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Abdorrahim Absalan Javad Mohiti-Ardakani Hossein Hadinedoushan Mohammad Ali Khalili 《Indian journal of clinical biochemistry : IJCB》2012,27(4):351-356
Cinnamon has been used as an anti-diabetic agent for centuries but only in recent few years its mechanism of action has been under investigation. Previous studies showed that cinnamon might exert its anti-diabetic effect via increasing glucose transporter isotype-4 (GLUT4) gene and glycoprotein contents in fat cells. To study if hydro-alcoholic cinnamon extract (HACE) enhances GLUT4 translocation from intracellular compartments of nuclear or endoplasmic reticulum membranes (N/ER) into the cytoplasmic membrane (CM). C2C12 myoblastic cell line were seeded in DMEM plus 20 % FBS and differentiated to myotubes using 2 % horse serum. After myotubes formation, 100 or 1,000 μg/ml HACE, as intervention, and as control 1 % DMSO were added for 3 h. Cells were washed and homogenized followed by ultracentrifuge fractionation, protein separation by SDS-PAGE and GLUT4 detection using semi-quantitative Western blotting. Data analysis was done by two-independent samples t test for comparison of mean ± SD of GLUT4 percent in categories. GLUT4 contents were higher in CM of groups 100 and 1,000 μg/ml HACE and lower in 1 % DMSO treated myotubes (CI = 0.95, P < 0.05). For N/ER reverse results were obtained (CI = 0.95, P < 0.05). As our results have shown HACE induces GLUT4 translocation from intra-cell into cell surface. We conclude that cinnamon maybe a choice of type-2 diabetes mellitus treatment because its extract enhances GLUT4 contents in CM where it facilitates glucose entrance into the cell. However it is necessary to trace the signaling pathways which are activated by HACE in muscular tissue. 相似文献
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Summaries English The purpose of this study was twofold: (1) to investigate the cognitive development of llth‐grade science students in Jordan; and (2) to investigate the relationship between cognitive development of science students and their comprehension of concrete and formal physics concepts. The sample of this study consisted of 389 secondary science students (209 males and 180 females) of the school year 1979‐1980. Cognitive development of the students was measured by an Arabic version of the Longeot Test. Comprehension of physics concepts was assessed by an achievement test constructed by the researchers and validated by teachers of physics and the science supervisor in the Irbid district of Jordan. The study did not reveal any significant difference between males and females in cognitive development. Moreover, it revealed that only 17% of the students were formal thinkers, whereas 52% were concrete thinkers. The 2×3 ANOVA revealed that cognitive level was a highly significant factor in the comprehension of both concrete and formal concepts. It also revealed that while sex was not a significant factor in the comprehension of concrete concepts, it was a significant factor in the comprehension of formal concepts. The interaction between sex and cognitive level was not significant in the comprehension of both types of concepts. 相似文献
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Large-eddy simulation of atmospheric flow is combined with golf ball trajectory modeling that incorporates local plant canopy information to predict the trajectory of a golf shot at any hole on a golf course in a variety of wind conditions. The model is applied to examine golf shots on hole 12 of the Augusta National Golf Club, which is particularly well known for its wind-induced difficulty. The results indicate that the tree canopies around this hole play a significant role in golf ball trajectories and also induce a strong directional sensitivity on the landing spot of the ball for this hole. 相似文献
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Neda Zdravkovic 《Public Services Quarterly》2013,9(1):48-64
The Future Voices in Public Services column is a forum for students in graduate library and information science programs to discuss key issues they see in academic library public services, to envision what they feel librarians in public service have to offer to academia, to tell us of their visions for the profession, or to tell us of research that is going on in library schools. We hope to provide fresh perspectives from those entering our field, both in the United States and other countries. Interested faculty of graduate library and information science programs, who would like their students' ideas represented in these pages, are invited to contact Nancy H. Dewald at nxd7@psu.edu. Neda Zdravkovic is studying at The School of Information Management at Victoria University of Wellington, New Zealand. Here she describes the student-centered and activity-based teaching approach used in some information literacy courses, including analysis of the student feedback received. The School of Information Management at Victoria University of Wellington teaches the only postgraduate library studies program in New Zealand. Students take courses on campus and by distance learning, using CD-ROM and Web-based materials, as well as Voice over Internet Protocol (VoIP) conferencing. The School is a member of the WISE (Web-based Information Science Education) consortium, sharing online courses with similar programs worldwide. From 2010, the current MLIS qualification will be replaced by postgraduate Certificate, Diploma and Master's degrees in Information Studies. The broad-based program allows students to specialize in Library Studies or in Archives and Records. Students come to the school from Asia, the United States, and New Zealand. 相似文献
