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Hepatocellular carcinoma (HCC) is one of the commonest tumors worldwide. The treatment of HCC is vital for disease diagnosis and prognosis, as the liver is the most important organ controlling metabolic functions. Now-a-days, western folklore medicines are largely dependent on the phyto compounds which are highly effective in therapy and with low side effects. Luteolin is a flavonoid (3,4,5,7-Tetrahydro flavones) possess anti-inflammatory, anticancer and anti allergic property. The present study evaluates the efficacy of luteolin against N-nitrosodiethylamine (DEN) induced HCC in albino rats. In the highlight of the above, luteolin was evaluated for its efficacy against DEN induced HCC in male Wistar albino rats. The Biochemical parameters such as tissue damaging enzymes viz., AST, ALP, LDH and γ-GT, enzymatic antioxidants viz., SOD, CAT, GSH and GPx and histopathological changes have been estimated. The tissue damaging enzymes were found to be high in DEN alone treated group whereas the enzymatic antioxidants decreased destructively. Severe lesions and cirrhosis were observed in the toxin (DEN alone) treated group. The luteolin treated DEN group altered the tissue damaging enzymes and the enzymatic antioxidants. The damaged lesion in the histoarchitecture of DEN treated rat liver was almost completely restored. Finally this study strongly demonstrates that luteolin has potent curative property against HCC in albino rats. 相似文献
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P. Rani K. Meena Unni J. Karthikeyan 《Indian journal of clinical biochemistry : IJCB》2004,19(2):103-110
The present paper focuses on assessing the levels of various enzymatic and non-enzymatic antioxidants in selected berries
of Indian sub-continent viz., gooseberry, grapes, orange and tomato. This study has revealed that orange, tomato and grapes
possess predominant quantities of enzymatic antioxidants namely SOD, catalase and glutathione peroxidase respectively. The
levels of antioxidants analyzed namely reduced glutathione, vitamin C and vitamin A were maximal in grapes, orange and tomato
respectively. All the extracts of berries included in the present study inhibited iron inducedin vitro lipid peroxidation in erythrocytes, the extend of inhibition being highest for gooseberry and orange compared to tomato and
grapes which could be attributed to their in-built antioxidant system. 相似文献
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M. B. Karthikeyan 《Resonance》1996,1(6):69-76
This article presents an introduction to multimedia and describes one of its popular applications, video-on-demand. 相似文献
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K.S. Umapathy 《International Information and Library Review》2013,45(3):289-301
The ‘globalization’ phenomenon has infiltrated many societies and cultures, promoting the creation of ‘global villages’ where the risks of cultural levelling are evident. The Agence de la Francophonie (ACCT), secretariat of the Francophone Summits, has raised awareness about this issue, through information gathered by its Banque internationale d'information sur les États francophones (BIEF) programme. The last Francophone Summit (Cotonou, 1996) adopted a recommendation recognizing the global impact of the ‘information highway’ while urging the Francophonie to promote the cultural specificities and diversities of its Member States. The information and communication technologies and the information highway seem to favor the linguistic imperialism of certain societies and cultures. This trend triggers two types of reaction: (1) an accelerated merger of cultures into one single conventional universe and (2) an assertion of national cultural identities. The Francophonie has chosen the latter and has developed strategies to support its position. 相似文献
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In this paper sufficient conditions for the complete controllability of nonlinear stochastic integrodifferential system are established. The results are obtained by using the Banach fixed point theorem. An example is provided to illustrate the technique. 相似文献
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ABSTRACTBackground and Context: The use of block-based programming environments is purported to be a good way to gently introduce novice computer programmers to computer programming. A small, but growing body of research examines the differences between block-based and text-based programming environments.Objective: Thus, the purpose of this study was to examine the overall effect of block-based versus text-based programming environments on both cognitive and affective student learning outcomes.Method: Five academic databases were searched to identify literature meeting our inclusion criteria and resulted in 13 publications with 52 effect size comparisons on both cognitive and affective outcomes.Findings: We found small effect size (g = 0.245; p = .137; with a 95% confidence interval of ?0.078 to 0.567) in favor of block-based programming environments on cognitive outcomes, and a trivial effect size (g = 0.195, p = .429; with a 95% confidence interval of ?0.289 to 0.678) on affective outcomes. Both effect size calculations were statistically insignificant using random effects models. The effect sizes were examined for moderating effects by education level, learning environment, and study duration. Some evidence of publication bias was detected in these data.Implications: More research is needed to examine the utility and efficacy of block-based programming environments for novice programmers. Future studies should account for hybrid programming environments using novel research methods. 相似文献
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Karthikeyan B Jaleel CA Gopi R Deiveekasundaram M 《Journal of Zhejiang University. Science. B》2007,8(7):453-457
An experiment was conducted on Catharanthus roseus to study the effect of seed treatments with native diazotrophs on its seedling growth and antioxidant enzyme activities. The treatments had significant influence on various seedling parameters. There is no significant influence on dry matter production with the diazotrophs, Azospirillum and Azotobacter. However, the vital seedling parameters such as germination percentage and vigour index were improved. Azotobacter treatment influenced maximum of 50% germination, whereas Azospirillum and Azotobacter were on par with C. roseus with respect to their vigour index. There was significant difference in the population of total diazotrophs. Azospirillum and Azotobacter between rhizosphere and non-rhizosphere soils of C. roseus had the same trend and were observed at various locations of the study. The activities of antioxidant enzymes such as superoxide dismutase （SOD）, peroxidase （POX） and catalase （CAT） were increased to a significant extent due to the treatment with diazotrophs. 相似文献
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