首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   11篇
  免费   0篇
教育   4篇
科学研究   3篇
信息传播   4篇
  2019年   2篇
  2014年   1篇
  2013年   3篇
  2012年   2篇
  2009年   1篇
  2008年   1篇
  2004年   1篇
排序方式: 共有11条查询结果,搜索用时 15 毫秒
1.
Lu  Ying-Ying  Hu  Chieh-Fang 《Reading and writing》2019,32(4):891-908
Reading and Writing - Dynamic assessment has been recognized as a nonbiased approach to evaluating language learning potential among children who do not have equal access to the target language....  相似文献   
2.
从芸香科植物黄皮叶中分离出具有五种不同骨架的七个新酰胺类化合物,其中之一的黄皮酰胺的γ-内酰胺与具有促智作用的脑复康(piracetam)呈现相同的骨架,其分子中有4个不对称中心,应有16个对映体。在鉴定出16个对映体的绝对构型之后,用黄量教授设计的仿生路线先后完成了16个对映体和光活黄皮酰胺的不对称合成,在这一研究中解决了立体化学和合成中的一些难点,大大缩短了合成步骤,提高了总得率,生产工艺日趋成熟,其合成规模可满足临床试用和日后治疗疾病的需要。使用多项模型和指标也已证明(一)黄皮酰胺是有效对映体,(+)黄皮酰胺为劣对映体。黄皮酰胺对映体的代谢(血药浓度、吸收、分布、排泄、血浆蛋白结合、肝脏首过效应)和酶促动力学也都存在立体选择性差异。(一)黄皮酰胺的主要药理作用是改善认知功能和抑制Ap毒性。药理作用的显著特点是提高突触效能和结构的可塑性,为国际上近年提出的“突触丢失是老年痴呆的主要原因”的新学说提供了有力的支持,也为当前AD治疗的新策略提供了有良好前景的新药。  相似文献   
3.
4.
分析高校科研团队知识共享社会网络特性,认为它是一个典型的1-模社会网,并以某高校系统工程科研团队为例,假设科研团队内成员之间每共同拥有一项科研成果,即认为彼此之间发生一次知识共享活动,在此基础上收集整个科研团队近5年的相关数据,构建了该科研团队知识共享的社会网络;从整体网的视角对该科研团队知识共享能力进行了具体研究,主要包括网络黏性测量、中心性测量、核心—边缘测量、凝聚子群,以及结构洞测量等五个方面的内容;对五个测量结果进行分析并给出了提高高校科研团队知识共享水平的建议。  相似文献   
5.
6.
ABSTRACT

This article deals with collaborative projects carried out in co‐operation with teacher‐training/Higher Education institutions and schools around the world. Partners for these links included the University of Helsinki (Finland), City College (New York, USA), the Academy of Sciences (Moscow, Russia) and the University of Oldenburg (Germany). A rationale is offered for the use of telecommunications, especially electronic mail, in co‐operative projects of this kind and the potential is explored for further networks with research and development aspects. The article draws upon previous presentations and discussions at conferences in Germany, Australia, USA and the United Kingdom. Recent developments concerning links between initial teacher education and schools in Britain are examined briefly and suggestions offered for ways in which electronic mail can facilitate such links.  相似文献   
7.
Consumer magazine publishers gathered at the Magazine Publishers of America 24|7 5th Digital Conference in New York on March 3, 2009. With print trending downwards, attendees heard about the continuing boom of digital in the magazine industry. Discussions included how to better monetize websites, bridge the division between editorial and business, trends in new products, and strategic planning, marketing and advertising on the Internet.  相似文献   
8.
9.
The objective of this work is the development of an automatic and mobile X-ray robot that is becoming necessary in a changing environment (aging society, growth of the developing countries, etc.). Specifically, there are three sides to such a project. First, there is the mechanical side, i.e. the design and implementation of motors on every mobile part of an X-ray unit allowing it to move around a standing patient. Then, comes the electronic side, i.e. the use of potentiometers and limit switches as feedback combined with microcontrollers. And last, the algorithm that computes three-dimensional models from two-dimensional X-rays.  相似文献   
10.
BackgroundJuglone is a naphthoquinone currently obtained by chemical synthesis with biological activities including antitumor activity. Additionally, juglone is present in the green husk of walnut, which suggests evaluating the effect of GH extracts on carcinogenic cell lines.ResultsWalnut green husk ethanolic extract was obtained as 169.1 mg juglone/100 g Green Husk and antioxidant activity (ORAC) of 44,920 μmol Trolox Equivalent/100 g DW Green Husk. At 1 μM juglone in HL-60 cell culture, green husk extract showed an antiproliferative effect, but pure juglone did not; under these conditions, normal fibroblast cells were not affected. A dose-dependent effect on mitochondrial membrane potential loss was observed. Apoptosis of HL-60 was detected at 10 μM juglone. Despite high ORAC values, neither purified juglone nor the extract showed protective effects on HL-60 cells under oxidative conditions.ConclusionsGreen husk extract generates an antiproliferative effect in HL-60 cells, which is related to an induction of the early stages of apoptosis and a loss of mitochondrial membrane potential. The normal cells were not affected when juglone is present at concentrations of 1 μM, while at higher concentrations, there is loss of viability of both cancerous and healthy cells.How to cite: Soto-Maldonado C, Vergara-Castro M, Jara-Quezada J, et al. Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis. Electron J Biotechnol 2019;39. https://doi.org/10.1016/j.ejbt.2019.02.001.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号