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1.
Bhawana Nigam S. P. Joshi Seema Nagar Rajesh Chavan D. Pendharkar 《Indian journal of clinical biochemistry : IJCB》1996,11(2):124-128
The analysis of biochemical parameters in 162 patients with various neoplastic disorders along with 50 normal subjects showed significant rise in serum alkaline phosphatase and lactate dehydrogenase as compared to normal subjects. 21 patients with other monoclonal gammopathies which include infection and immunological diseases were also studied. Parameters such as serum calcium, uric acid, total protein, albumin and globulin were also analyzed in 42 (26%) cases of multiple myeloma, 27 (17%) cases of gastro-intestinal malignancies, 22 (14%) cases of urogenital malignancies, 11 (6%) cases of carcinoma breast, 4 (2%) cases of bone tumors, 21 (12%) cases of other monoclonal gammopathies, including 7 (4%) cases of infection and 14 (8%) cases of immunological diseases. The results indicate use of enzymes alkaline phosphatase and lactate dehydrogenase in neoplastic disorders. 相似文献
2.
Caroline Dyer Archana Choksi Vinita Awasty Uma Iyer Renu Moyade Neerja Nigam 《比较教育学》2002,38(3):337-351
This paper argues for the need to adopt a more participatory and research-based approach to teacher development in India. Drawing on the experiences of a participatory teacher educator development project in three States, we discuss processes of developing a democratically orientated qualitative research team to work with teachers and teacher educators, highlighting the interplay between their education and socialisation and the demands of the methodology. In the second part of the paper, aspects of developing collaborative action research projects with teacher educators in the context of District Institutes of Education and Training are discussed. Both these approaches require the development of autonomy and critical reflexivity, and although there are tensions in this process, these emerge as vital components of developing a more democratic approach to teacher education. 相似文献
3.
Mauricio Garzon Olivier Dupuy Laurent Bosquet Anil Nigam Alain Steve Comtois Martin Juneau 《European Journal of Sport Science》2017,17(3):310-316
This study compared heart rate recovery (HRR) after incremental maximal exercise performed at the same external power output (Pext) on dry land ergocycle (DE) vs. immersible ergocycle (IE). Fifteen young healthy participants (30?±?7 years, 13 men and 2 women) performed incremental maximal exercise tests on DE and on IE. The initial Pext on DE was 25?W and was increased by 25?W/min at a pedalling cadence between 60 and 80?rpm, while during IE immersion at chest level in thermoneutral water (30°C), the initial Pext deployment was at a cadence of 40?rpm which was increased by 10?rpm until 70?rpm and thereafter by 5?rpm until exhaustion. Gas exchange and heart rate (HR) were measured continuously during exercise and recovery for 5?min. Maximal HR (DE: 176?±?15 vs. IE 169?±?12?bpm) reached by the subjects in the two conditions did not differ (P?>?.05). Parasympathetic reactivation parameters (ΔHR from 10 to 300?s) were compared during the DE and IE HR recovery recordings. During the IE recovery, parasympathetic reactivation in the early phase was more predominant (HRR at Δ10–Δ60?s, P?<?.05), but similar in the late phase (HRR at Δ120–Δ300?s, P?>?.05) when compared to the DE condition. In conclusion, incremental maximal IE exercise at chest level immersion in thermoneutral water accelerates the early phase parasympathetic reactivation compared to DE in healthy young participants. 相似文献
4.
Prabhat Kumar Nigam 《Indian journal of clinical biochemistry : IJCB》2016,31(2):237-239
The negative interference by bilirubin in serum creatinine estimation by Jaffe’s kinetic method is well known. Several approaches have been suggested to overcome this interference. In this article three different creatinine kits (Jaffe’s kinetic method) have been tested for bilirubin interference and its rectification using two simple approaches. The performance of three kits (A, B and C) supplied by three different manufacturers was tested using IQC and EQAS sera and pooled serum with added bilirubin. To overcome the bilirubin interference two approaches viz. NaOH preincubation and TCA precipitation were used. Bilirubin did interfere in creatinine estimation after a certain level (2.3 mg/dl). However, both NaOH preincubation and TCA precipitation approach rectified this interference. The performance of kit A was better than kit B and C. All the three kits showed bilirubin interference upon increasing the bilirubin concentration but kit A performed better than kit B and C. However, NaOH incubation and TCA precipitation methods overcame this interference to a great extent. 相似文献
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6.
