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Seema Bhargava Meghaa Shanta Bhargava Eishaan Kamta Bhargava LM Srivastava 《Indian journal of clinical biochemistry : IJCB》2016,31(2):148-151
Hyperhomocysteinemia (HHCY) has been demonstrated to affect cochlear microvasculature as well as cochlear epithelial cells directly, with a resultant alteration of the expression of matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). Hence, ascertaining the optimum concentration of MMPs and TIMPs in the cochlea could help to inhibit hearing loss due to HHCY by the administration of appropriate MMP inhibitors, Since infections/inflammations as well as ototoxic antibiotics have a similar mechanism of otic pathology, the cochlear damage they cause could also be similarly prevented. 相似文献
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We formulate a distinctly 'political liberal' conception of mutual respect, which we call 'civic respect', appropriate for governing the public political relations of citizens in pluralist democratic societies. A political liberal account of education should aim at ensuring that students, as future citizens, learn to interact with other citizens on the basis of civic respect. While children should be required to attend educational institutions that will inculcate in them the skills and concepts necessary for them to be free and equal citizens, parents should be granted as much freedom as is compatible with the requirements of civic respect to raise their children in accordance with their respective 'comprehensive doctrines' (systems of beliefs and values, including religious doctrines). We consider an objection to our position drawn from the account of upbringing recently advanced by Matthew Clayton, namely, that the conception of civic respect that we advance rests on an implausible view about the limited scope of the requirements of political justice. We develop an account of the 'basic structure of society' as the appropriate subject of political justice that can overcome this objection. 相似文献
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Thomas?M.?CreaEmail author Antonia?Eliana?Diaz-Valdes Elizabeth?Gruenfeld José?Acevedo Blain?Cerney Marlon?Medina Glenda?Hernandez Olga?Canelas 《Prospects》2017,47(3):245-256
School feeding programs in low- and middle-income countries tend to focus on school attendance and literacy. Some evidence suggests that bolstering schools as a nexus of community plays an important psychosocial function for children and families. This study examines the extent to which childhood literacy rates are associated with parents’ and teachers’ perceptions of community violence and cohesion, following participation in a large-scale school feeding program in the Department of Intibucá, Honduras. Primary school children (n = 3,147) from 176 schools completed standardized literacy tests. Scores were linked to parents’ (n = 328) and teachers’ (n = 537) responses about community cohesion and violence. Social bonding among parents was positively associated with children’s literacy. Community violence reported by teachers exerted a negative influence. The authors discuss these results in light of how vertically focused interventions such as school feeding can be integrated to account for the specific contextual factors that affect, and are affected by, the program itself. 相似文献
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Diane Pruneau Jackie Kerry Sylvie Blain Evgueni Evichnevetski Paul Deguire Pierre-Yves Barbier 《The Journal of environmental education》2013,44(4):217-231
Since coastal communities are already subjected to the impacts of climate change, adaptation has become a necessity. This article presents competencies demonstrated by Canadian municipal employees during an adaptation process to sea level rise. To adapt, the participants demonstrated the following competencies: problem solving (highlighting components of the problem and identifying constraints), futures thinking, risk prediction, vulnerability analysis, local knowledge, planning, and communication. However, some competencies that could be potentially useful in adaptation were used less frequently by participants: developing solutions, knowledge of adaptation, math skills, hope, and self-efficacy. 相似文献
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Brooke Klingberg J. J. A. A. M. Hoeboer Natasha Schranz LM Barnett Sanne I. De Vries 《Journal of sports sciences》2019,37(13):1534-1542
Failure to master age-appropriate fundamental movement skills (FMS) at a young age can limit motor skill competence affecting health. Assessments often have issues with feasibility and implementation in a field setting. As such, the purpose of this study was to investigate the validity and feasibility of the Athletic Skills Track (AST), in a pre-school setting. For the validation study sixty-five 3–6 year old children (25 boys and 40 girls) from five pre-schools across Adelaide, Australia participated. Correlations and linear regression analysis (adjusted for age and gender) were used to investigate the association between the time to complete the AST and the raw score of the Test of Gross Motor Development 2 (TGMD-2). For the feasibility study pre-school staff completed a semi-structured interview regarding the feasibility of the AST. The AST took less than a minute per child and the TGMD-2 around 20 minutes for two children. There was a strong negative correlation (r = ?0.63, p < 0.01) between the AST scores and the TGMD-2 scores. All five staff reported strengths of the AST to be its short administration time, setup and appropriateness. These results suggest that the AST could be a feasible and valid method of FMS assessment in Australian pre-schools. 相似文献
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Increased emphasis on celebrity, and the growing cultural importance of the Internet, help drive continuing anxiety about the influence of the media on the young. Though recent empirical studies of celebrity and media influence on adolescents have produced mixed findings, there has been a tendency by researchers to test for celebrity and media influence on samples in a manner which precludes juxtaposing these influences with those produced by family, peer group, school, or within other ‘local’ contexts. The media themselves continue to raise alarm about the impact of the Internet. An exploratory investigation was made of Scottish adolescents’ media choices, using a widespread questionnaire‐based survey of 427 secondary year‐two pupils (13‐ to 14‐year‐olds) in 2002. This was a ‘scoping’ study which will lead to further qualitative research, but it did produce evidence that parental and school influences remain strong. The influence of media personalities is visible in the responses but is comparatively weak. There is no evidence in the choices reported by the informants, in any of the media considered, of the salience of violence or sexuality. Much more common is interest in humour, in human relationships and personal drama, in sport and in science fantasy. The study notes in passing evidence of local cultural strengths and also considerable diversity, along with American and other global influences. 相似文献
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