Evaluation of the educational catchment area and decision-making support at the University of Szeged,Hungary     

Kovács  Ferenc  Mezősi  Gábor  Sipos  György  Mucsi  László 《Tertiary Education and Management》2014,20(2):106-120

The restructuring of Hungarian higher education according to European expectations has resulted in fundamental changes. Due to the intensifying market and the decreasing number of applicants, institutions are interested in ensuring the necessary number of students. The objective of the study is to identify those schools where the greatest interest in the courses offered by the University of Szeged can be expected. The selection was based on spatial and temporal analysis of submitted applications using geographical information system methods. The results can contribute to attracting the necessary number of students and to developing a sound basis for future educational planning.  相似文献   

Microfluidic study of the chemotactic response of Escherichia coli to amino acids,signaling molecules and secondary metabolites     

Krisztina Nagy  Orsolya Sipos  Sándor Valkai  éva Gombai  Orsolya Hodula  ádám Kerényi  Pál Ormos  Péter Galajda 《Biomicrofluidics》2015,9(4)

Quorum sensing and chemotaxis both affect bacterial behavior on the population level. Chemotaxis shapes the spatial distribution of cells, while quorum sensing realizes a cell-density dependent gene regulation. An interesting question is if these mechanisms interact on some level: Does quorum sensing, a density dependent process, affect cell density itself via chemotaxis? Since quorum sensing often spans across species, such a feedback mechanism may also exist between multiple species. We constructed a microfluidic platform to study these questions. A flow-free, stable linear chemical gradient is formed in our device within a few minutes that makes it suitable for sensitive testing of chemoeffectors: we showed that the amino acid lysine is a weak chemoattractant for Escherichia coli, while arginine is neutral. We studied the effect of quorum sensing signal molecules of Pseudomonas aeruginosa on E. coli chemotaxis. Our results show that N-(3-oxododecanoyl)-homoserine lactone (oxo-C12-HSL) and N-(butryl)-homoserine lactone (C4-HSL) are attractants. Furthermore, we tested the chemoeffector potential of pyocyanin and pyoverdine, secondary metabolites under a quorum sensing control. Pyocyanin is proved to be a weak attractant while pyoverdine are repellent. We demonstrated the usability of the device in co-culturing experiments, where we showed that various factors released by P. aeruginosa affect the dynamic spatial rearrangement of a neighboring E. coli population, while surface adhesion of the cells is also modulated.  相似文献