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The effect of sodium pentosan polysulphate (SPP), was studied in relation to certain blood and erythrocyte membrane parameters in calcium oxalate stone forming rats. Calcium oxalate stones were induced by feeding the rats with 3% w/w sodium glycollate. Fibrinogen, haemoglobin and serum protein levels did not show any variation with the treatment procedures. Serum mucoprotein and protein bound carbohydrates-hexosamine and sialic acid-were increased significantly in the rats receiving calculogenic (CPD) and attained nearly normal levels with SPP treatment. In contrast, hexuronic acid level was decreased in the CPD group and SPP administration increased the level of hexuronic acid in the treated groups. Erythrocyte membrane Ca2+-ATPase activity was increased in stone forming rats and SPP administration brought a reduction in the above enzyme activity. Changes in Membrane Mg2+- and Na+, K+-ATPases were minimal. Membrane cholesterol and phospholipids were also raised significantly in stone formers, SPP treatment reduced the membrane cholesterol levels in both controls and stone formers. Phospholipids were also decreased moderately. The above observations suggest that SPP is safe for administration in urolithiatic condition without adverse effects. 相似文献
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The effect of sodium pentosan polysulphate (SPP) in calcium oxalate stone forming rats was studied in relation to enzymatic changes in liver. A significant increase in liver glycollate oxidase (GAO) activity was observed in stone forming rats fed sodium glycollate. SPP treatment lowered the enzyme acitivity in both stone formers and 30 days drug treated control rats. Moderate elevation in LDH activity was seen in the calculogenic group and SPP had minimal effect. The lowering of alkaline and acid phosphatase activities in stone formers was normalised with drug administration. Increases in total, Na+, K+-and Ca2+-ATPase levels in the calculogenic rats was lowered considerably with SPP treatment. Inorganic pyrophosphatase and aminotransferases were slightly reduced in glycollate-fed rats. SPP administration further lowered the pyrophosphatase level. The decrease in liver GAO during SPP administration with a consequent reduction in kidney oxalate may prove beneficial in preventing recurrence. 相似文献
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Varalakshmi Sontam George Gabriel 《Community College Journal of Research & Practice》2013,37(10):808-820
Previous research shows that there are individual differences in academic achievement associated with gender and race. Research also suggests that student engagement is an important determinant of student outcomes/achievement. The present study explored student engagement at an extra-large community college. It specifically investigated possible individual differences in student engagement and explored how it maps on to student achievement. As predicted, the results indicate that there are gender and race differences in student engagement—females show greater engagement than males, and African-American students show greater engagement than students of other races. The results are discussed in the context of student achievement as indicated by students’ self-reported GPAs. 相似文献
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The effect of DL α-lipoic acid, a potent antioxidant was studied in relation to certain erythrocyte membrane parameters in
calcium oxalate stone forming rats. Induction of calcium oxalate lithiasis was done by feeding a diet containing 3% w/w sodium
glycollate. Erythrocyte membrane (Na+, K+)-ATPase showed a significant decrease in stone formers whereas (Ca2+)-ATPase showed a significant increase. Lipoic acid administration brought about an elevation in the activity of (Ca2+)-ATPase. Changes in membrane (Mg2+)-ATPase was minimal. Membrane cholesterol and phospholipids were found raised significantly in lithogenic rats. The changes
may be attributed to enhanced lipid peroxidative mechanisms and altered serum lipid profile observed in this group. Treatment
with lipoic acid reduced membrane cholesterol levels. Phospholipids were also decreased moderately. The above observations
suggest that lipoic acid administration to calculogenic rats reduces the erythrocyte strucutral changes observed in this condition. 相似文献
5.
R. Baskar N. Saravanan P. Varalakshmi 《Indian journal of clinical biochemistry : IJCB》1995,10(2):98-102
The influence of Crataeva nurvala bark decoction was studied in calcium oxalate stone forming rats, in relation to oxalate
metabolism in liver. The activities of the major oxalate synthesizing enzymes in liver namely, glycollate oxidase (GAO) and
lactate dehydrogenase (LDH) were significantly increased in the calculogenic group. Bark decoction treatment lowered the liver
GAO activity considerably. Transport ATPases (Na+, K+ and Ca2+-ATPases) and alkaline phosphatase were enhanced in rats fed calculi producing diet, while the activities of acid phosphatase,
inorganic pyrophosphatase and aminotransferases were slightly reduced. Bark decoction administration produced a marginal decrease
in Na+, K+-ATPase and increase in aspartate aminotransferase activities, without significantly altering other enzyme activities. The
decrease in liver GAO activity seen during bark decoction treatment, with concomitant decrease in kidney oxalate level, may
prove beneficial as a prophylactic measure in preventing stone recurrence. 相似文献
6.
The influence of L(+)-tartrate on liver cell constituents were investigated, during experimental stone formation in rats.
A significant increase in the liver glycollate oxidase activity was observed in the calculogenic group. Tartrate administration
had a considerable lowering effect on the liver glycollate oxidase activity and it also lowered the urinary excretion pattern
of oxalate. The rats fed with calculi producing diet also exhibited moderately enhanced LDH, (Na+, K+)—and (Ca2+)—ATPase activities. The activities of inorganic pyrophosphatase and aminotransferases were slightly reduced. Acid phosphatase
activity was significantly reduced with tartrate treatment. The use of tartrate in urolithiasis as a prophylactic measure
to prevent recurrence may be beneficial. 相似文献
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