Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Knowledge representation learning with entity descriptions,hierarchical types,and textual relations     

Xing Tang  Ling Chen  Jun Cui  Baogang Wei 《Information processing & management》2019,56(3):809-822

  相似文献   

Paternal support for child sexual abuse victims: A qualitative study     

《Child abuse & neglect》2019

BackgroundThe current state of knowledge regarding the role of non-offending fathers in supporting their sexually abused children is very scarce.ObjectiveThe objective of this study is to further our understanding of fathers’ roles following disclosure of their children’s sexual abuse (SA) by evaluating fathers’ perceptions of the impact of disclosure on their involvement and support of their children.Participants and methodThis qualitative study relies on individual semi-structured interviews conducted with 17 fathers of allegedly abused children.ResultsInductive thematic analysis first highlighted that some reported a period of disengagement from the child during which they put into question their role and attitudes, followed by a period of re-involvement. This period of difficulties experienced by some fathers in regard to their involvement towards their children was due to either their own important psychological distress, their ambivalence towards their child or even because of feelings of uneasiness experienced during physical contact with them. Despite this, findings indicate the presence of thoughts and attitudes that suggest children are a source of concern for fathers. The four forms of abuse-specific support previously observed among mothers (believing the child, seeking out professional services, protecting him/her from the offender, supporting him/her emotionally) were also observed among fathers. In accordance with the activation theory, a form of support specific to fathers, namely, encouraging the child to open up to and explore the world outside the family, thereby, fostering the child’s self-esteem development, was observed and constitutes a relevant finding.ConclusionClinical and empirical implications are discussed.  相似文献   

欧洲九国共产党情报局机关刊物《争取持久和平,争取人民民主!》与中国关系考述(1949-1956)     

哈战荣 《图书馆杂志》2020,(4):21-26

《争取持久和平,争取人民民主!》是20世纪40年代中后期,欧洲九个社会主义国家的共产党和工人党为了一致行动而建立的情报局机关刊物。该刊物对新中国初期我国经济社会建设及成就进行了大量宣传与报道,对加强我国与世界其他爱好和平、渴求民主的各国人民加强互信、长存友谊贡献很大,也对当前学者研究新中国初期我国经济社会发展的过程、成就和经验等提供了原始史料,学术研究意义也很重大。但是,目前对这份刊物及其发挥过的重大作用了解的人少之又少,时值中国共产党成立100周年之际,对其创刊与发行的历史过程进行回顾、宣传中国社会经济发展的全貌进行展示、推动世界社会主义运动的作用进行肯定,意义都很重大。  相似文献   

试论《明人十二像册》高度写真风格的中国渊源     

黄乐乐 《美育学刊》2020,11(2):116-120

现藏于南京博物院的一批无款写真头像《明人十二像册》,是中国写实画的一座高峰。对于这个像册的绘画风格,现当代学者多半都偏向认为是受到西方绘画的影响。但经与西方圣像画比较研究,像册仍属于中国本土的绘画传统,受到了宋代山水画和花鸟画高度写真精神的影响。  相似文献   

Using an interactive platform to recognize the intersection of social and spatial inequalities     

Lisa Poling  Travis Weiland 《Teaching Statistics》2020,42(3):108-116

With the creation of interactive tasks that allow students to explore spatial ways of knowing in conjunction with their other ways of knowing the world, we create a space where students can make sense of information as they organize these new ideas into their already existing schema. Through the use of a Common Online Data Analysis Platform (CODAP) and data from Public Use Microdata Areas (PUMA), students can explore the communities in which they live and work, critically examining opportunities and challenges within a defined space.  相似文献   

坦桑尼亚县域与城乡交通通达水平空间格局特征     

张家旗  陈爽  高群  ISMAEL A. Kimirei 《中国科学院大学学报》2019,36(6):766-773

坦桑尼亚是"一带一路"倡议通向非洲、辐射非洲内陆的重要门户，它在快速城市化过程中面临交通基础设施严重短缺问题。基于坦桑尼亚公路、铁路、机场、港口、人口和城市分布数据，运用GIS空间分析技术，结合交通通达指数模型，从县域与城乡两个层面对坦桑尼亚交通通达水平的空间格局特征进行定量分析。研究发现：1）坦桑尼亚县域交通通达水平空间分布极不均衡，高值连片区主要位于东北沿海和维多利亚湖沿岸，低值连片区主要位于中央铁路线中段以北、中央铁路线南部的广大地区；2）受地理区位、资源禀赋、殖民历史、政府政策等影响，城市与乡村地区之间的交通通达水平差异十分显著。研究结果有助于坦桑尼亚制定区域交通发展政策和优化资源配置，同时对中-坦产业精准对接和产能转移具有一定的促进意义。  相似文献   

