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Ramesh Chander A. K. Khanna Kanwal Raj A. K. Rastogi 《Indian journal of clinical biochemistry : IJCB》2005,20(1):153-159
Indian black tea; CTC leaf and dust, produced by Tata Tea Limited, Kolkata, (India) was studiedin vitro as potential scavenger of oxygen free radicals. Super oxide anions were generated in a system containing xanthine—xanthine
oxidase (enzymic system) and by NADH- phenozine methosulphate (non enzymic system). Anions were assayed in terms of uric acid
formation and reduction of nitroblue tetrazolium salt, which were shown to be suppressed by tea extracts. Extracts from both
leaf and dust also inhibted the formation of hydroxyl radicalsin vitro in the enzymic system comprising hypoxanthine—Cu+2—sodium ascorbate and xanthine oxidase and in non enzymic system of deoxyribose—Cu+2—sodium ascorbate and H2O2 as well as the Cu+2 induced lipid peroxidation in human low density lipoprotein. Feeding with black tea in normal rats for sixty days increased
their antioxidant activity and their liver microsomes were shown to be protected against peroxidation of lipids as stimulated
by metal ions with enzymic or non enzymic reactants. Furthermore feeding with tea extracts in normal as well as triton WR—1339
induced hyperlipidemic rats caused decrease in their plasma levels of total cholesterol, phospholipids and triglycerides.
The antioxidant and lipid lowering activities of both extracts from CTC leaf and dust tea was comparable and may be due to
the presence of natural products like catechin and others. 相似文献
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Neelima Singh Vedika Rathore Roshan Kumar Mahat Puneet Rastogi 《Indian journal of clinical biochemistry : IJCB》2018,33(3):356-360
Cardiac markers are used to evaluate functions of heart. However, there are no satisfactory cardiac biomarkers for the diagnosis of acute myocardial infarction (AMI) within 4 h of onset of chest pain. Among novel cardiac markers, glycogen phosphorylase BB (GPBB) is of particular interest as it is increased in the early hours after AMI. The present study was conducted with the objective to find out the sensitivity and specificity of GPBB over other cardiac markers i.e. myoglobin and CKMB in patients of AMI within 4 h after the onset of chest pain. The study includes 100 AMI patients and 100 normal healthy individuals as controls. In all the cases and controls, serum GPBB and myoglobin concentrations were measured by ELISA where as CK-MB was measured by diagnostic kit supplied by ERBA. The sensitivity and specificity of glycogen phosphorylase BB (GPBB) were greater than CK-MB and myoglobin in patients of AMI within 4 h after the onset of chest pain. Hence, glycogen phosphorylase BB (GPBB) can be used as additional biomarker for the early diagnosis of AMI. 相似文献
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A novel technique for biomolecular detection in microliter droplets floating on the surface of high density oil is presented. Each droplet was captured and manipulated dielectrophoretically and was used as a site for a microscopic bioassay based on agglutination of antibody-conjugated particles. The results were read out by the pattern of unagglomerated gold nanoparticles collected on the droplet surface. Two formats of bioassays, namely gold only agglutination and gold and latex agglutination, were investigated experimentally by varying analyte concentration, particle size and concentration, number of antigen binding sites per particle, time for incubation, and rate of particle collection on the droplet surface. The microbioassays performance was also evaluated with ricin antibodies and compared to the ricin assays in field use. It is estimated that the droplet based assays require 100× smaller sample volume and are ten times more sensitive, though they require longer times to complete. The experiments were interpreted by modeling the kinetics of particle agglutination and mass transfer processes inside the droplets. The incubation time and antigen concentration values calculated by the model correlate well with the experimental results. The results could allow for development of efficient immunoassays on a chip requiring even smaller sample volumes. 相似文献
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Robin Patric Clair Rahul Rastogi Seungyoon Lee Rosalee A. Clawson Ernest R. Blatchley Charlotte Erdmann 《Qualitative Research Reports in Communication》2018,19(1):51-61
