High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice     

Xiaochuan Zhang  Xianzhen Yin  Jingjing Zhang  Anan Li  Hui Gong  Qingming Luo  Haiyan Zhang  Zhaobing Gao  Hualiang Jiang 《国家科学评论(英文版)》2019,6(6):1223

Accumulating evidence indicates the critical importance of cerebrovascular dysfunction in the pathogenesis of Alzheimer''s disease (AD). However, systematic comparative studies on the precise brain vasculature of wild-type and AD model mice are still rare. Using an image-optimization method for analysing Micro-Optical Sectioning Tomography (MOST) data, we generated cross-scale whole-brain 3D atlases that cover the entire vascular system from large vessels down to smallest capillaries at submicron resolution, for both wild-type mice and a transgenic (APP/PS1) mouse model of AD. In addition to distinct vascular patterns in different brain regions, we found that the main vessels of the molecular layer of the hippocampal dentate gyrus (DG-ml) undergo abrupt changes in both diameter and branch angle, spreading a unique comb-like pattern of capillaries. By using a quantitative analysis workflow, we identified in the hippocampus of AD mice an overall reduction of the mean vascular diameter, volume fraction and branch angle, with most significant impairment in the DG-ml. In addition, virtual endoscopy revealed irregular morphological features in the vessel lumen of the AD mice, potentially contributing to the impairment of blood flow. Our results demonstrate the capability of high-resolution cross-scale evaluation of brain vasculature and underscore the importance of studying hippocampal microcirculation for understanding AD pathogenesis.  相似文献   

An end-to-end deep generative approach with meta-learning optimization for zero-shot object classification     

《Information processing & management》2023,60(2):103233

Zero-shot object classification aims to recognize the object of unseen classes whose supervised data are unavailable in the training stage. Recent zero-shot learning (ZSL) methods usually propose to generate new supervised data for unseen classes by designing various deep generative networks. In this paper, we propose an end-to-end deep generative ZSL approach that trains the data generation module and object classification module jointly, rather than separately as in the majority of existing generation-based ZSL methods. Due to the ZSL assumption that unseen data are unavailable in the training stage, the distribution of generated unseen data will shift to the distribution of seen data, and subsequently causes the projection domain shift problem. Therefore, we further design a novel meta-learning optimization model to improve the proposed generation-based ZSL approach, where the parameters initialization and the parameters update algorithm are meta-learned to assist model convergence. We evaluate the proposed approach on five standard ZSL datasets. The average accuracy increased by the proposed jointly training strategy is 2.7% and 23.0% for the standard ZSL task and generalized ZSL task respectively, and the meta-learning optimization further improves the accuracy by 5.0% and 2.1% on two ZSL tasks respectively. Experimental results demonstrate that the proposed approach has significant superiority in various ZSL tasks.  相似文献   

中小学线上教育影响因素及优化建议探究     

陆俊余 《科教文汇》2021,(10):138-140

在“互联网+教育”的背景下,教育信息化助推线上教育飞速发展,线上教育是推进教育课程改革、教育公平、教育普及的有效手段。中小学线上教育发展的影响因素包括学生身心发展特点、教育形式及内容、家庭教育环境、资源配置、投入力度等。新时代背景下,应坚持以发展、兴趣和需求为主,选择合适的线上教育课程;坚持“以人为本”的核心理念,提升线上教育质量内涵;重视家校合作,提高线上教育质量;加强数字资源配置,优化线上教育环境。这对促进中小学线上教育发展有着积极的作用。  相似文献   

民族传统体育文化面临的安全威胁及其应对策略分析     

苏荣 《体育科技文献通报》2020,(5):127-127,142

文化激进主义、西方体育文化的强势进入以及我国文化发展动力的不足是我国体育文化发展面临的问题,这些问题都是我国民族传统体育文化所面临的安全威胁。为了更好地解决这些问题可以采用的方式包括加大对文化的宣传,提升文化保护意识,积极地调整文化发展的策略,积极地完善相应地文化保护政策,转化文化发展模式,这样就能够更好地加强民族传统体育文化的保护,提升其文化创作的活力,以此来更好地促进民族传统体育产业的发展。  相似文献   

Making Video News Visible: Identifying the Optimization Strategies of the Cybermedia on YouTube Using Web Metrics     

