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1.
Rukmini M. S. Benedicta D'Souza Vivian D'Souza 《Indian journal of clinical biochemistry : IJCB》2004,19(2):114-118
Free radical mediated pathological processes may have a role in schizophrenia. Free radicals (oxy radicals, such as superoxide,
hydroxyl ions and nitric oxide) cause cell injury, when they are generated in excess or when the antioxidant defense is impaired.
Both these processes seem to be affected in schizophrenia. In this study we investigated erythrocyte superoxide dismutase
(SOD) and catalase (CAT) activities as antioxidant enzymes, malondialdehyde (MDA) as a sign of lipid peroxidation in schizophrenic
patients. Activities of superoxide dismutase, catalase and malondialdehyde were greater in patients compared with the control
group which may reflect increased oxidative stress in the brain tissue of schizophrenics. In the patient group erythrocyte
SOD and CAT activities were weakly negative correlated with MDA concentration. These data reveal that antioxidant defense
mechanisms might be impaired in schizophrenic patients. These findings also provide a theoretical basis for the development
of novel therapeutic strategies, such as antioxidant supplementation. 相似文献
2.
Studies on serum arginase have shown that it is having the least unexplained variation and its activity is closely related with the severity of jaundice. Arginase is thus stable, consistent, efficient, specific and sensitive to changes. It is a better indicator of hepatocellular damage. 相似文献
3.
Herman S D'Souza Geraldine Menezes T Venkatesh 《Indian journal of clinical biochemistry : IJCB》2002,17(1):1-4
Our study aimed at comparing lead and zinc protoporphyrin (ZPP) levels in capillary and venous blood samples in a small population
and to employ an easier method of sample collection for a major screening program in school children in major Indian cities.
An awareness program on lead and its effects was conducted in two different schools. A total of thirty urban school children
from South India, with an age group between 4–12 years consented for dual blood sampling and reported for the study. Venous
and capillary blood samples were obtained simultaneously. Blood lead and zinc protoporphyrin (ZPP) levels were estimated using
ESA Lead Analyzer and Haematofluorometer respectively. A significant correlation between capillary and venous ZPP (r=0.98)
and lead (r=0.99) was observed. Rank sum test showed that there is no statistically significant difference between capillary
and venous ZPP (P=0.891) and lead (P=0.672) values. This pilot study recommends that screening for lead may be done using
capillary blood samples since significant correlation is observed between capillary and venous blood measurements. Obtaining
samples using this mode is a non-invasive, less expensive, quick and easy method in children. Appropriately performed capillary
sampling may be considered as an acceptable alternative to venipuncture for screening of blood for lead poisoning both in
children and adults. 相似文献
4.
5.
Souvik Ghosh H.N. Verma Dinesh Chandra P. Nanda 《The Journal of Agricultural Education and Extension》2013,19(1-4):17-26
The key to agricultural development in the eastern region of India, where problems of excess water and water scarcity coexist, is the scientific management of water resources with the adoption of recommended water-management technologies. A vast networking of infrastructure for the development and dissemination of water- management technologies have been designed since the very inception of planned economic change. Despite these concerted efforts, a large number of recommended technologies are either being adopted in piece-meal or not at all. The research and extension systems have been generating and disseminating technologies, therefore, it was felt worthwhile to assess the feasibility and appropriateness of recommended tecnologies as perceived in the first instance by the personnel of the research system and followed by the extension personnel. These steps were felt to be a precursor to screen the recommended technologies for their dissemination and evaluation in different farming systems. The assessment of recommended water-management technologies was performed after their documentation from different organisations working in the field of water management in two eastern India states viz. Orissa and West Bengal. The perception of 30 personnel members of the research system regarding the feasibility of these technologies elucidated that out of 86 documented recommended water-management technologies, 40 were having feasibility scores of ≥ 4.0; 8 technologies with score £ 3.0 and the rest of the 38 technologies with a score between 3.0 and 4.0 on a feasibility continuum range from 1.0 (not feasible) to 5.0 (highly feasible). Out of 40 recommended technologies (already assessed as highly feasible by the research personnel), extension personnel have perceived 16 and 10 technologies as highly appropriate and feasible, respectively. While six and four technologies were found to be less appropriate and feasible, respectively. Correlation of all nine indicators of appropriateness with feasibility of technologies was significant. Five indicators of appropriateness viz. simplicity, physical compatibility, production sustainability, cultural compatibility and cost together constituted 36.8 per cent of the total variation in feasibility with the ‘t’ values and ‘F’ values being significant. It indicates that not appropriateness of technologies alone but other factors influence the feasibility of technologies. 相似文献
6.
