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Muhammad Farooq Naseer Manasa Patnam Reehana R. Raza 《Economics of Education Review》2010,29(4):669-683
This paper evaluates the impact of teaching innovations, introduced in public primary schools under the Children Resources International (CRI) Program, on student outcomes. We estimate students’ learning based on their scores on standardized tests. We match schools and children within the treatment and comparison group and find that the CRI Program has been effective in raising learning achievement. Moreover, the results are robust to unobserved selection bias. The average gain for a CRI student represents an improvement of 0.40 standard deviations. The results stay unchanged when we use alternative estimators for the treatment effect including the bias-corrected estimator proposed by Abadie and Imbens (2006). 相似文献
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We report a case of a diabetic, heterozygote with near normal hematology, marginally low level of hemoglobin A2(HbA2) having an increased level of hemoglobin F(HbF) that was pancellularly distributed among the red cells. BioRad DiaSTAT measurements
gave a high glycated hemoglobin A1c(HbA1c) of 31.5% and the BioRad Variant analyzer recorded an HbA1c value which was very
low, in discordance with the detected blood glucose levels. Flow cytometry and polymerization chain reaction (PCR) based studies
were carried out which revealed the case to be that of the common hereditary persistence of fetal hemoglobin (HPFH)-3, an
Asian Indian mutation. Fructosamine estimation and HbA1c by Boronate affinity chromatography were able to resolve the discordant
value detected and was able to confirm the diabetes status. The case would have been a diagnostic dilemma, if reported without
correlation. 相似文献
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Murali Woodi Amit Kumar Mondal Balaram Padmanabhan Krishnaswamy Patnam Rajagopalan 《Indian journal of clinical biochemistry : IJCB》2009,24(1):23-29
Mass spectrometry provides a convenient platform for the study of different protein post translational modifications from
clinical specimen. Analysis of different post translational modifications of hemoglobin like glycation and glutathionylation
can provide useful information on the disease progression and the possible outcome of therapies. In the present study, we
have addressed post translational modifications of hemoglobin like glutathionylation and glycation in relation to diabetes
and chronic renal failure. We found that both alpha and beta chains of human hemoglobin are glycated irrespective of the extent
of glycemia as evidenced by a mass increment of 162 Da. The phenomenon of glutathionylation was observed with only the beta
globin chain of hemoglobin probably due to the presence of an accessible cysteine residue indicated by a mass increment of
305 Da. Also, the extent of gltuathionylation observed in the CRF patients could correlate with the severity of the oxidative
stress owing to renal replacement therapies like dialysis and transplantation. 相似文献
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We report a case of hemolytic anemia that was subsequently identified to be a case of α-thalassaemia harboring the common rightward 3.7 kb deletion/HbH. The diagnosis was based on sequential analyses using BioRad D10 HPLC, Alkaline gel electrophoresis, GPO α THAL-IC strips and the identification of the specific genetic lesion using an α Globin reverse dot blot hybridization assay. Supravital stain of RBCs helped in identifying classical HbH inclusions. In a background of a variable clinical presentation, lack of definitive hematological markers, and general under-diagnosis of α-thalassaemias we have used this case to highlight the features and sequence of techniques involved in identifying and characterizing an α-globin chain mutation, starting from a diffuse clinical history and presentation up to the identification of a specific genetic lesion involved. 相似文献
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