Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

对刊文《科技管理研究》的计量分析——基于知识图谱视角     

赖志杰  李炳超  李细金  黄宝强 《科技管理研究》2018,(14)

本文通过在CNKI数据库中搜索了来源期刊为《科技管理研究》(2003-2016.9)的相关文献,运用科学计量分析方法,对其现状和研究热点进行了分析。研究发现,技术创新、影响因素、知识产权、产业集聚、指标体系、科技创新等都是近年来研究的热门话题。  相似文献   

研发费用加计扣除是否提升了企业创新能力?——创新链全视角          下载免费PDF全文

冯泽  陈凯华  戴小勇 《科研管理》2019,40(10):73-86

现有关税收优惠政策对企业创新活动影响的文献缺乏从整个创新链的全角度揭示税收优惠政策是否真正提高企业创新能力的探索。基于中关村科技型企业数据，本文选取税收优惠政策中典型的政策工具“研发费用加计扣除”作为研究对象，有别于已有主要从“投入”视角关注研发费用加计扣除引导作用的研究，从“投入-产出-收益”的创新链全视角，将创新过程分为技术研发阶段与技术转化阶段，以揭示研发费用加计扣除政策是否真的提升了企业创新能力。基于PSM-DID方法的实证研究结果发现：在投入端，研发费用加计扣除政策显著提高了企业的研发投入规模与强度；在产出端，研发费用加计扣除政策仅促进了研发产出规模的提升，而对于产出强度则无显著影响；在收益端，研发费用加计扣除对收益规模与强度同样有显著的促进作用。本文的发现肯定了我国研发费用加计扣除政策的引导作用，以及其在企业创新能力提升中发挥的积极作用。本文的研究思路为揭示政府创新激励政策的效果提供了新视角，研究发现为从创新链与企业创新能力的角度思考和改善政府研发税收优惠政策的管理和实施提供了新证据。  相似文献   

外部网络关系对企业双元创新的影响——基于知识视角的分析     

庞娟  靳书默 《科技管理研究》2019,39(11)

外部网络关系对企业双元创新的影响结果存在较大争议,企业维持何种状态的外部网络关系会促进双元创新,影响机理中知识吸收能力起到怎样的作用,这是亟需研究的问题。对387家企业为样本进行问卷调查,运用结构方程模型法,以知识获取能力和知识实现能力为双重中介,探析外部网络关系对企业双元创新的影响。研究结果表明：外部网络关系不同维度对双元创新具有差异化影响；网络关系强度和网络关系密度的提高以及网络关系深度的适度降低有利于渐进性创新,网络关系深度和网络关系密度的提高以及网络关系强度的适度降低更有利于突破性创新；知识吸收能力在外部网络关系对双元创新的影响中发挥部分中介作用。  相似文献   

Search tactics used in solving everyday how-to technical tasks: Repertoire,selection and tenacity     

Sophie Rutter  Verena Blinzler  Chaoyu Ye  Max L. Wilson  Michael D. Twidale 《Information processing & management》2019,56(3):919-938

With greater access to computational resources, people use search to address many everyday challenges in their lives, including solving technology problems. Although there are now many useful ‘how-to’ resources online (especially videos on YouTube), it can still be difficult to identify, understand, and resolve certain kinds of technical problem. While research tasks have been studied for many years and we know the tactics people use, we know far less about searchers’ tactics for how-to technical tasks that involve actually being able to apply found information to resolve a problem. Crucial to our study was developing and studying a highly realistic, how-to technical task, for which there was no single guidance resource: making a phone safe for a child. After providing 39 participants with an actual phone to fix, and a search engine to perform the task, we analysed their search tactics using retrospective cued think aloud interviews. Our primary contribution is a set of 77 tactics used, in three categories, along with detail of how common they were. We conclude that people had a lot of tactics in their repertoire. Although it was not hard for participants to find relevant information, what was hard was for participants to find information they could use; indeed only 23% of participants successfully completed the entire task. Domain knowledge affected the choice of tactics used (although not necessarily towards better task success). We discuss these influences and make design recommendations for how future search systems can support those in resolving how-to technical tasks.  相似文献   

