排序方式： 共有4条查询结果，搜索用时 7 毫秒
1
1.
Objective: To investigate changes in magnetic resonance spectroscopy (MRS) of lentiform nucleus during the early stage of Parkinson's disease. Methods: Twenty-five patients with idiopathic Parkinson disease with unilateral symptoms (IPDUS) and 25 healthy volunteers were enrolled in this study. MRS of the lentiform nucleus in each patient was taken and then concentrations of N-acetylaspartate (NAA), Creatine (Cr) and Choline (Cho) were calculated. Results: Compared to that in the control, NAA/(Cho Cr) was significantly lower in the lentiform nucleus contralateral to symptoms and even that in the ipsilateral side in IPDUS patients (all P＜0.05); while there was no difference between the two sides in the healthy volunteer (P＞0.05). The ratio of NAA/(Cho Cr) ipsilateral to the sympatomatic side of the patient was also lower than that of the control (P＜0.05). Conclusions: there might be some changes with MRS on the lentiform nucleus during the early stage of idiopathic Parkinson's disease with unilateral symptom. MRS may be one of the reliable methods for early or even sub-clinical diagnosis. 相似文献
2.
Objectives: During visual stimulation, the elevated metabolism rate will couple with increase of blood flow velocity(BFV) in posterior cerebral artery(PCA). This study with TCD was aimed to investigate whether the coupling might change according to the different vasoneuronal conditions. Methods: Ninety-nine volunteers including 24 hypertension(HT) patients and 2 patients suffering from both HT and diabetes mellitus(DM) were enrolled in this trial. BFV and pulse indexes(PI) in P2 segments of PCA on both sides were monitored during visual stimulation. Results: In all subjects, Mean BFV increased and PI went down in response to visual stimulation. The percentages of changes (ΔV and ΔP) of both mean BFV and PI were larger in young group(<55 years old) than in old one(≥55 years old). There was significant positive correlation between ΔV and ΔP. Multivariated regression analysis did not show HT and DM, but age related to ΔV(ΔP). We did not find significant difference of ΔV(ΔP) between left and right sides. Conclusions: Blood flow velocity in PCA P2 segment increased due to decreased cerebrovascular resistance during visual stimulation and the response weakened with aging of the patient. 相似文献
3.
ＩＮＴＲＯＤＵＣＴＩＯＮＭａｎｙｉｍａｇｉｎｇｔｅｃｈｎｉｑｕｅｓ,ｌｉｋｅＰＥＴ ,ｆＭＲＩａｎｄＳＰＥＣＴ ,ｃａｎｄｅｍｏｎｓｔｒａｔｅｉｎｃｒｅａｓｅｓｉｎｒｅ ｇｉｏｎａｌｃｅｒｅｂｒａｌｂｌｏｏｄｆｌｏｗ(ＣＢＦ)ｏｒｍｅｔａｂｏｌｉｃｒａｔｅｄｕｒｉｎｇｃｅｒｔａｉｎｎｅｕｒｏｎａｌｓｔｉｍｕｌａｔｉｏｎ .Ｂｕｔｔｈｅｓｅｔｅｃｈｎｉｑｕｅｓａｒｅａｌｗａｙｓｅｘｐｅｎｓｉｖｅａｎｄｍｏｒｅｔｉｍｅｃｏｎｓｕｍｉｎｇａｎｄｒｅｐｅａｔｅｄｍｅａｓｕｒｅｍｅｎｔｓａｒｅｄｉｆｆｉｃｕｌｔ.Ｔ… 相似文献
4.
INTRODUCTION Along with the coming of the aged society, the morbidity of Parkinson抯 disease is also raised. But there is lack of objective experimental diagnostic indexes for it during the early stage. Magnetic resonance spectroscopy (MRS) is a noninvasive technique for measuring the chemical compounds in the human body. 1H MRS can be used to analyze many metabolites, such as N-acetyaspartate (NAA), Creatine (Cr), Choline (Cho) and so on. In Parkin-son抯 disease, the concentratio… 相似文献
1