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Krishnan Gokuladhas Subramaniyan Jayakumar Balan Rajan Ramasamy Elamaran Chengalvarayan Subramani Pramila Mani Gopikrishnan Sasivarman Tamilarasi Thiruvengadam Devaki 《Indian journal of clinical biochemistry : IJCB》2016,31(2):171-184
Liver cancer is the fifth most common cancer and is still one of the leading causes of death world wide, due to food additives, alcohol, fungal toxins, air, toxic industrial chemicals, and water pollutants. Chemopreventive drugs play a potential role in liver cancer treatment. Obviously in the production of anticancer drugs, the factors like poor solubility, bioavailability, biocompatibility, limited chemical stability, large amount of dose etc., plays a major role. Against this backdrop, the idea of designing the chemopreventive nature of bio flavanoid hesperetin (HP) drug conjugated with pegylated gold nanoparticles to increasing the solubility, improve bioavailability and enhance the targeting capabilities of the drug during diethylnitrosamine (DEN) induced liver cancer in male wistar albino rats. The dose fixation studies and the toxicity of pure HP and HP conjugated gold nanoparticles (Au-mPEG(5000)-S-HP) were analysed. After concluded the dose fixation and toxicity studies the experimental design were segregated in six groups for the anticancer analysis of DEN induced HCC for 16 weeks. After the experimental period the body weight, relative liver weight, number of nodules and size of nodules, the levels of tumor markers like CEA, AFP and the level of lipid peroxidation, lipid hydroperoxides and the activities of antioxidant enzymes were assessed. The administration of DEN to rats resulted in increased relative liver weight and serum marker enzymes aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and gamma glutamyl transpeptidase. The levels of lipid peroxides elevated (in both serum and tissue) with subsequent decrease in the final body weight and tissue antioxidants like superoxide dismutase, catalase, reduced glutathione, glutathione peroxidise, and glutathione reductase. HP supplementation (20 mg/kg b.wt) significantly attenuated these alterations, thereby showing potent anticancer effect in liver cancer and the HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) treated animals shows the better treatment than the pure HP due to the solubility of drug, bioavailability and the target drug delivery of the biodegradable polymer. Histological observations were also carried out, which added supports to the chemopreventive action of the pure HP and HP loaded gold nanoparticles (Au-mPEG(5000)-S-HP) against DEN induction during liver cancer progression. These findings suggest that HP loaded gold nanoparticels (Au-mPEG(5000)-S-HP) shows better efficacy than the pure HP against lipid peroxidation, hepatic cell damage and protects the antioxidant system in DEN induced hepatocellular carcinogenesis. 相似文献
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Ramasamy Muthuveeran Pilz Matthias 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》2019,65(6):905-928
International Review of Education - Although India is one of the world’s fastest-growing economies, a large proportion of its people live in rural regions and is employed in the informal... 相似文献
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Chaos is a type of complicated behaviour found in non-linear dynamical systems. Computers are playing an important role in the growth of this science. 相似文献
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Abstract Teachers used a nonexclusionary time‐out package to treat inappropriate social behaviors that interfered with instructional tasks in four classrooms of preschool children, each containing an average of 16 students. We yoked classrooms on pretreatment scores of target behaviors and randomly assigned them to a time‐out ribbon plus praise or control condition. Students in the treatment condition wore wristbands with attached smiling face stickers and received praise from teachers for taking turns talking and remaining seated during group activities. Contingent on disruptive behavior, teachers removed the wristbands signaling a three‐minute time‐out period in which teachers restricted praise and attention but ongoing participation in activities continued. Multiple measures of treatment outcome were analyzed via MANCOVA and ANCOVAs. Behavior improved on direct observations of target behavior, the Preschool Behavior Questionnaire (PBQ) and items on a semantic differential, but not the Matson Evaluation of Social Skills with Youngsters. Treatment acceptability also supported treatment effects. We discuss implications of these results. 相似文献
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Chellachamy Manoharan Kasinathan Veeramuthu Ramdoss Venkatachalapathy Ramasamy Ilango 《浙江大学学报(A卷英文版)》2008,9(7):988-993
This study investigates the magnetic mineralogy and paleointensity values of a collection of archaeological artifacts （pottery）. The actual magnetic carriers and their domain states present in the archaeological pottery were obtained using the low field susceptibility, thermomagnetic curves and acquisition of isothermal remanence. The magnetic mineralogy of all the samples was dominated by ferrimagnetic mineral （magnetite/magnetite with low titanium content）, which was suitable for paleointensity measurements. The geomagnetic paleointensity value obtained by subjecting them to modified Thellier and Thellier method, is found to be （48.81±0.15） μT. 相似文献
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Haslinda Abdul HAMID Vahid Hosseinpour SARMADI Vivek PRASAD Rajesh RAMASAMY Azizi MISKON 《Journal of Zhejiang University. Science. B》2022,23(1):42-57
Mesenchymal stem/stromal cell(MSC)-based therapy has been regarded as one of the most revolutionary breakthroughs in the history of modern medicine owing to its myriad of immunoregulatory and regenerative properties.With the rapid progress in the fields of osteo-and musculoskeletal therapies,the demand for MSC-based treatment modalities is becoming increasingly prominent.In this endeavor,researchers around the world have devised new and innovative techniques to support the proliferation of MSCs while minimizing the loss of hallmark features of stem cells.One such example is electromagnetic field(EMF)exposure,which is an alternative approach with promising potential.In this review,we present a critical discourse on the efficiency,practicability,and limitations of some of the relevant methods,with insurmountable evidence backing the implementation of EMF as a feasible strategy for the clinically relevant expansion of MSCs. 相似文献
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Stephen B. Richards Ronald L. Taylor Rangasamy Ramasamy 《Psychology in the schools》1997,34(4):355-362
The accuracy of interpretation of single subject data was evaluated by comparing raters' visual analysis of behavior change with statistical determination of behavior change using the split-middle methods of trend estimation. In addition, the effects of rater background (undergraduate, graduate student) and characteristics of the fictitious student (gender, label) on the ratings were determined. Results indicated that the accuracy of visual analysis was less than chance (47%). Rater and student characteristics, for the most part, did not affect the ratings. Implications of these results are discussed. © 1997 John Wiley & Sons, Inc. 相似文献
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