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1.
Farrokhi E Shayesteh F Asadi Mobarakeh S Roghani Dehkordi F Ghatreh Samani K Hashemzadeh Chaleshtori M 《Indian journal of clinical biochemistry : IJCB》2011,26(3):244-248
Familial hypercholesterolemia (FH) is an autosomal dominant disorder of lipoprotein metabolism caused mainly by mutations
in the low-density lipoprotein receptor (LDLR) and apolipoprotein B 100 (APOB) genes. Until now, the molecular basis of FH
has been demonstrated in detail in many populations, but there is still very limited Molecular data concerning FH in Iran.
The aim of this study was to characterize the LDLR and APOB gene mutations in an Iranian population. A total of 30 non-related
Iranian possible FH subjects were studied. Diagnosis of FH was based on the Dutch Lipid Clinic Network diagnostic criteria.
All samples were initially tested for three common APOB gene mutations including R3500Q, R3500 W and R3531C using PCR-RFLP
assay. Subsequently, promoter and coding region of the LDLR gene was screened by PCR-SSCP analysis and positive results were
confirmed by DNA sequencing. Four previously reported polymorphisms 1413G > A, 1725C > T, 1773T > C and 2140 + 5G > A were
found in ~17% (5/30) of population studied. Moreover, no variation was found in APOB gene. Our data indicated that LDLR and
APOB gene mutations have not contribution to possible FH in Iranian population studied here. However, we examined three common
APOB mutations and LDLR in only 30 patients, and to determine the role of these genes in developing FH in Iran, more FH samples
and populations needed to be investigated for the mutations of the related genes. 相似文献
2.
Paulo Blikstein Tamar Fuhrmann Shima Salehi 《Journal of Science Education and Technology》2016,25(4):513-526
In this paper, we investigate an approach to supporting students’ learning in science through a combination of physical experimentation and virtual modeling. We present a study that utilizes a scientific inquiry framework, which we call “bifocal modeling,” to link student-designed experiments and computer models in real time. In this study, a group of high school students designed computer models of bacterial growth with reference to a simultaneous physical experiment they were conducting, and were able to validate the correctness of their model against the results of their experiment. Our findings suggest that as the students compared their virtual models with physical experiments, they encountered “discrepant events” that contradicted their existing conceptions and elicited a state of cognitive disequilibrium. This experience of conflict encouraged students to further examine their ideas and to seek more accurate explanations of the observed natural phenomena, improving the design of their computer models. 相似文献
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4.
Mohammad Salehi Mohammad Soltani Hadis Tamleh Shohreh Teimournezhad 《Learned Publishing》2020,33(2):89-95
The proliferation of predatory or bogus journals has been recognized as a threat to academic research, and this study was conducted to discover the experiences of authors published in these journals. Eighty authors who had published in journals identified as predatory were surveyed. We asked how the authors learnt about these journals, what they thought about the reputation of the journals, their experiences of peer review and the quality of feedback provided, and whether publication was driven by PhD or job requirements. Our results showed that a third of authors discovered the journals by web searches or responding to email invitations. Over half said the reputation and name of the journal were important in selecting a journal, although a third admitted that the journal they published in did not have a good reputation. The main reason for selecting the journals was the promise of fast publication (31.2% respondents). Only half of the respondents said that publication was driven by PhD or job requirements. Just over a third reported that peer review was good or excellent, and only 17.5% said that peer review was poor or non‐existent – over 70% thought they had received good feedback from the journals. Although the research was somewhat limited, it does indicate general satisfaction with the journals in which the authors published. Fast publication coupled with good feedback and encouragement to submit can make publishing in predatory journals so tempting that few authors can resist. 相似文献
5.
Mojtaba Salehi Isa Nakhai Kamalabadi Mohammad Bagher Ghaznavi Ghoushchi 《Education and Information Technologies》2014,19(4):713-735
Material recommender system is a significant part of e-learning systems for personalization and recommendation of appropriate materials to learners. However, in the existing recommendation algorithms, dynamic interests and multi-preference of learners and multidimensional-attribute of materials are not fully considered simultaneously. Moreover, these algorithms cannot effectively use the learner’s historical sequential patterns of material accessing in recommendation. For addressing these problems and improving the accuracy and quality of recommendation, a new material recommender system framework based on sequential pattern mining and multidimensional attribute-based collaborative filtering (CF) is proposed. In the sequential pattern based approach, modified Apriori and PrefixSpan algorithms are implemented to discover latent patterns in accessing of materials and use them for recommendation. Leaner Preference Tree (LPT) is introduced to take into account multidimensional-attribute of materials, and learners’ rating and model dynamic and multi-preference of learners in the multidimensional attribute-based CF approach. Finally, the recommendation results of two approaches are combined using cascade, weighted and mixed methods. The proposed method outperforms the previous algorithms on the classification accuracy measures and the learner’s real learning preference can be satisfied accurately according to the real-time up dated contextual information. 相似文献
6.
