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Seema Bhargava Annsh Bhandari Sangeeta Choudhury 《Indian journal of clinical biochemistry : IJCB》2018,33(1):16-20
A high circulating concentration of the non proteinogenic amino acid homocysteine has been implicated as a risk factor for Alzheimer’s Disease and its prodromal stage, mild cognitive impairement. Furthermore, hyperhomocysteinaemia has been directly attributed to a deficiency in vitamins B12, folate, and B6. Several studies have demonstrated decrease in progression of mild cognitive impairement to Alzheimer’s Disease, and some have even shown an improvement in cognition after vitamin supplements with B12 and folate. Plausible mechanisms linking hyperhomocysteinaemia to Alzheimer’s and cognitive impairement have been hypothesized and demonstrated in hyperhomocysteinemic mice models. However, some studies have not elucidated any benefit of vitamin supplements in subjects with cognitive impairment. Hence, multicentric clinical studies need to be conducted to substantiate the mechanisms of neuronal degeneration due to hyperhomocysteinaemia and to demonstrate the beneficial effect of folate, B6 and B12 supplements on cognition. 相似文献
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ABSTRACT: A simple laboratory experiment, based on the Maillard reaction, served as a project in Introductory Statistics for undergraduates in Food Science and Technology. By using the principles of randomization and replication and reflecting on the sources of variation in the experimental data, students reinforced the statistical concepts and techniques introduced to them in lectures before the experiment. The experiment was run simultaneously by several student groups, using the same materials. Comparing the results of their analyses of variance, students became aware of the difference between P values and significance levels in making statistical decisions. In the experiment, the complete randomized design was applied; however, it is easy to adjust the experiment to teach students simple regression and randomized block designs. 相似文献
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Conclusion The second phase of education for a sustainable future (the widespread reorientation of educational practices, systems and
structures) is not yet widespread in the Asia-Pacific region. This is a very large undertaking and one that the economically
wealthy regions of the world have yet to make. Therefore it is not surprising that one of the world's economically poorer
regions has yet to enact such reforms. However, there is sufficient leadership in the region (in the form of international
and regional agencies and active NGOs) to indicate that if Member States can be convinced that a whole-of-government approach
to sustainable development is desirable, the teacher educators, curriculum development officials and teachers of the region
will have the requisite support to make the necessary reforms.
Original language: English
John Fien (Australia) Director of the Centre for Innovation and Research in Environmental Education, Griffith University. Teaching and research
interests focus on the reorientation of education towards sustainability in the formal school sector, teacher education and
community education. He is the author ofEnvironmental education: a pathway to sustainability and education for the environment andCritical curriculum theorising and environmental education. Editor of several UNESCO project publications, includingTeaching for a sustainable world (1995),Learning for a sustainable environment (1997) andTeaching and learning for a sustainable future (2000).
Osamu Abe (Japan) Professor in Education at Saitama University in Japan and the Project Leader of the Environmental Education Project of the
Institute for Global Environmental Strategies. A leading authority on conservation education and a well-known figure in both
the environmental NGO and environmental education movements in Japan.
Bishnu Bhandari (Nepal) Senior Research Fellow in the Environmental Education Project of the Institute for Global Environmental Strategies in Japan.
Former Director of the International Union for the Conservation of Nature's conservation programme in Nepal. With Osamu Abe,
he has convened a series of international conferences on environmental education in the Asia-Pacific region. They have publishedAn overview of environmental education in the Asia and Pacific region (1999) andA regional strategy on environmental education in Asia-Pacific (1999). 相似文献
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B. C. Harinath M. V. R. Reddy B. Bhunia Y. P. Bhandari V. K. Mehta P. Chaturvedi N. C. Prajapati R. K. C. Gupta 《Indian journal of clinical biochemistry : IJCB》2000,15(1):118-126
Lymphatic filariasis is a major public health problem in India with 412 million people living in bancroftian endemic areas and is a major cause of clinical morbidity. Twenty million people are reported to suffer from chronic disease manifestations such as lymphoedema, hydrocele or elephantiasis. At least twice the number have been shown to suffer from acute and occult filarial infections in an endemic area without diagnosis. Due to non-availability of suitable diagnostic test for confirming filaria aetiology other than parasitological examination, no significant study on filariasis in children has been reported earlier. Studies in our laboratory for more than a decade showed usefulness of microfilarial excretory-secretory antigen in confirming filarial aetiology in acute and occult infections in adults as well as in children. This study reports acute and atypical manifestations such as lymphadenopathy, asthmatic bronchitis, pulmonary eosinophilia, mono-arthritis, recurrent URI, pneumonia, nutritional anemia, pain in abdomen etc. in children living in filaria endemic area having no microfilaraemia but showing filaria aetiology by immunomonitoring for the presence of antibody or antigen and responding to optimal DEC therapy. 相似文献