The high mobility group (HMG) proteins I and Y are well characterised non-histone chromosomal proteins which bind to A-T rich
regions of DNA and regulate gene expression and/or DNA replication. A correlation has been demonstrated between the increased
expression of HMG-Y proteins and malignancy. However, it is not known whether the expression of HMGs particularly, the Y group,
is a function of proliferation rate. In the present study, we have used normal tissues of calf testes, thymus and liver. The
results show distinctly high expression of HMG-Y proteins in testes than in thymus and the expression was practically undetectable
in liver. The results suggest that even in normal tissues there is a direct correlation between the proliferation rate and
the expression of the HMG-Y proteins, which can partly explain its increased expression in cancer. 相似文献
7.
8.
Karen M. D'Souza Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2007,22(1):37-44
This study was aimed at isolating, in its pure form, and characterizing the sarcoplasmic reticulum from caprine (Capra hircus) heart. The sarcoplasmic reticulum from thirty caprine heart ventricular homogenates was isolated and purified. It was characterized
on the basis of both, its protein and lipid composition. The protein content was 142±10 mg/g of tissue. Ca2+-ATPase activity equaled 3.75±1.06mmol Pi/mg protein/min while the uptake rate was 24±1.14 nmol/mg protein/min. 205kD, 110kD,
90kD, 84kD, 66kD, 55kD and 29kD molecular weight proteins were seen on an SDS polyacrylamide gel. Triglyceride, Cholesterol
and Phospholipids (phosphatidylethanolamine, phosphatidylinositol, phosphatidylcholine, sphingomyelin and phosphatidylserine)
were present in increasing order of their concentration. Long chain fatty acids predominated over the unsaturated ones. The
ryanodine receptor displayed two binding sites for ryanodine. Characterisation encompassing the above biochemical aspects
of normal caprine cardiac sarcoplasmic reticulum was thus achieved after isolating it in the pure form. 相似文献
9.
Susceptibility of Schizophrenic patients to lipid peroxidation relative to healthy control subjects was investigated by measuring
the malondialdehyde (MDA) levels in plasma. The main finding was that Schizophrenic patients were more susceptible than control
subjects to oxidative damage as evident from increased MDA levels in plasma. Antioxidant levels are also depleted in Schizophrenic
patients when compared to normal subjects as evident from decreased levels of vitamins E and C in the plasma. Impaired antioxidant
defense and increased lipid peroxidation suggests that treatment with antioxidants (Vitamin E, Vitamin C, beta carotene) at
the initial stages of illness may prevent further oxidative injury and deterioration of associated neurological deficits in
Schizophrenia. 相似文献
10.
A. Supriya Simon D. Dinesh Roy V. Jayapal T. Vijayakumar 《Indian journal of clinical biochemistry : IJCB》2010,25(2):164-168
Cardiometabolic syndrome is one of the major public health issues of this century which describes a cluster of clinical characteristics.
Seventy two patients with coronary artery disease (CAD) and cardiometabolic syndrome and forty healthy age and sex matched
normal controls were selected for this study. Detailed clinical epidemiological and anthropometric characteristics were noted.
Lipid profile and Cytokinesis-block micronuclei (CBMN) assay using cytochalasin B were carried out in all the subjects. Serum
total cholesterol, triglyceride and LDL-cholesterol was significantly higher and HDL cholesterol was significantly lower in
patients compared to their normal counter-parts (P<0.05). CBMN frequency of the patients was significantly higher at all ages
compared to their normal counter parts (P<0.05). Various risk factors like diabetes, hypertension, dyslipidemia, abdominal
obesity, smoking and alcoholism were found influenced the CBMN frequency; but the changes were not significant. From this
study it can be concluded that DNA damage was found to be higher in patients with cardiometabolic syndrome which may be attributed
to the generation of free radicals associated with alcohol consumption, tobacco use, dyslipidemia and glucose intolerance
and the accumulation of free radicals with increase in age. 相似文献