Open defecation persists as a global health problem despite efforts to build and implement better toilets. Based on nine focus group meetings held across two communities in rural Uttar Pradesh, India, this study shows that open defecation is a symbolic practice contributing to social and cultural identity formation. Major themes were derived regarding the positives and negatives of open defecation and latrine use. Open defecation was considered as a means for social communication, particularly for girls and women, and not necessarily as a healthier practice. Issues of politics and class relations emerged, with lower caste people expressing the lack of or poor quality toilets. Yet the persistence of historical and cultural identity played a part in people’s preference to go out to the field to defecate, especially for women to sustain their social connectedness and men to sustain their masculine identity. These cultural and communication aspects of open defecation should be considered in ongoing sanitation movements. 相似文献
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Ramesh Chander Kavita Singh A K Khanna S M Kaul Anju Puri Rashmi Saxena Gitika Bhatia Farhan Rizvi A K. Rastogi 《Indian journal of clinical biochemistry : IJCB》2004,19(2):141-148
Terminalia arjuna (T. arjuna) stem bark was successively extracted with petroleum ether (A), solvent ether (B), ethanol (C) and water (D). The lipid lowering
activity of these four fractions A, B, C, and D was evaluatedin vivo in two models viz., triton WR-1339 induced hyperlipemia in rats as well as fructose rich high fat diet (HFD) fed diabetic-
dyslipidemic hamsters. Hyperlipidemia induced by triton caused marked increase in the plasma levels of total cholesterol (Tc),
triglyceride (Tg) and phospholipids (PL) in rats. After treament withT. arjuna fractions A, B, C, and D at the doses of 250 mg/kg per oral (p.o.),only the ethanolic fraction (C) exerted significant lipid
lowering effect as assessed by reversal of plasma levels of Tc, Tg and PL in hyperlipidemic rats. In another experiment, feeding
with HFD produced marked dyslipidemia as observed by increased levels of plasma Tc, Tg, glucose (Glu), glycerol (Gly) and
free fatty acids (FFA) in hamsters. After treatment withT. arjuna fractions at the doses of 250 mg/kg p.o. only two fraction (B and C) could exert significant lowering in the plasma levels
of lipids and Glu. in dyslipidemic hamsters.In vitro experimentT. arjuna fractions at tested concentrations (50–500 μg/ml) inhibited the oxidative degradation of lipids in human low density lipoprotein
and rat liver microsomes induced by metal ions. These fractions when tested against generation of oxygen free radicals at
the concentrations (50–500 μg/ml), counteracted the formation of superoxide anions (O−2) and hydrodyl radicals (OH) in non enzymic test systems. The efficacy ofT. arjuna fractions as antidyslipidemic and antioxidant agents was found, fraction C> fraction B> fraction A. 相似文献
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Jaana Juvonen Leah M. Lessard Ritika Rastogi Hannah L. Schacter Danielle Sayre Smith 《教育心理学家》2019,54(4):250-270
The goal of this article is to provide a critical analysis of barriers to social inclusion and integration in schools and propose inclusive educational practices that help connect and unite diverse students. Diversity is defined broadly to refer to a range of differences (i.e., overall heterogeneity) across students. We review theoretical frameworks that help explain group dynamics and contextual conditions that contribute to exclusion (i.e., peer victimization, rejection, friendlessness) of students based on ethnicity, sexual orientation, body weight, and so on. We argue that to be able to facilitate inclusion (acceptance by peers, cross-group friendships), educators and school administrators need to be aware of group and interpersonal dynamics. They must also comprehend how some common school practices highlight differences and segregate students in ways that further promote divisions and reinforce negative stereotypes. We propose proactive school-based practices as “built-in” preventions to increase social inclusion. Also, relevant intervention approaches are reviewed. To conclude, we discuss teacher education and professional development and make recommendations for future research. 相似文献
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