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申屠青松 《南京师范大学文学院学报》2007,(4):75-79
明代宋诗选本现可考者约有十五家。它们虽是对时人过度轻视宋诗的反驳,但也没有超越崇唐抑宋的时代风气,在选诗标准上多持以唐存宋的态度。明代宋诗选本保留了不少珍贵的宋诗文献,成为清代宋诗选本的文献来源之一,对清代宋诗复兴起过重要作用,但作为文献又有诸多缺陷,给清代选本带来不好的影响。 相似文献
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Jian Liu Jian-zhong Shentu Li-hua Wu Jing Dou Qi-yang Xu Hui-li Zhou Guo-lan Wu Ming-zhu Huang Xing-jiang Hu Jun-chun Chen 《Journal of Zhejiang University. Science. B》2012,13(5):348-355
In order to comply with the requirements for a drug listed in China, the study was developed to compare the pharmacokinetics
and relative bioavailability of two different enteric formulations of omeprazole (OPZ) in healthy Chinese subjects. A total
of 32 volunteers participated in the study. Plasma concentrations were analyzed by nonstereospecific liquid chromatography/tandem
mass spectrometric (LC-MS/MS) method. After administration of a single 40-mg dose of the two OPZ formulations, the comparative
bioavailability was assessed by calculating individual AUC0−t
(the area under the concentration-time curve from time zero to the last measurable concentration), AUC0−∞ (the area under the concentration-time curve extrapolated to infinity), C
max (the maximum observed concentration), and T
peak (the time to C
max) values of OPZ, 5-hydroxyomeprazole (OH-OPZ), and omeprazole sulfone (OPZ-SFN), respectively. The 90% confidence intervals
(CIs) of AUC0−t
, AUC0−∞, and C
max were 85.4%–99.0%/88.8%–98.6%/87.6%–99.4%, 85.5%–99.2%/89.0%–98.6%/88.5%–101.3%, and 72.3%–87.6%/79.6%–91.1%/88.4%–99.1% for
OPZ/OH-OPZ/OPZ-SFN, respectively, and T
peak values did not differ significantly. In this study, the test formulation of OPZ in fasting healthy Chinese male volunteers
met the Chinese bioequivalance standard to the reference formulation based on AUC, C
max, and T
peak. 相似文献
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申屠新飞 《温州职业技术学院学报》2001,1(1):49-51
新企业会计制度要求企业对盘盈盘亏的事项在期末结账前处理完毕，如果在期末结账前尚未批准处理，应在对外提供的财务会计报告中按已批准处理对待。下年度领导批准时，按资产负债表日后事项准则或会计差错更正方法进行处理。 相似文献
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Objective: To study the role of calpain in the mechanism of oxidative cataract through detecting the level of intracellular free Ca2 , the expression and proteolytic activity of calpain in the lens epithelial cells (LECs) of H2O2-induced cataract. Methods: Rat lenses were cultured in vitro and cataract was induced by H2O2. The level of intracellular free Ca2 was measured by fluorescence determination with fura-2/AM. The expression of m-calpain protein in LECs was detected with immunohistochemical method. The proteolytic activity in LECs was measured using a fluorogenic synthetic substrate. Results: There were significant differences of the level of intracellular free Ca2 (P=0.001, 0.000, 0.000), the expression of m-calpain (P=0.001, 0.000, 0.000) and the proteolytic activity of calpain (P=0.001, 0.000, 0.000) between H2O2-induced and control group at 6, 12 and 24 h, respectively. Conclusions: H2O2 can increase intracellular free Ca2 , then enhance the expression and proteolytic activity of calpain which may play a role in the mechanism of oxidative cataract of rat. 相似文献
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Huang MZ Shentu JZ Chen JC Liu J Zhou HL 《Journal of Zhejiang University. Science. B》2008,9(2):114-120
This study presents a rapid, specific and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) assay for determination of risperidone (RIS) in human serum using paroxetine as an internal standard (IS). An Alltima-C 18separation. The analysis was performed by selected reaction monitoring (SRM) method, and the peak area of the m/z 411.3→ 191.1 transition for RIS was measured versus that of the m/z 330.1→192.1 transition for IS to generate the standard curves. The assay linearity of RIS was confirmed over the range 0.25～50.00 ng/ml and the limit of quantitation was 0.05 ng/ml. The linear range corresponds well with the serum concentrations of the analytes obtained in clinical pharmacokinetic studies. Intraday and interday relative standard deviations were 1.85%～9.09% and 1.56%～4.38%, respectively. The recovery of RIS from serum was in the range of 70.20%～84.50%. The method was successfully applied to investigate the bioequivalence between two kinds of tablets (test versus reference products) in 18 healthy male Chinese volunteers. The result suggests that two formulations are bioequivalent. 相似文献
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“三位一体”就业招聘会。是高职教育探索者在改革实践中创造的一种全新的就业招聘方式，它把教师教、学生学与就业招聘结合为一个有机的整体，重构了教学过程，延伸了教学任务。它为毕业生和用人单位搭建了共用的平台，优化了就业用人环境，实现了正确办学方向和高水平办学的统一。必须进一步挖掘“三位一体”就业招聘会对高职办学的内在驱动力，寻找教学与就业的最佳结合点，以实现高职教育的培养目标。 相似文献
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本文阐述了金华大世界人在商业零售业经营普遍不景气的情况下，坚持“以人为本，外塑形象，内强管理”的企业营销理念，把传统的文化与企业的经营管理结合起来，创建独具特色的“大世界文化”，在激烈的商战中独占鳌头，一举成了金华商界的“巨人”，创新了商业零售业的竞争方式。 相似文献
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广枣提取液对小鼠免疫功能和运动耐力的影响 总被引：11，自引：0，他引：11
观察了广枣提取液对小鼠免疫功能、运动耐力的影响。结果表明：广枣提取液可明显增加小鼠耐缺氧时间，延长小鼠负重游泳时间，降低运动后小鼠血乳酸水平，显著提高其心肌组织中SOD活力；同时明显增加小鼠脾脏／体重、胸腺／体重比值，增强小鼠对巨噬细胞的吞噬能力．提高小鼠的细胞免疫、体液免疫功能。提示广枣提取液具有显著促进小鼠免疫功能及显著提高小鼠运动耐力的功效。 相似文献
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英语一般现在时除表示现在时间以外,还可以用来表达过去与将来时间。从一般现在时的实质现联性出发,以其两个基本特征——时间上的双向联系和心理上的现联性为依托,运用转喻认知机制对英语一般现在时语法形式和语法意义之间存在的矛盾进行了阐释,从而揭示一般现在时丰富的语法表意功能背后所隐藏的认知理据。 相似文献