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1.
S. Narayanan 《Indian journal of clinical biochemistry : IJCB》1996,11(1):12-16
A number of pre analytical variables affect lipid determinations. These include posture during blood sampling, the duration of tourniquet application and fasting, the time of day when blood is collected, the concentration and type of anticoagulant used for blood collection to name just a few. Effect of life style such as diet, alcohol and caffeine consumption, smoking, and exercise influence lipid determinations. Disease states such as infection, diabetes, nephrotic syndrome and heart disease culminating in myocardial infarction and conditions such as obesity and pregnancy influence lipid profiles. A variety of drugs ranging from diuretics to oral contraceptives to immunosuppressive drugs induce alterations in the patient's lipid profile. Post analytical variables impacting on the interpretation of laboratory data such as in the determination of the true mean of a lipid constituent would depend on the number of specimens analyzed, the analytical variability of the method and approaches to handling data such as the use of relative range to estimate the effect of biological variability on the computed mean value. 相似文献
2.
Kannan Vaidyanathan M. P. Narayanan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2011,26(4):319-325
Organic acidurias are an important class of inherited metabolic disorders arising due to defect in intermediary metabolic
pathways of carbohydrate, amino acids and fatty acid oxidation. This review summarizes the current knowledge about the important
organic acidurias in the Indian population. Specifically, diagnosis and principles of treatment of organic acidurias are covered.
The salient features of common organic acidurias as well as their prevalence in various parts of the world are reviewed in
some detail. 相似文献
3.
M. P. Narayanan Vaidyanathan Kannan K. P. Vinayan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2011,26(4):347-353
Organic acid disorders are inherited metabolic disorders in which organic acids accumulate in tissues and biological fluids
of affected individuals. Classical organic acidurias include methylmalonic aciduria, propionic aciduria, isovaleric aciduria
and maple syrup urine disease (MSUD). They are considered the most frequent metabolic disorders among severely ill children.
Patients frequently present with acute symptoms early in life. 420 cases clinically suspected to have organic aciduria, with
upper age limit of 12 years for a 2-year period (January 2007–December 2008) were enrolled into this study. Metabolic acidosis
and neurological symptoms were the most common signs. Screening tests and thin layer chromatography were done for detection
of organic acidurias. Identification and quantitation of organic acids in urine and quantification of amino acids in blood
were done by high performance liquid chromatography. Out of 420 patients, 45 patients (10.7%) were found to have organic acidurias.
15 cases of methylmalonic aciduria, 16 cases of propionic aciduria, 13 cases of MSUD, and one case of isovaleric aciduria
were diagnosed. Results demonstrate the importance of testing for organic acidurias. Since organic aciduria may cause irreversible
brain damage if not treated, we recommend selective screening amongst severely ill children despite implied extra costs. 相似文献
4.
The Cult of Our Lady of Guadalupe, the product of appropriations authored by both the Aztecs and the Roman Catholic Church, has served as a tool of empowerment, dominion, and accommodation. Central to this contested cult is an indigenous reinvention of the Virgin Mary that is simultaneously index, icon, and symbol. This study demonstrates the difficulties in attempting to selectively appropriate the desirable features of such a sign while excluding those deemed undesirable. In attempting to appropriate certain features of the Virgin it deemed desirable, the authors argue, the Church also annexed aspects of the Aztec religious tradition at odds with the teachings of Catholicism. While Catholicism's attempt to co‐opt this Virgin extended the influence of the institutional Catholic Church, the authors suggest, it also undermined the integrity of the faith the Church promotes by fostering a form of popular Catholicism contrary to the teachings and practices of orthodox Catholicism. This study is grounded in data obtained through interviews conducted with pilgrims in the vicinity of the Basilica of Our Lady of Guadalupe immediately prior to, during, and after the Virgin's annual feastday (December 12). The authors also draw upon anthropological, historical, and religious studies scholarship to make sense of the pilgrims’ beliefs and place them within the broader historical and religious contexts in which they operate. 相似文献
5.
Online open source software platforms, such as Sourceforge.net, play a vital role in creating an ecosystem that enables the creation and growth of open source projects. However, there is little research exploring the interactions between open source stakeholders and the platform. We believe that the sustainability of the platform crucially depends on financial incentives. While platforms can obtain these incentives through multiple means, in this paper we focus on one form of financial incentives—voluntary monetary donations by open source community members. We report findings from two empirical studies that examine factors that impact donations. Study 1 investigates the factors that cause some community members to donate and not others. We find that the decision to donate is impacted by relational commitment with open source software platform, donation to projects and accepting donations from others. Study 2 examines what drives the level of donation. We find that the length of association with the platform and relational commitment affects donation levels. 相似文献
6.
