Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

【新水令】曲牌风格流变探析     

王方好  阎方正 《保定学院学报》2020,(1):85-91

曲牌【新水令】由同名词牌演化而来,最初被运用在南戏《张协状元》之中,用于表达慷慨激越的感情风格。该曲牌具有较强的灵活性,从元代到清代,其题材不断被拓宽,感情色彩也不断发生变化,不再局限于慷慨激越的声情风格,表达的情感也更为丰富。分析梳理【新水令】这一曲牌在元明清三代的风格变化,可以对其有更为深入的了解,亦有助于对于曲史样式的研究。  相似文献   

习近平新时代体育强国思想的马克思唯物主义立场及价值引领     

赵富学 《武汉体育学院学报》2019,53(2):5-11

运用文献资料法、辩证分析法、逻辑推理法等研究方法，对习近平新时代体育强国思想的马克思唯物主义立场进行了演绎与阐释。研究认为：在马克思唯物主义立场层面，习近平新时代体育强国思想坚持体育强国梦与实现中华民族伟大复兴中国梦一脉相承的历史唯物主义立场和普遍联系的辩证唯物主义立场；坚持在体育强国建设进程中遵循问题导向的唯物主义本体论立场；坚持体育强国建设要利用好国际与国内两种资源的唯物主义内外因辩证关系的立场。在新的历史时期，习近平新时代体育强国思想引领着竞技体育、群众体育、体育产业等领域的发展理念和价值，创新与发展了马克思主义哲学的实践结构和理论视角，为开创新时代中国特色社会主义体育事业的新局面提供了坚实的理论基础和实践支持。  相似文献   

Professional knowledge or motivation? Investigating the role of teachers’ expertise on the quality of technology-enhanced lesson plans     

《Learning and Instruction》2020

In an expertise study with 94 mathematics teachers varying in their relative teacher expertise (i.e., student teachers, trainee teachers, in-service teachers), we examined effects of teachers' professional knowledge and motivational beliefs on their ability to integrate technology within a lesson plan scenario. Therefore, we assessed teachers' professional knowledge (i.e., content knowledge, pedagogical content knowledge, technological knowledge), and their motivational beliefs (i.e., self-efficacy, utility-value). Furthermore, teachers were asked to develop a lesson plan for introducing the Pythagorean theorem to secondary students. Lesson plans by advanced teachers (i.e., trainee teachers, in-service teachers) comprised higher levels of instructional quality and technology exploitation than the ones of novice teachers (i.e., pre-service teachers). The effect of expertise was mediated by teachers' perceived utility-value of educational technology, but not by their professional knowledge. These findings suggest that teachers’ motivational beliefs play a crucial role for effectively applying technology in mathematics instruction.  相似文献   

The effect of number of siblings and birth order on educational attainment: Empirical Evidence from Chinese General Social Survey     

《International Journal of Educational Development》2020

Data from China demonstrate that the effect of the number of siblings on education is restricted by many factors, such as children’s gender, urban or rural household registration, whether there is only one child, the birth order of children within the family, and parents’ status. Chinese families have significant preferences for the eldest son and the youngest son. Moreover, research based on the natural experiment and instrumental variable approach suggests that market-oriented reform of education has increased the cost of family education expenditures since China’s reform and opening up, which further aggravates the negative impact on education of having many siblings in an urban setting.  相似文献   

图书馆网络期刊的两种编目方式及其选择   总被引：1，自引：0，他引：1  

郑雯  吕肖华 《图书情报工作》2003,47(8):61-65

对图书馆网络期刊的两种编目方式集中编目与分散编目进行比较。根据网络期刊的内容和图书馆的具体情况,探讨如何在实际工作中选择这两种编目方式,并提出相关的建议。  相似文献   

论新疆旅游资源开发及旅游业发展问题   总被引：4，自引：0，他引：4  

于志远  林双成 《天水师范学院学报》2003,23(1):86-88

新疆旅游资源丰富多彩 ,极具特色。上世纪 90年代以来 ,旅游业虽有较快发展 ,但仍不发达 ,与自身的资源优势极不相称。新疆旅游业要在 2 1世纪获得发展 ,必须彻底转变观念、科学规划、整体优化布局 ,多方面采取措施  相似文献   

电视新闻策划的实践思考     

夏冰 《浙江传媒学院学报》2003,10(3):18-20

新闻策划是对新闻报道活动的策划,电视新闻策划是现代社会受众和电视自身发展的需要。电视新闻的策划重在发挥电 视传播的优势,强调整体的协作。  相似文献   

中国竞技体育人力资源相关问题探讨   总被引：5，自引：0，他引：5  

肖林鹏  赵云宏  张兆青  骆意 《广州体育学院学报》2003,23(6):8-9

对竞技体育人力资源的概念、特点等问题进行了探讨：研究表明，竞技体育人力资源是指竞技体育发展所需人员的现实及潜在禀赋的总和。处于不同层次、不同领域的众多人员组成了竞技体育人力资源系统：竞技人力资源具有稀缺性、目标性、整体性及调控性等特点.  相似文献   

马来西亚华文独中学校体育的现状与未来     

韩会君  林敏萍 《体育科研》2003,24(3):59-62

本着弘扬民族文化的基本思想,运用文献资料研究、问卷调查、数理统计等方法,对马来西亚华文独中学校体育的现状进行了客观的分析,并在现状分析的基础上对马来西亚华文独中学校体育的进一步发展提出了建设性的意见。  相似文献