To promote students’ value-based agency, responsible science and sustainability, science education must address how students think about their personal and collective futures. However, research has shown that young people find it difficult to fully relate to the future and its possibilities, and few studies have focused on the potential of science education to foster futures thinking and agency. We report on a project that further explored this potential by developing future-oriented science courses drawing on the field of futures studies. Phenomenographic analysis was used on interview data to see what changes upper-secondary school students saw in their futures perceptions and agentic orientations after attending a course which adapted futures thinking skills in the context of quantum computing and technological approaches to global problems. The results show students perceiving the future and technological development as more positive but also more unpredictable, seeing their possibilities for agency as clearer and more promising (especially by identifying with their peers or aspired career paths), and feeling a deeper connection to the otherwise vague idea of futures. Students also felt they had learned to question deterministic thinking and to think more creatively about their own lives as well as technological and non-technological solutions to global problems. Both quantum physics and futures thinking opened new perspectives on uncertainty and probabilistic thinking. Our results provide further validation for a future-oriented approach to science education, and highlight essential synergies between futures thinking skills, agency, and authentic socio-scientific issues in developing science education for the current age.