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Brain type natriuretic peptide (BNP)—A marker of new millennium in diagnosis of congestive heart failure 总被引：1，自引：0，他引：1
Arun Raizada Suman Bhandari Muzaiyan Ahmed Khan Harsh Vardhan Singh Sherin Thomas Vikram Sarabhai Neelima Singh Naresh Trehan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):4-9
The burden of disease in patients with congestive heart failure is high. The future of BNP looks promising as it may be a
better diagnostic tool for the diagnosis of CHF in developing countries in new millennium. Natriuretic peptide hormones, a
family of vasoactive peptides with many favourable physiological properties, have emerged as important contenders for development
of diagnostic tools and therapeutic agents in cardiovascular disease. Measurement of B-type natriuretic peptide has become
as an easy-to-perform bedside test. The clinical and diagnostic significance of the measurement of plasma Nt-proBNP in the
diseases of the cardiovascular system with particular emphasis on the assessment of patients with heart failure and their
effects on predicting survival rate. The plasma levels of Nt-proBrain Natriuretic peptide responds more vigorously after myocardial
infarction than those of other natriuretic peptides. This article is an attempt to give a short overview on the utility of
BNP-blood levels for the diagnosis and treatment of heart failure 相似文献
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Anooj Bhandari 《Teaching Artist Journal》2018,16(3-4):100-105
ABSTRACTThe interruption of the school-to-prison pipeline has had a greater presence in many educational policies across the nation, many of these outlining Restorative Justice as a step toward the deconstruction of that system. In looking at policy asks, a question comes up as to how a culture change can be funded that can allow restorative practices to thrive in communities. The practice of storytelling sets valuable foundations for how restorative practices can thrive in groups on a microlevel while moving communities at-large toward potentials of social transformation. By examining transformational justice and the deconstruction of anti-Blackness in communities, best practices that form storytelling development, and their relationship to the current state of identity politics, we can find new ways to see restorative practices and their ability to grow within communities. 相似文献
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Abstract This paper aims to examine the strategies, mechanisms and practices of local level water use negotiation. The paper reveals that local people have their own strategies, mechanisms and approaches to utilise available limited natural resources. The case of water‐use negotiation was studied using direct observation, group discussion and interview methods. The paper explores the effect of norms, values, beliefs, knowledge, power, communication and facilitation, feelings of ownership on resources use negotiation and water‐resource management processes in Nepal. Women are the crucial actors and dynamic negotiators of community level resource use conflict. The role of development organisations is identified as facilitators to resolve conflict instead of leading the negotiation. The dominant extension approach in Nepal is not able to address resource use conflict. It needs an approach that acknowledges conflict as a part of social process and that promotes the facilitation of negotiation and adaptation. 相似文献
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Education and Information Technologies - We introduce two new software tools, Bongojontro and Bongojontro Baksobandi, aimed at reducing the barriers to programming for native speakers of Bengali,... 相似文献
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Manisha Mavai Yogendra Raj Singh R. C. Gupta Sandeep K. Mathur Bharti Bhandari 《Indian journal of clinical biochemistry : IJCB》2018,33(2):222-228
Autonomic activity may be deranged in thyroid dysfunctions and may lead to cardiovascular morbidity and mortality. Myopathy is a common manifestation in thyroid disorders and may be associated with raised serum creatine kinase (CK). We hypothesized that cardiovascular abnormality in thyroid dysfunction may manifest as raised CK-MB. This study was designed to investigate the correlation of CK and its isoform CK-MB with thyroid profile and linear parameters of heart rate variability (HRV). The study was conducted on 35 hypothyroid and hyperthyroid patients each, and 25 age-matched healthy controls. Autonomic activity was assessed by simple short term 5-min HRV. Biochemical evaluation of serum thyroid profile, CK-NAC and CK-MB were estimated in all the subjects. Our results demonstrated low HRV in hypo- as well as hyperthyroid patients. We observed significantly higher serum CK levels in hypothyroid patients when compared to hyperthyroids and controls. However, no significant differences were observed in CK-MB levels in the three groups. Significant positive correlation of CK with TSH and negative correlation with some HRV parameters (LF power, HF power, total power, SDNN, RMSSD) was observed in hypothyroid patients. Whereas correlation of CK-MB with thyroid profile as well as HRV parameters was non-significant in all the groups. Based on the CK and CK-MB findings and their correlation, we conclude that the cardiovascular changes seen in thyroid dysfunctions may primarily be due to autonomic imbalance without apparent cardiac muscle involvement. Whereas, raised CK levels indicate predominantly skeletal muscle involvement in hypothyroid patients. 相似文献
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