When a charged capacitor is connected to another uncharged capacitor, the charge on the first one is shared by both and some
energy is lost through the connecting resistance. If this resistance is zero, it appears as though this energy is lost but
cannot be explained mathematically. Actually, in such a case, it is necessary to consider circuit inductance which leads to
oscillatory behaviour of the circuit. 相似文献
7.
Nigam PK 《Indian journal of clinical biochemistry : IJCB》2011,26(1):96-97
Serum lipid profile has now become almost a routine test. It is usually done in fasting state due to certain limitations in
non-fasting serum sample. In the recent past efforts have been made to simplify blood sampling by replacing fasting lipid
profile with non-fasting lipid profile. However, fasting specimen is preferred if cardiovascular risk assessment is based
on total cholesterol, LDL cholesterol or non-HDL cholesterol. A lot has yet to be done in this area. Till then we have to
believe in fasting lipid profile for assessment and management of cardiovascular disease. 相似文献
8.
P. K. Nigam A. Jain P. Goyal R. Chitra 《Indian journal of clinical biochemistry : IJCB》2005,20(2):43-47
Heat stable fraction (HSF) of alkaline phosphatase (ALP) was evaluated as an adjunct to CA 125 as a tumour marker for epithelial
ovarian cancer in a follow-up study. In our study group 63.4% of patients had elevated HSF levels (≥10U/L) and 93.3% had elevated
CA 125 levels (>35U/mL). The sensitivity of CA 125 and HSF was 93.3% and 63.3% respectively. The decline in the activity of
HSF, over the pre-op levels was highly significant after the first (p=0.001) chemotherapy cycle and significant after the
second and third cycles (p<0.029). Thereafter, HSF activity was almost undetectable. The decrease in CA 125 levels over the
pre-op levels was significant after the first, second, third (p<0.001) and fourth (p<0.034) chemotherapy cycle. HSF can be
used alone or as an adjunct to CA 125 in screening and monitoring patients of ovarian carcinoma especially in remote areas
where sophisticated facilities are not available and in patients in which CA 125 levels are not raised preoperatively. 相似文献
9.
Biochemical markers of myocardial injury 总被引：1，自引：0，他引：1
P. K. Nigam 《Indian journal of clinical biochemistry : IJCB》2007,22(1):10-17
The serum markers of myocardial injury are used to help in establishing the diagnosis of myocardial infarction. The older
markers like aspartate amino-transferase, creatine kinase, lactate dehydrogenase etc. lost their utility due to lack of specificity
and limited sensitivities. Among the currently available markers cardiac troponins are the most widely used due to their improved
sensitivity specificity, efficiency and low turn around time. Studies have shown that cardiac troponins should replace CKMB
as the diagnostic ‘gold standard’ for the diagnosis of myocardial injury. The combination of myoglobin with cardiac troponins
has further improved the accuracy in the diagnosis of acute coronary syndromes and thereby reducing the hospital stay and
patients' money. Among the other new markers of early detection of myocardial damage, heart fatty acid binding protein, glycogen
phosphorylase BB and myoglobin/carbonic anhydrase III ratio seem to be the most promising. But the search for the most ideal
marker of myocardial injury is still on. 相似文献
10.
Serum lipids and lipoproteins were estimated in 29 patients with acute myocardial infarction during acute phase (day 1,2,3),
predischarge and after three months. Serum total lipids, total cholesterol (TC) and LDL-cholesterol (LDLc) showed no significant
change during the hospital stay and three months followup. HDL-cholesterol (HDLc), however, started falling from day 2 onwards
with statistically significant reduction at pre-discharge and remained so at 3 months. The ratios of TC/HDLc and LDLc/HDLc
showed significant increase on predischarge day as compared to day 1. Serum triglycerides also showed an increasing trend
after myocardial infarction with a significant increase on day 3 and predischarge as compared to day 1. it is concluded that
the optimum time for assessment of serum lipid profile in patients with myocardial infarction seems to be within 24 hours
of the acute episode. 相似文献