Mohammad Sadegh Cheri Hamidreza Shahraki Jalal Sadeghi Mohammadreza Salehi Moghaddam Hamid Latifi 《Biomicrofluidics》2014,8(5)
Measurement and control of pressure-driven flow (PDF) has a great potential to enhance the performance of chemical and biological experiments in Lab on a Chip technology. In this paper, we present an optofluidic flow sensor for real-time measurement and control of PDF. The optofluidic flow sensor consists of an on-chip micro Venturi and two optical Fabry-Pérot (FP) interferometers. Flow rate was measured from the fringe shift of FP interferometers resulted from movement fluid in the on-chip micro Venturi. The experimental results show that the optofluidic flow sensor has a minimum detectable flow change of 5 nl/min that is suitable for real time monitoring and control of fluids in many chemical and biological experiments. A Finite Element Method is used to solve the three dimensional (3D) Navier–Stokes and continuity equations to validate the experimental results. 相似文献
7.
Karimian Zahra Farrokhi Majid Reza Moghadami Mohsen Zarifsanaiey Nahid Mehrabi Manoosh Khojasteh Laleh Salehi Nasim 《Education and Information Technologies》2022,27(3):3299-3320
Education and Information Technologies - The COVID-19 crisis has had a profound effect on higher education, especially medical education due to its sensitive nature, dealing with people’s... 相似文献
8.
Reza Pishghadam Bob Adamson Shaghayegh Shayesteh Sadafian Flora L. F. Kan 《Assessment in Education: Principles, Policy & Practice》2014,21(1):34-51
Teacher burnout is an important phenomenon that affects the education system and society as a whole. Assessment represents a form of stress for teachers, and this study explores the association between teachers’ assessment-related beliefs and their burnout level. To this end, the Teachers’ Conceptions of Assessment (TCoA) inventory along with the Maslach Burnout Inventory were administered to a sample of Iranian teachers of English language. Multiple correspondence analysis and multiple regression analysis were employed for data analysis. The results reveal a significant relationship between TCoA and the three dimensions of burnout (emotional exhaustion, depersonalisation and reduced personal accomplishment). It is similarly found that conceiving of assessment as irrelevant to the life and work of teachers and learners is the best predictor of Depersonalisation and Personal Accomplishment, whereas Student Accountability is the best predictor of Emotional Exhaustion. Finally, the results are discussed and implications are provided in the context of education. 相似文献
9.
Maryam Ravanipour Shayesteh Salehi Fariba Taleghani Heidar Ali Abedi Marieke J. Schuurmans Anneke de Jong 《Educational gerontology》2013,39(10):923-938
Power is a resource for living that is present in all individuals, and has a positively uplifting effect on one's quality of life. In a grounded theory approach, we searched for factors influencing the sense of power, which exist in elders' interactions in their environment. These factors were awareness of personal changes, coping, role taking, perceived satisfaction, independence, and being in control. Self-management was at the core of all these factors. Educational interventions by health care professionals based on the elders' needs for empowerment comprise a major part of wellness approaches. 相似文献
10.
Hajar Ghadirian Keyvan Salehi Ahmad Fauzi Mohd Ayub 《The American journal of distance education》2018,32(1):27-42
An ego network is an individual’s social netwrk relationships with core members. In this study, the ego network parameters in online discussion spaces of high- and low-performing students were compared. The extent to which students’ ego networks changed over the course were also analyzed. Participation in 7 weeks of online discussions were analyzed for 12 high-performing students and 9 low-performing students. Results suggested that ego networks’ compositions of high- and low-performing students were significantly different. Particularly, high-performing students had denser ego networks and tended to exhibit a higher level of centralities than low-performing students. Results of network visualization indicated that high-performing students increased and kept their networks stable over the course in comparison to low-performing students, who had fragmented networks. Several networks’ change mechanisms for high- and low-performing groups are also identified and discussed. 相似文献