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Neda Dadgar Maedeh Koohi Moftakhari Esfahani Sepideh Torabi Seyed Ebrahim Alavi Azim Akbarzadeh 《Indian journal of clinical biochemistry : IJCB》2014,29(4):501-504
This study is aimed to investigate the nanoliposomal artemisinin preparation, and its implementation on breast cancer cells. Side effects have been one of the common challenges of drug usage, as well as cancer treatment. In order to reduce such effects, nanotechnology has been a great help. Nanoliposomes are provided through reverse phase evaporation. In this method, certain proportions of phosphatidylcholine, cholesterol and artemisinin were mixed together. Besides, the obtained formulation was pegylated by using polyethylene glycol 2000 in order to increase its stability and solubility. The mean diameter of non-pegylated and pegylated liposomal artemisinin was determined by Zeta sizer system. The percent of drug released from liposome was performed by dialysis. The encapsulation efficiency of both formulations was estimated by spectrophotometry method. As a result, encapsulation and drug release of nanoliposomal formulation were more than the pegylation of the same formulation. In addition, this study indicated that cytotoxicity effect of pegylated nanoliposomal artemisinin was more, in comparison with nanoliposomal artemisinin. 相似文献
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As classrooms have increasingly become diverse and complex, developing culturally responsive pedagogies is a professional imperative for teachers. However, considerable international research suggests that meeting the needs of diverse pupil cohorts is challenging for many teachers. In this article, we highlight how curriculum and teaching practices reflect hegemonic values and cultural practices, and can potentially marginalise minority ethnic students. We draw on data from a study conducted in a culturally diverse lower secondary school in Austria where mandatory swimming classes are a source of tension between Muslim female students and their teachers. Our analysis of the intersection of student resistance and teacher authority raises issues of power, compliance and the construction of cultural difference as problematic. We suggest that scenario-based learning and in particular, the analysis of examples of student resistance and teacher response may facilitate teachers’ reflexivity about the values and beliefs that underpin their practice. 相似文献
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Exposing American K–12 students to science, technology, engineering, and math (STEM) content is a national initiative. Game Design Through Mentoring and Collaboration targets students from underserved communities and uses their interest in video games as a way to introduce science, technology, engineering, and math topics. This article describes a Game Design Through Mentoring and Collaboration summer program for 16 high school students and 3 college student mentors who collaborated with a science subject matter expert. After four weeks, most students produced 2-D video games with themes based on immunology concepts from the educational science game Immune Attack. Findings from three groups that finished their games and one group with an uncompleted game are explored. 相似文献
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Khalil Y. Khalili 《科学教学研究杂志》1987,24(2):127-136
A test for measuring science attitudes, named Test of Science Related Attitudes (TOSRA), was initially developed in Australia by Fraser (1977, 1978). This study investigated the crosscultural validity of this instrument when used with American high school students. Three hundred and thirty-six students (12th and 11th graders) in three high schools in suburban Chicago took the test. The results of the study, confirming previous validation of the test, revealed that the seven subscales of TOSRA were, in general, highly reliable. The discriminant validity of each of these scales, however, was found to be generally low. The item/scale correlation for all but four items of the test met Shrigley's (Journal of Research in Science Teaching, 20 (1), 87–89, 1983) criterion of being more than 0.30. The results of the principal components with varimax rotation did not support the distinctiveness of the subscale structure of the test. 相似文献