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Tertiary Education and Management - External quality audits have been introduced in many parts of the world including Asia Pacific, Asia, Africa, Europe, and the Middle East. While external quality... 相似文献
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S. Narayanan 《Indian journal of clinical biochemistry : IJCB》1996,11(1):12-16
A number of pre analytical variables affect lipid determinations. These include posture during blood sampling, the duration of tourniquet application and fasting, the time of day when blood is collected, the concentration and type of anticoagulant used for blood collection to name just a few. Effect of life style such as diet, alcohol and caffeine consumption, smoking, and exercise influence lipid determinations. Disease states such as infection, diabetes, nephrotic syndrome and heart disease culminating in myocardial infarction and conditions such as obesity and pregnancy influence lipid profiles. A variety of drugs ranging from diuretics to oral contraceptives to immunosuppressive drugs induce alterations in the patient's lipid profile. Post analytical variables impacting on the interpretation of laboratory data such as in the determination of the true mean of a lipid constituent would depend on the number of specimens analyzed, the analytical variability of the method and approaches to handling data such as the use of relative range to estimate the effect of biological variability on the computed mean value. 相似文献
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Kannan Vaidyanathan M. P. Narayanan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2011,26(4):319-325
Organic acidurias are an important class of inherited metabolic disorders arising due to defect in intermediary metabolic
pathways of carbohydrate, amino acids and fatty acid oxidation. This review summarizes the current knowledge about the important
organic acidurias in the Indian population. Specifically, diagnosis and principles of treatment of organic acidurias are covered.
The salient features of common organic acidurias as well as their prevalence in various parts of the world are reviewed in
some detail. 相似文献
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M. P. Narayanan Vaidyanathan Kannan K. P. Vinayan D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2011,26(4):347-353
Organic acid disorders are inherited metabolic disorders in which organic acids accumulate in tissues and biological fluids
of affected individuals. Classical organic acidurias include methylmalonic aciduria, propionic aciduria, isovaleric aciduria
and maple syrup urine disease (MSUD). They are considered the most frequent metabolic disorders among severely ill children.
Patients frequently present with acute symptoms early in life. 420 cases clinically suspected to have organic aciduria, with
upper age limit of 12 years for a 2-year period (January 2007–December 2008) were enrolled into this study. Metabolic acidosis
and neurological symptoms were the most common signs. Screening tests and thin layer chromatography were done for detection
of organic acidurias. Identification and quantitation of organic acids in urine and quantification of amino acids in blood
were done by high performance liquid chromatography. Out of 420 patients, 45 patients (10.7%) were found to have organic acidurias.
15 cases of methylmalonic aciduria, 16 cases of propionic aciduria, 13 cases of MSUD, and one case of isovaleric aciduria
were diagnosed. Results demonstrate the importance of testing for organic acidurias. Since organic aciduria may cause irreversible
brain damage if not treated, we recommend selective screening amongst severely ill children despite implied extra costs. 相似文献
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The Nobel Prize in Chemistry, 2012 has been awarded to Robert J Lefkowitz and Brian K Kobilka for their studies on G-Protein Coupled Receptors (GPCRs). GPCRs are receptor proteins present on the cell surface, which are involved in sensing molecules outside the cell and initiating a cellular response. They can sense a wide variety of ligands ranging from light to hormones and small peptides, triggering various physiological responses. Today we understand the molecular mechanisms by which these receptors work largely due to the contributions of Lefkowitz and Kobilka. Owing to the role of GPCRs in cell communication and involvement in various disease conditions, they are targets of over 40% of current drugs in the market. These findings have not only revealed how GPCRs work, but have also made a huge impact on the field of GPCR-associated drug discovery. 相似文献
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Private for-profit higher education has grown rapidly in many parts of the world. This growth is attributed to many factors, including a broadening of the student population and the recognition that wider access to higher education will be economically beneficial to individuals, governments and society as a whole. In Australia, the number of students in private for-profit higher education is rising, with dramatic projections for the next 10 years. The Australian government has set a target to increase the participation of students in higher education, with a focus on increasing the access and success of students from disadvantaged backgrounds. It is unclear, however, what role the burgeoning private for-profit institutions will play in meeting the government's targets, and what incentives will be provided for them to increase the access and participation of students from disadvantaged groups. This paper analyses the key drivers of growth in private for-profit higher education in Australia, and discusses issues around quality and standards. It examines the strengths and limitations of the sector, and the extent to which it contributes to diversity, access and the participation of students from disadvantaged backgrounds. It argues that the sector needs clear government directions to improve levels of access, and new government policies to encourage public-private collaborations to help ensure sustainability. The paper also briefly touches on the need for a review into the current structure of Australia's higher education sector as a whole, and whether higher education would benefit from the formation of public community colleges with the explicit aim of widening access for disadvantaged student groups. Further, the paper suggests that encouraging such public-private collaboration may be beneficial to ensure access and participation of students from all walks of life, including disadvantaged groups. 相似文献
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Over the past decade, companies worldwide have used corporate venturing (CV) as a means of revitalizing their operations, building new capabilities, and achieving strategic renewal, creating value for shareholders. Business interest in CV has stimulated academic interest in the topic, resulting in a rapidly growing but fragmented body of literature. Despite the growing international scholarly interest in CV, researchers have devoted little effort to integrating prior findings in a cumulative fashion. As a result, studies do not build upon one another, making it difficult to gauge the progress being made in addressing the fundamental research questions related to CV. In this paper, we examine the literature on CV seeking to synthesize, integrate and link its key findings. To do so, we analyze this literature over the past decade to identify its major themes and research findings setting the stage for greater coherence in future research on CV. We give special attention to the challenges and rewards of theory building in future CV research. Our review clearly shows that CV is an area of scholarly inquiry that has important implications for managerial practice. 相似文献
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Ashavaid T. F. Altaf A. K. Nair K. G. 《Indian journal of clinical biochemistry : IJCB》2000,15(1):11-16
Modification of platelet proteins by free radicals and glycation has been studied in the present work, as anin vitro model. The results of the two parameters, SDS-PAGE and carbonylation study are quite corroborative. We observed that the
inducers like ferrous sulphate, ascorbate (mainly in supraphysiological concentration) and glucose attack the protein in a
dose dependent manner, of which ferrous sulphate is most potent. Proteins from aged and degenerative conditions like malignancy
and diabetes mellitus have suffered greater damage than normal adult and foetal proteins. The individual life expectancy in
terms of biological versus chronological age may also be worked out from the individual stress level. 相似文献