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Seema Bhargava Meghaa Shanta Bhargava Eishaan Kamta Bhargava LM Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(2):148-151
Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented. 相似文献
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OBJECTIVE: The purpose of this retrospective study was to examine the epidemiology of child sexual abuse (CSA) among women in a poor, rural community in El Salvador, which was recovering from a 12-year civil war. METHODS: A cross-sectional, door-to-door survey was administered to 83 women. The LA Times Sexual Abuse Survey was used to determine the prevalence of CSA. The Hopkins Symptom Checklist (HCL) was used to measure long-term psychological sequelae of abuse (somatization, anxiety, depression, interpersonal sensitivity, and obsessive-compulsive traits). Information also was obtained about participation and number of relatives killed in the country's 12-year civil war. RESULTS: Of the 83 women interviewed, 14 (17%) reported a total of 21 experiences of CSA. The median age of abuse was 14 years. The majority of perpetrators (90.4%) were strangers, friends, or neighbors. None was a parent. The only significant difference between abused and non-abused women was on the depression measure, where abused women showed more pathology. After controlling for the number of relatives killed in the war, however, that difference failed to reach statistical significance. CONCLUSIONS: Differences in the epidemiology of CSA from that of other countries may be secondary to a different social structure in the rural Salvadoran community and non-disclosure by the women surveyed. The lack of difference in psychological symptoms between abused and non-abused women may be related to the different characteristics of the abuse and perpetrators. It also may be secondary to adverse social conditions such as poverty and war, which could obscure the long-term effects of CSA. 相似文献
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Brooke Klingberg J. J. A. A. M. Hoeboer Natasha Schranz LM Barnett Sanne I. De Vries 《Journal of sports sciences》2019,37(13):1534-1542
Failure to master age-appropriate fundamental movement skills (FMS) at a young age can limit motor skill competence affecting health. Assessments often have issues with feasibility and implementation in a field setting. As such, the purpose of this study was to investigate the validity and feasibility of the Athletic Skills Track (AST), in a pre-school setting. For the validation study sixty-five 3–6 year old children (25 boys and 40 girls) from five pre-schools across Adelaide, Australia participated. Correlations and linear regression analysis (adjusted for age and gender) were used to investigate the association between the time to complete the AST and the raw score of the Test of Gross Motor Development 2 (TGMD-2). For the feasibility study pre-school staff completed a semi-structured interview regarding the feasibility of the AST. The AST took less than a minute per child and the TGMD-2 around 20 minutes for two children. There was a strong negative correlation (r = ?0.63, p < 0.01) between the AST scores and the TGMD-2 scores. All five staff reported strengths of the AST to be its short administration time, setup and appropriateness. These results suggest that the AST could be a feasible and valid method of FMS assessment in Australian pre-schools. 相似文献
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