Over the past decade, companies worldwide have used corporate venturing (CV) as a means of revitalizing their operations, building new capabilities, and achieving strategic renewal, creating value for shareholders. Business interest in CV has stimulated academic interest in the topic, resulting in a rapidly growing but fragmented body of literature. Despite the growing international scholarly interest in CV, researchers have devoted little effort to integrating prior findings in a cumulative fashion. As a result, studies do not build upon one another, making it difficult to gauge the progress being made in addressing the fundamental research questions related to CV. In this paper, we examine the literature on CV seeking to synthesize, integrate and link its key findings. To do so, we analyze this literature over the past decade to identify its major themes and research findings setting the stage for greater coherence in future research on CV. We give special attention to the challenges and rewards of theory building in future CV research. Our review clearly shows that CV is an area of scholarly inquiry that has important implications for managerial practice. 相似文献
7.
Arvind Chandrasekaran Shanmugasundaram Pakkiriswami Jian Liang You Ashwin Acharya Muthukumaran Packirisamy Denis Maxwell 《Biomicrofluidics》2008,2(3)
90 kDa heat shock protein (HSP90) is a ubiquitous molecular chaperone and is one of the abundant proteins present in a cell under normal and stressed conditions. The adenosine triphosphate (ATP) binding region of HSP90 is currently under a great degree of study because of the interest of its role in cancer and protein maintenance; the binding of ATP to HSP90 induces a large conformational change in the protein as a result of the activity of different types of stressors within the cells. In the present paper, a simple microfluidic biosensor is proposed for the characterization of ATP-HSP90 interactions through the principle of bioresistive variation. The experimental results prove that the present biosensor system is highly suitable for the detection of heat shock proteins present in a real-time biological sample, which is very useful for in-situ biomedical applications and rapid pathogenic detections. 相似文献
8.
The open source software (OSS) movement thrives on innovation and volunteer effort of developers. Scholars have expressed widespread concern about the sustainability of the OSS movement due to high levels of volunteerism. In this paper, we address a central challenge to the sustainability of OSS-developers’ acceptance of monetary rewards. We strive to explain why some OSS developers accept monetary rewards and others do not. Viewed through the theoretical lens of the private-collective innovation model (0395 and 0400), this allows us to describe when developers will accept private financial rewards. Our main research objective is to clearly map the web of relationships between causal antecedents, and developers’ acceptance behavior. Using a unique dataset that combines survey and behavioral measures, we find that – (a) intention to accept monetary rewards mediates the impact of motivational elements on developers’ acceptance of monetary rewards; (b) intrinsic and extrinsic motivations positively affect their intention to accept monetary rewards, community motivation negatively impacts intention and ideological motivation does not affect the intention to accept rewards and (c) these effects are obtained even after inclusion of several control variables. The theoretical and managerial implications of our work are described. 相似文献
9.
Ravichandran M. Regunathan J. Narayanan R. B. Kunthala Jayaraman Kaliraj P. 《Indian journal of clinical biochemistry : IJCB》1997,12(1):27-31
Human lymphatic filariasis is a chronic helminth infection caused byWuchereria bancrofti andBrugia malayi. Wide spectrum of clinical manifestations are seen in different clinical groups of filariasis patients which comprises asymptomatic patients with circulating microfilaria (MF), individuals with chronic lymphatic obstruction (CP), Endemic normals (EN) who are asymptomatic and amicrofilaraemic or the relatively rare tropical pulmonary eosinophilia (TPE). The cellular immune response to this infection varies in different clinical groups of filarial patients. ranging from normal lymphocyte proliferative response in EN individuals to lymphocyte hyporesponsiveness in MF to total parasite antigen [Brugia malayi antigen (BMA)]. But in response to recombinant filarial antigen (pRJ51) the lymphocyte proliferation is restored in MF patients. Interestingly the lymphocytes from MFs responded normally to parasite antigen when EN serum was added in the culture whereas sera from MFs failed to revert the lymphocyte hyporesponsiveness. In order to study the molecular mechanisms responsible for parasite antigen specific lymphocyte hyporesponsiveness, we analysed both the Th1 and Th2 type cytokine gene expression profile in different clinical groups of filarasis patients. MF individuals expressed elevated Th2 type cytokines like IL-4, IL-5 and IL-10 and decreased levels of IL-2 and IFN-γ in response to parasite antigen. Chronic patients have elevated levels of both Th1 and Th2 type cytokines in response to parasite antigen. The EN individuals had a purely Th1 type pattern with absence of IL-4 and IL-5 expression. These studies clearly demonstrate the role of Th2 cytokine like IL-10 in antigen specific hyporesponsiveness seen in MF patients. Any methods to arrest the progression of this disease should concentrate on the means to revert the Th2 type into Th1 type response in the MF patients either by Th1 type cytokine therapy or by using recombinant filarial antigen which stimulates the Th1 response. Further the recombinant filarial antigen which induces Th1 type cytokine response could be used for immunoprophylactic studies. 相似文献