 相似文献
10.
曹〓姣 《广州体育学院学报》2018,(5):106-112
目的：观察游泳运动对自发性高血压大鼠心肌间质形态学及TGF-β1/Smad3信号通路的影响。方法：选取8只SPF级雄性WKY大鼠为正常对照组（C组）;20只SPF级自发性高血压大鼠随机分为模型组（H组）和SHR+运动组（EH组）,每组均10只,各组大鼠给予普通饲料喂养。运动组大鼠进行为期12周不负重游泳训练,每周训练6天,休息1天。第1周为适应性训练,从第2周开始维持60 min/d的运动时间至12周结束。干预周期结束后检测检测各组大鼠CVF%、col I和col III;QRT-PCR检测心肌Smad3,放免法检测AngII,Western-blot法检测NOX2、TGF-β1、HSP90蛋白表达。结果：（1）C组比较,H组大鼠心肌CVF%、colI、colIII、血浆AngII、心肌AngII、心肌NOX2、TGF-β1、Smad3mRNA、HSP90表达显著性增加（P<0.05或P<0.01）;与H组比较,EH组大鼠除了心肌HSP90蛋白表达显著性增加外（P<0.05）,其余指标均显著性降低（P<0.05或P<0.01）。结论：游泳运动能较好降低SHR大鼠心肌col I和col III蛋白表达水平,改善心肌间质纤维化,主要通过降低AngII介导NOX2表达,抑制下游TGF-β1/Smad3通路激活,其中HSP90作为其上游因子,在其中可能起着重要的调节作用。 相似文献