Paternal support for child sexual abuse victims: A qualitative study     

《Child abuse & neglect》2019

BackgroundThe current state of knowledge regarding the role of non-offending fathers in supporting their sexually abused children is very scarce.ObjectiveThe objective of this study is to further our understanding of fathers’ roles following disclosure of their children’s sexual abuse (SA) by evaluating fathers’ perceptions of the impact of disclosure on their involvement and support of their children.Participants and methodThis qualitative study relies on individual semi-structured interviews conducted with 17 fathers of allegedly abused children.ResultsInductive thematic analysis first highlighted that some reported a period of disengagement from the child during which they put into question their role and attitudes, followed by a period of re-involvement. This period of difficulties experienced by some fathers in regard to their involvement towards their children was due to either their own important psychological distress, their ambivalence towards their child or even because of feelings of uneasiness experienced during physical contact with them. Despite this, findings indicate the presence of thoughts and attitudes that suggest children are a source of concern for fathers. The four forms of abuse-specific support previously observed among mothers (believing the child, seeking out professional services, protecting him/her from the offender, supporting him/her emotionally) were also observed among fathers. In accordance with the activation theory, a form of support specific to fathers, namely, encouraging the child to open up to and explore the world outside the family, thereby, fostering the child’s self-esteem development, was observed and constitutes a relevant finding.ConclusionClinical and empirical implications are discussed.  相似文献   

企业协同创新理论框架及其知识互动影响因素述评     

肖琳  徐升华  杨同华 《科技管理研究》2018,(13)

为探索企业协同创新的新理论模型,为企业协同创新活动和做好知识互动提供理论依据和指导,建立协同创新过程中知识互动的影响因素模型。通过文献阅读法整理前人关于协同创新理论的研究,并总结和评述,探索性提出协同创新的一种新的理论框架,将协同创新进行三阶段划分,协同创新过程中知识互动的效果直接影响创新绩效,进一步探究协同创新中知识互动的要素,梳理和评述每一种知识互动影响因素的研究观点,并建立协同创新不同阶段的影响因素模型,这为下一步影响因素的权重的实证研究做好铺垫。  相似文献   

《中国卫生统计杂志》Meta分析类稿件退稿原因及审稿策略     

刘壮  张悦 《中国科技期刊研究》2018,29(4):368-373

【目的】 为期刊编辑及时、准确地处理Meta分析类稿件提供参考依据，以期提高期刊编辑的工作效率和期刊来稿质量。【方法】 调查2011年11月1日—2017年11月1日《中国卫生统计杂志》在线投稿系统中Meta分析类稿件，深入分析119篇样本稿件的审理过程，归纳退稿原因并总结审稿策略。【结果】 119篇稿件中，仅33篇稿件已发表，20篇稿件仍在审理过程中，66篇稿件被退稿。退稿原因包括选题创新性差、文献检索不当、文献纳入与排除标准不严谨、流程图不规范、异质性分析不当、发表偏倚分析不当、讨论欠佳等。【结论】 编辑审读Meta分析类稿件时，应加强主题选取和相关文献的搜集、纳入文献的筛选方法及质量评价、数据的统计学处理和结果解释4个方面的审查，减少不合格文献的数量。  相似文献   

SSCI收录期刊不同学科Article和Review参考文献量的差异性分析     

盛丽娜  顾欢 《中国科技期刊研究》2018,29(11):1153-1159

【目的】 以SSCI的学科分类为单位，分析不同学科期刊的Article和Review参考文献量的差异，以利于相关人员了解及借鉴，同时为进一步从文后参考文献的角度更深入了解现行期刊评价指标的优缺点提供数据支持。【方法】 分学科下载2015年SSCI收录期刊的主要文献计量学指标，同时记录各刊在学科内的分区及各刊Article和Review的平均参考文献量，Spearman等级秩相关性分析用于分析各学科Article和Review的参考文献量与学科各评价指标的相关性。【结果】 2015年SSCI共收录了57个学科的4468种期刊，Article和Review的参考文献量与学科规模的大小均不相关(均为P>0.05)；学科内Article和Review的参考文献量由多到少排序，依次为Q1区(60.27条、86.85条)、Q2区(52.21条、83.80条)、Q3区(48.16条、74.61条)、Q4区(45.70条、62.90条)，且差异均有统计学意义(均为P<0.05)。相关性分析结果表明，Article参考文献量仅与学科中位被引半衰期和学科中位引用半衰期存在相关性；Review参考文献量除与学科中位被引半衰期不存在相关性外，与其他主要期刊评价指标均有相关性(均为P<0.05)。【结论】 按SSCI学科分组，Article和Review参考文献量与学科影响力的关系并不一致，二者与学科规模均不相关；同一学科影响力较大期刊的Article和Review参考文献量相对较多。  相似文献   

新常态下政府主导科技体制改革深化的阶段性研究     

黄宇 《科技管理研究》2018,(8)

根据新常态下国家中长期社会经济发展对科技创新的战略定位,立足宏观科技管理的基本规律,紧紧围绕科技与经济脱节的核心矛盾,具体阐述我国现行科技体制存在的问题及原因。在全面梳理党的十八大以来国家以转变政府职能和调整公共政策为抓手的系列关键举措及其成效基础上,从剖析现阶段科技体制改革深化的结构性本质入手,结合科技强国目标的实现,为后续工作的推进提出对策和建议。  相似文献