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Praveen Sharma P. K. Sharma D.Sc. J. Pramod L. K. Kothari Rashmi Ranka Sushma Sharma 《Indian journal of clinical biochemistry : IJCB》1989,4(1):62-64
Sixteen weeks of chronic vitamin C deficiency, induced in guinea pigs by restricted vitamin C intake, resulted in a marked
increase in the serum total LDL- and VLDL- cholesterol, triglycerides and total lipids. HDL-cholesterol decreased resulting
in a highly significant increase in LDL/HDL ratio. The results reconfirm that vitamin C deficiency causes changes in blood
lipid profile which could promote atherogenesis. 相似文献
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Garima Mehta Seema Kothari P. P. Singh 《Indian journal of clinical biochemistry : IJCB》2001,16(1):65-71
From January 1992-January 1998, 1404 patients attended the “Breast Clinic” of R.N.T. Medical College M.B. Hospital, Udaipur.
Out of these, 11% and 81% patients had breast cancer (B.C.) and benign breast cancer (B.B.D.) respectively. The oxidative
load in B.C. was 2.32 times higher than controls, but comparable to B.B.D. β-Carotene deficiency was uncommon in patients,
whereas vitamin A deficiency was almost equally common in both B.C. and controls. Most of the patients had almost depleted
levels of α-tocopherol and ascorbic acid but their TBAR levels were in normal range. The data in the present study when compared
with B.B.D. and other local normal subjects point out: a) oxidative burden in B.C. is a consequence and not the cause of the
disease, (b) oxidative stress could be one of the etiological factors in tumor expression, which need not to be malignant
and c) α-tocopherol and ascorbic acid are not importantly responsible for higher oxidative burden in B.C. 相似文献
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Michelle D. Lazarus Gordon L. Kauffman Jr. Milind J. Kothari Timothy J. Mosher Matthew L. Silvis John R. Wawrzyniak Daniel T. Anderson Kevin P. Black 《Anatomical sciences education》2014,7(5):379-388
Current undergraduate medical school curricular trends focus on both vertical integration of clinical knowledge into the traditionally basic science‐dedicated curricula and increasing basic science education in the clinical years. This latter type of integration is more difficult and less reported on than the former. Here, we present an outline of a course wherein the primary learning and teaching objective is to integrate basic science anatomy knowledge with clinical education. The course was developed through collaboration by a multi‐specialist course development team (composed of both basic scientists and physicians) and was founded in current adult learning theories. The course was designed to be widely applicable to multiple future specialties, using current published reports regarding the topics and clinical care areas relying heavily on anatomical knowledge regardless of specialist focus. To this end, the course focuses on the role of anatomy in the diagnosis and treatment of frequently encountered musculoskeletal conditions. Our iterative implementation and action research approach to this course development has yielded a curricular template for anatomy integration into clinical years. Key components for successful implementation of these types of courses, including content topic sequence, the faculty development team, learning approaches, and hidden curricula, were developed. We also report preliminary feedback from course stakeholders and lessons learned through the process. The purpose of this report is to enhance the current literature regarding basic science integration in the clinical years of medical school. Anat Sci Educ 7: 379–388. © 2014 American Association of Anatomists. 相似文献
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Amita Chudgar Karyn Miller Brij Kothari 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2012,58(1):73-89
Household engagement in a child??s education is a complex process; depending on the culture and the context, it may be revealed through a variety of behaviours. Using data from one district in rural Gujarat, India, four indicators of a household??s educational engagement were employed to investigate the relationship between household literacy levels and the household??s engagement in the education of its child members. The findings on educational engagement were also compared across households with different wealth and income levels. Uniformly, indicators of household literacy levels were found to be more important in understanding a household??s educational engagement than a household??s wealth and income levels. 相似文献
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Beth L. Green Anna M. Malsch Brianne Hood Kothari Jessica Busse Eileen Brennan 《Early Childhood Education Journal》2012,40(2):123-132
This article describes the development, implementation, and outcomes of a pilot intervention designed to enhance preschool
