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Harleen Mangat Tajamul Hussain C Sundaram MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(2):74-79
Poly A RNA status and itsin vitro translation in a rabbit reticulolysate cell free system, were assessed in the skeletal muscle of young boys with Duchenne
muscular dystrophy. Compared to normals there is a significant 48% increase in poly A RNA content of dystrophic muscle and
its translatability was increased by 56% based on35S methionine incorporation into total protein systhesised. Immunoprecipitation of the translated products with monospecific
antibodies showed that there is a 2.6 fold and a 2 fold increase in m and μ calpains respectively. This underlines the importance
of both synthetic and degenerative activities in the early pathology in DMD muscle. 相似文献
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Berman BA Eckhardt EA Kleiger HB Wong G Lipton DS Bastani R Barkin S 《American annals of the deaf》2000,145(3):245-255
Formidable barriers hinder use of standard data collection methods among deaf youth. Culturally and linguistically sensitive data collection strategies are needed to identify the unmet health and programming needs of this population. Unfortunately, researchers often fail to describe the issues involved in developing such targeted methods. The authors describe development of a culturally appropriate data collection instrument for a study of tobacco-related knowledge, attitudes, and practices among deaf youth. The instrument uses interactive multimedia technology to administer a questionnaire translated into the primary languages used by the Deaf. The procedures taken to accommodate this technology to these languages and to Deaf culture are described. This process yielded useful insights with respect to data collection not only among the Deaf, but among other frequently overlooked and underserved populations as well. 相似文献
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Edward D. Lipton 《Research quarterly for exercise and sport》2013,84(3):402-405
Abstract It was the purpose of this investigation to conduct a program in perceptual-motor development and to determine changes in, and assess relationships between, changes in perceptual-motor development on visual perception and reading readiness of first-grade children. Four classes were equated on the variables age, height, sex, and weight. Two of the classes (experimental) were exposed to the perceptual-motor program for 12 weeks and the other two classes (control) took part in the conventional physical education program. All students participated in their regular classroom activities. All subjects were evaluated in perceptual-motor development, visual perception, and reading readiness prior to and immediately following the research program. The difference scores (pre- and post-test) were evaluated by two-way ANOVA to determine if there were any significant differences between groups. F ratios for the three variables tested were all significant beyond the .01 level in support of the perceptual-motor program. 相似文献
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This paper argues that those seekingequity-focused educational reform have much tolearn from social movements and grassrootspolitical organizing. We explore how theknowledge, skills, strategies, and passionatenarratives emanating from suchnon-institutional change efforts can shed light onthe difficulty of equity-focused educationreform and provide equity reformers with anexpanded repertoire of change strategies. Wepursue our analysis using an ``exemplary' caseof reform at Wilson High School. The case datawere collected as part of a four-year study documenting the college preparation experienceof students of color in diverse, comprehensivehigh schools. We conclude that the logic andstrategies employed in social and politicalmovements – in contrast to those found inorganizational change models – are more likelyto expose, challenge, and if successful,disrupt the prevailing norms and politics ofschooling inequality that frustrateequity-focused reforms. Without attention tothese dynamics, such reforms are abandonedentirely or implemented in ways that actuallyreplicate (perhaps in a different guise) thestratified status quo. We also conclude thatthose of us whose research focuses on equityreforms would be well advised to use social andpolitical movements as lenses to more clearlyview the course of these much advocated, butseldom achieved efforts. 相似文献
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Five-year-old children categorized as skilled versus unskilled counters were given verbal estimation and number word comprehension tasks with numerosities 20-120. Skilled counters showed a linear relation between number words and nonsymbolic numerosities. Unskilled counters showed the same linear relation for smaller numbers to which they could count, but not for larger number words. Further tasks indicated that unskilled counters failed even to correctly order large number words differing by a 2 : 1 ratio, whereas they performed well on this task with smaller numbers, and performed well on a nonsymbolic ordering task with the same numerosities. These findings provide evidence that large, approximate numerosity representations become linked to number words around the time that children learn to count to those words reliably. 相似文献
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P. Aruna Prabhavathi Tajamul Hussain G. N. Mallikarjuna Rao MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(1):94-98
The efficacy of two intragenic polymorphic markers of factor VIII gene has been examined in Andhra Pradesh population with
a view to confirm/revise the strategy for carrier detection that would be precise and economical. The haemophilia A carrier
was detected using Bcl I and Xba I polymorphic sites in intron 18 and 22 respectively. The cumulative efficiency of these
two sites for detection of carriers is 100% since all 15 families tested were informative for one of these polymorphisms,
thus confirming their usefulness for factor VIII gene mutations found in Andhra Pradesh. 相似文献
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