基于平昌冬奥会赛况及主场优势对我国雪车和钢架雪车发展的启示          下载免费PDF全文

武林志  唐琨  段玉丞 《体育科研》2019,(3):15-19

通过分析平昌冬奥会雪车和钢架雪车的赛况及主场优势，探索雪车和钢架雪车的发展规律，力求为我国雪车和钢架雪车项目的发展提供借鉴和参考。收集整理雪车和钢架雪车项目基本信息、平昌冬奥会赛况、获奖运动员信息及主场优势。研究发现：平昌冬奥会雪车和钢架雪车项目获奖运动员身材高大、年龄偏高；雪车和钢架雪车项目运动员跨界、跨项比例非常高；初学雪车和钢架雪车的年龄与运动成绩无直接联系，有丰富运动经历、运动水平较高、年龄略小（20岁以下）的其他项目运动员（田径）可转雪车和钢架雪车，且运动成绩提升速度快，通常在训练两年后，可达世界高级水平；雪车和钢架雪车训练和比赛的赛道极其稀缺，有限的赛道集中在东道主国家，这些国家的运动员较其他国家运动员有更多的时间熟悉赛道，这可能在一定程度上增加获胜的几率。  相似文献   

Understanding the topic evolution of scientific literatures like an evolving city: Using Google Word2Vec model and spatial autocorrelation analysis     

Kai Hu  Qing Luo  Kunlun Qi  Siluo Yang  Jin Mao  Xiaokang Fu  Jie Zheng  Huayi Wu  Ya Guo  Qibing Zhu 《Information processing & management》2019,56(4):1185-1203

Topic evolution has been described by many approaches from a macro level to a detail level, by extracting topic dynamics from text in literature and other media types. However, why the evolution happens is less studied. In this paper, we focus on whether and how the keyword semantics can invoke or affect the topic evolution. We assume that the semantic relatedness among the keywords can affect topic popularity during literature surveying and citing process, thus invoking evolution. However, the assumption is needed to be confirmed in an approach that fully considers the semantic interactions among topics. Traditional topic evolution analyses in scientometric domains cannot provide such support because of using limited semantic meanings. To address this problem, we apply the Google Word2Vec, a deep learning language model, to enhance the keywords with more complete semantic information. We further develop the semantic space as an urban geographic space. We analyze the topic evolution geographically using the measures of spatial autocorrelation, as if keywords are the changing lands in an evolving city. The keyword citations (keyword citation counts one when the paper containing this keyword obtains a citation) are used as an indicator of keyword popularity. Using the bibliographical datasets of the geographical natural hazard field, experimental results demonstrate that in some local areas, the popularity of keywords is affecting that of the surrounding keywords. However, there are no significant impacts on the evolution of all keywords. The spatial autocorrelation analysis identifies the interaction patterns (including High-High leading, High-Low suppressing) among the keywords in local areas. This approach can be regarded as an analyzing framework borrowed from geospatial modeling. Moreover, the prediction results in local areas are demonstrated to be more accurate if considering the spatial autocorrelations.  相似文献   

国外知识组织体系管理工具比较分析与启示     

纪姗姗  赵炳容  刘峥 《图书情报工作》2021,64(24):73-83

[目的/意义] 比较分析语义网技术发展环境下国外代表性知识组织体系管理工具的研究现状及关键功能，梳理相关研究的发展趋势。[方法/过程] 通过网络调研法，遴选国外10个代表性知识组织体系管理工具，从结构定义、项目维护、数据管理、互操作性、操作环境等方面比较分析其发展现状。在此基础上，为国内知识组织体系管理工具的建设工作提供建议。[结果/结论] 研究发现，国内知识组织体系管理工具的建设工作应依托语义网、关联数据、语义集成、语义互操作等技术促进功能创新，包括：灵活设计并配置多类型数据模型、支持可持续发展的管理与维护机制、支持用户分布式协同管理与控制、知识驱动的数据迭代式更新、面向语义的KOS重用与进化、建设以KOS为核心的知识组织框架等。  相似文献