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Lakshmi Lavanya Reddy Swarup A. V. Shah Alpa J. Dherai Chandrashekhar K. Ponde Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2016,31(1):87-92
Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP. 相似文献
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Ashavaid TF Raje HS Shah BV Shah SA 《Indian journal of clinical biochemistry : IJCB》2011,26(1):18-21
Single nucleotide polymorphisms in CYP3A5 (A6986G) and MDR-1 (C3435T) genes have been shown to be associated with the pharmacokinetics
of tacrolimus in case of renal transplant recipients. Knowing these genotypes of the recipients before undergoing transplantation,
is therefore essential for physicians to adjust the starting dose of tacrolimus in order to avoid drug induced nephrotoxicity.
We have designed an allele specific PCR method for easier and rapid detection of these polymorphisms. 20 Indian renal transplant
recipients on tacrolimus who developed nephrotoxicity within 1 month of transplantation and 58 Indian non-transplant subjects
having the risk factors for kidney disease i.e. hypertension or diabetes or the family history of these, have been studied
for these SNPs by allele specific PCR method. The data suggest that the heterozygosity of CYP3A5 and mutant allele frequency
of MDR-1 SNP is higher in transplant patients as well as in general population. 相似文献
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Ghanshyam Swarup 《Resonance》1998,3(10):70-78
Modification of proteins by phosphorylation is the major general mechanism by which many cellular functions in eukaryotic
cells such as cell division, malignant transformation, differentiation, signal transduction etc. are controlled by external
physiological stimuli. At the molecular level protein phosphorylation-dephosphorylation can alter various properties of the
substrate molecules such as enzymatic activity, sub-Cellular location, ligand binding, interaction with other proteins, DNA
binding and some other functional properties. The changes in molecular properties of proteins brought about by protein phosphorylation
play a critical role in regulating various cellular functions. 相似文献
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