programs’ ability to support children’s social-emotional development. Working with two Head Start programs, the intervention
included (1) restructuring existing early childhood mental health consultation services; (2) engaging programs in a mental
health-specific strategic planning; (3) providing training to program staff in early childhood mental health best practices;
and (4) implementing staff wellness activities to promote a healthy organizational culture. Research Findings: Results from
quantitative staff surveys found significant improvement over time in terms of reduced staff stress, increased levels of understanding
of best practices in early childhood mental health, and more evidence of a shared understanding of how best to meet children’s
mental health needs. Results were strongest for management and teaching staff, compared to other staff types. Practice Implications:
Head Start and preschool programs may benefit from institutionalizing strategies to ensure that continued attention is paid
to their program’s mental health services through ongoing strategic planning, supporting staff wellness, and by effective
use of mental health consultants. Mental health consultants may be most valuable when they focus on capacity-building activities
such as staff coaching and training, and working with management teams to ensure a collective “mental health perspective”. 相似文献
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Brij Kothari Joe Takeda Ashok Joshi Avinash Pandey 《International Journal of Lifelong Education》2013,32(1):55-66
Same language subtitling (SLS) refers to the idea of subtitling motion media programmes (television and film) in the ‘same’ language as the audio. This simplest of additions in existing television programmes, especially film songs and music videos, can make a quantum contribution to the improvement of reading skills of over 325 million neo-literate people in India. Song videos are watched with great passion all over India, in every state and major language. Earlier work on SLS reported that it was found to enhance the entertainment value of televised songs for both literate and neo-literate viewers. This paper discusses a controlled experiment to ‘measure’ the impact of SLS on the reading skills of disadvantaged school children. The results confirm that SLS of film songs leads to reading skill improvement, thus reaffirming the enormous potential of this simple and economical approach for mass literacy skill development in India. 相似文献
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Brij Kothari P. G. Vijaya Sherry Chand Rajeev Sharma Amar H. Kalro Parvinder Gupta 《International Journal of Lifelong Education》2013,32(5):407-417
The Shiksha Karmi Project in Rajasthan, one of the most educationally challenged states, is at the frontiers of alternative models of primary education in India. The key ideas underlying this model are: (i) the taking over of ‘sick’ schools in remote regions of the state and turning them around, (ii) creating new schools driven by demand from the ground, (iii) human resource investments to train local village teachers, (iv) strong linkages between the school and the community built upon a spirit of voluntarism, (v) an explicit movement toward gender equity and (vi) a bold attempt at the universalization of primary education through a combination of formal and non-formal institutions. This article provides a grounded feel for the Shiksha Karmi Project in a stellar school, Meena Dant Ka Pura. While the case highlights the shortage of locally based female teachers in the entire Shiksha Karmi Project, it also suggests the very real possibility of employing Shiksha Karmi Project alumni and higher grade students in teaching roles. Overall, primary education in India has much to learn from the Shiksha Karmi Project experience. 相似文献
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Sweta T. Kothari Ranjana A. Deshmukh 《Indian journal of clinical biochemistry : IJCB》2006,21(1):15-26
Cytokines, viral load and opportunistic infections play an important role in HIV-disease progression. Hundred children vertically
infected with HIV were enrolled to determine mRNA levels of TNF-α, IL-10, IL-4 and IFN-γ. These levels were estimated by amplifying
cytokine mRNA from peripheral blood mononuclear cells. Severity of HIV was staged by the reduction in CD4
+ T cells and the onset of opportunistic infections. IL-10 mRNA levels were observed to increase with the severity. Despite
the rising IL-10 mRNA levels, TNF-α mRNA levels increased with severity of HIV and decrease in CD4
+ T cell counts. IL-4 mRNA levels increased with the reduction in CD4
+ T cell numbers. Depleting mRNA levels of IFN-γ contributed to the worsening of HIV disease. Increase in TNF-α and IL-4 levels
appended to the disease severity by upregulation of the viral replication. Increased IL-10 levels and decreased IFN-γ levels
predisposed the children to HIV associated opportunistic infections, which in return contributed to cytokine disarray. 相似文献