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This study reports on the use of a microsystem for evaluation of photodynamic therapy (PDT) procedures on the "mixed" (carcinoma-normal) cultures. Balb/3T3 (normal mouse embryo) and A549 (human lung carcinoma) cells were tested in separated and "mixed" cultures. Interactions and migration of cells cultured together were observed. The PDT procedures were examined in the hybrid (PDMS/glass) microsystem which contains cell culture microchambers integrated with network of microchannels. We investigated that the number of dead cells after PDT procedures is dependent on the kind of cell culture. Moreover, the influence of the carcinoma cells on the viability of normal cells in the "mixed" culture was observed. 相似文献
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Elzbieta Jastrzebska Ilona Grabowska-Jadach Michal Chudy Artur Dybko Zbigniew Brzozka 《Biomicrofluidics》2012,6(4)
Cell migration is an important physiological process, which is involved in cancer metastasis. Therefore, the investigation of cell migration may lead to the development of novel therapeutic approaches. In this study, we have successfully developed a microsystem for culture of two cell types (non-malignant and carcinoma) and for analysis of cell migration dependence on distance between them. Finally, we studied quantitatively the influence of photodynamic therapy (PDT) procedures on the viability of pairs of non-malignant (MRC5 or Balb/3T3) and carcinoma (A549) cells coculture. The proposed geometry of the microsystem allowed for separate introduction of two cell lines and analysis of cells migration dependence on distance between the cells. We found that a length of connecting microchannel has an influence on cell migration and viability of non-malignant cells after PDT procedure. Summarizing, the developed microsystem can constitute a new tool for carrying out experiments, which offers a few functions: cell migration analysis, carcinoma and non-malignant cells coculture, and evaluation of PDT procedure in the various steps of cell migration. 相似文献
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Magdalena Elzbieta Wojcieszak 《Mass Communication and Society》2013,16(4):527-546
This study draws on survey data obtained from members in neo-Nazi discussion forums and builds on evidence that participation in these forums exacerbates false consensus, that is, overestimating public support for own views. This study goes further to test whether contacts with dissimilar offline social networks as well as exposure to ideologically dissimilar news media attenuate false consensus and its association with online participation. Contrary to predictions, politically dissimilar networks do not reduce false consensus among the analyzed sample. Exposure to ideologically dissimilar news media, on the other hand, results in more accurate estimates (main effect), but it exacerbates false consensus as resulting from participation in neo-Nazi online groups (interactive effect). Theoretical and practical implications are discussed. 相似文献
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Elisabeth Rudowicz 《Scandinavian Journal of Educational Research》2013,57(3):273-290
Different manifestations of the impact of culture on creativity are discussed and illustrated by empirical studies. They include: (i) conceptualisation of creativity on both the explicit and implicit levels; (ii) attitudes towards creativity and values attached to creativity; (iii) channelling creative endeavour through different domains of human activities; and (iv) socialisation processes and educational goals and practices. It is argued that creative expression is a universal human phenomenon that is firmly grounded in culture and has its own profound impact on culture itself. The effects of culture on creativity are presented within an interactive model that, besides culture, also incorporates historical, societal and individual factors. Methodological dilemmas involved in cross-cultural studies of creativity are also discussed. 相似文献
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Elzbieta Rudowicz Aleksandra Tokarz Andrzej Beauvale 《Thinking Skills and Creativity》2009,4(2):104-115
The social desirability of characteristics associated with creativity and cultural stereotypes was examined across Polish and Chinese cultures. Polish responses were compared with those from an earlier Chinese study (n = 451). First, we carried out an initial study among 116 Polish students to determine what traits are parts of the national stereotype. Then we sought answers from another set of Poles (n = 610) as to what traits were, first, creative and, secondly, desirable. To analyze the responses we first ranked the traits that both Polish and Chinese students found desirable and then compared the desirable traits across cultures with traits known to be trademarks of creativity. As expected, we found differences between the two samples arising from underlying social origins in that: (a) Poles desired more creative traits and more western traits, whereas Chinese desired more Confucianism based traits and less creative traits; and (b) both Poles and Chinese found creativity traits are desirable albeit Poles found them more desirable than Chinese. An interesting side note is that Poles, unlike Chinese, do not take a positive view of their cultural traits. 相似文献
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