Carlos Lopezosa  Enrique Orduna-Malea  Mario Pérez-Montoro 《Journalism Practice》2020,14(4):465-482

  相似文献   

提高小学数学学困生成绩点滴谈     

魏敦姬 《教育教学论坛》2020,(3):315-316

通过“心与心的交流和方法与方式的优化”两个方面来阐述如何轻松、愉快、有效、合理地提高小学数学学困生的教学质量。  相似文献   

基于NSGAⅡ的带时间窗生鲜品配送路径优化     

李善俊  陈淮莉 《上海海事大学学报》2020,41(2):58-64

考虑到生鲜品的易腐性、高时效性和对运输环境要求高的特点,为减少生鲜品配送企业的配送成本,提高客户满意度,在车辆载重、时间窗、生鲜品保质期等约束条件下,提出将配送总成本最小化和生鲜品新鲜度最大化的多目标车辆路径优化模型。利用改进的非支配排序遗传算法(non-dominated sorting genetic algorithmⅡ,NSGAⅡ)对模型进行求解。求出满足配送总成本最小和生鲜品新鲜度最大的相对较优解,证明模型的有效性。该模型在大规模配送和客户地理位置分布较为分散的情况下,对生鲜品新鲜度的优化较为明显。  相似文献   

非稳态雾赋能网络中的在线任务卸载方法     

朱兆伟  刘婷  钱骅  罗喜良 《中国科学院大学学报》2020,37(5):699-707

为充分发掘分布在不同位置上的雾节点的计算资源，任务卸载被寄予众望。在雾计算场景下，以尽可能减少任务卸载的长期成本为目标，试图寻找一个高效的在线任务卸载方法。为此，这一问题被建模成一个随机规划问题，该问题中系统参数所对应的随机变量的期望会在未知时刻突变，系统参数相关信息只能在任务完成后的反馈中获得。基于非稳态多臂老虎机模型，提出一个高效的算法来解决这一具有挑战性的随机优化问题，给出理论分析证明该算法的渐进最优性。数值实验证明了该算法的优越性。  相似文献   

中国足球超级联赛U23新政何以有效?——基于“足协-俱乐部”的博弈     

花楷  刘晓宇  胡凯  隆丽珊 《武汉体育学院学报》2020,54(8):72-80

中超联赛自2017赛季推出U23新政以来备受争议。在"上有政策下有对策"的非合作博弈下，U23新政如何才能实现政策初衷?该文首次采用不完全信息静态博弈模型分析了U23新政下足协与俱乐部的博弈均衡。研究表明：（1）足协推行新政的最优概率为俱乐部采取积极策略给足协带来的净收益与消极策略带来的净收益之比，实质上取决于俱乐部的遵从度。（2）在缺乏讨价还价权时，俱乐部对新政采取消极应对策略是为了减少净损失。俱乐部积极应对的最优概率为消极应对的净损失占其与积极应对的加成即期收益损失之和的比值，实为两害相权取其轻。为激励俱乐部采取积极策略，应降低俱乐部消极应对策略的净收益或积极应对策略的加成即期收益。（3）提高U23新政有效性的治标之策是减少U23政策对中下游球队的冲击，实行有差别的U23政策；对U23球员上场时间低于均值的俱乐部，实行等额或超额递减分成机制。治本之策是培育一个可预期、可持续、可盈利的足球市场，俱乐部能够内生出建立百年基业的长效机制；继续深化足协的去行政化改革，使之向完全社团法人转型。  相似文献   

Evaluation of the optimum pre-stressing pressure and wall thickness determination of thick-walled spherical vessels under internal pressure     

M.H. Kargarnovin  H. Darijani  R. Naghdabadi 《Journal of The Franklin Institute》2007,344(5):439-451

In the present study, in the first part for a spherical vessel with known dimensions and working pressure, two methods of hoop and equivalent stress optimization across the wall thickness are employed to determine the best autofrettage pressure. In the next part for a predefined working pressure the minimum wall thickness of the vessel is calculated using two other design criteria i.e. (A) optimizing the hoop stress, and (B) assuming a suitable percent for the penetration of yielding within the wall thickness. Finally, the optimum thickness and the necessary strengthening pressure are extracted and different plots are introduced for different types of structural materials under different internal pressures.  相似文献