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Present investigation shows that hydroethanolic extract of Moringa oleifera (MOHE) and its isolated saponin (SM) attenuates DMBA induced renal carcinogenesis in mice. Isolation of SM was achieved by TLC and HPLC and characterization was done using IR and 1H NMR. Animals were pre-treated with MOHE (200 and 400 mg/kg body weight; p.o), BHA as a standard (0.5 and 1 %) and SM (50 mg/kg body weight) for 21 days prior to the administration of single dose of DMBA (15 mg/kg body weight). Administration of DMBA significantly (p < 0.001) enhanced level of xenobiotic enzymes. It enhanced renal malondialdehyde, with reduction in renal glutathione content, antioxidant enzymes and glutathione-S-transferase. The status of renal aspartate transaminase, alanine transaminase, alkaline phosphatase and total protein content were also found to be decreased along with increase in total cholesterol in DMBA administered mice. Pretreatment with MOHE and SM significantly reversed the DMBA induced alterations in the tissue and effectively suppressed renal oxidative stress and toxicity. 相似文献
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P. C. Deshmukh Parth Rajauria Abiya Rajans B. R. Vyshakh Sudipta Dutta 《Resonance》2017,22(9):847-866
The brachistochrone problem posed by Bernoulli and its solution highlights one of the most famous experiments in physics which illustrates the variational principle. This pedagogical study is designed to ignite a classroom discussion on the variational problem. We overview the Euler–Lagrange formalism of the variational principle and obtain the solution to the brachistochrone problem. We demonstrate the success of the variational method using brachistochrone models which were fabricated specially for this purpose. 相似文献
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Urinary abnormalities were evaluated in 100 renal stone patients with first episode of renal stone having age 22 to 45 years
from both sex and compared to 100 normal healthy control group having same age group from both sex. Twenty-four hours urinary
oxalate, calcium, uric acid, sodium, magnesium, phosphorus and citrate were estimated. The urinary pH was also determined.
In stone formers urinary oxalate, calcium, sodium and uric acid excretions were significantly higher when compared with control
group. Whereas citrate, phosphate and magnesium excretion were significantly lower in stone formers when compared with control.
The pH of urine in stone formers was lower than the controls. High dietary intake of purine rich diet causes elevated excretion
of uric acid, which leads to calcium oxalate crystal formation and precipitation. Other risk factors such as urinary oxalate,
calcium also related to formation of renal calculi.
Hypocitraturia is the main cause of renal calculi along with hypomagnesiuria and hypophosphaturia in the patient of Marathwada
region. On the basis of urinary abnormalities further stone formation in the patient can be prevented by dietary modifications. 相似文献
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With increasing student migration for Higher Education to Karnataka, it is important to understand the reasons which influence the migrants. Studies have indicated various push and pull factors for migration. This paper identifies career opportunities, value for education, brand equity, living conditions and others as pull factors of student migration using exploratory factor analysis. Further, the paper develops a structural equation model using a partial least square technique based on the factors explored. The research is based on primary data collected from students who migrated to Karnataka for Higher Education. The partial least square structural equations model shows that job opportunities and academic progression are the main factors influencing the decision to migrate to Karnataka. 相似文献
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Veena Nath 《International journal of qualitative studies in education》2013,26(6):663-670
Stereotypical notions of who experiences homelessness frame how educational institutions approach policy and program development. This life history of a teacher challenges assumptions by providing an in-depth look at a mother’s struggle to find stability. 相似文献
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Deborah Fields Veena Vasudevan Yasmin B. Kafai 《Interactive Learning Environments》2015,23(5):613-633
We highlight ways to support interest-driven creation of digital media in Scratch, a visual-based programming language and community, within a high school programming workshop. We describe a collaborative approach, the programmers’ collective, that builds on social models found in do-it-yourself and open source communities, but with scaffolding structures that support students’ learning. We analyze the work of a class of high school student collectives engaged in programming music videos as part of a collaborative challenge in the online Scratch community. Our multi-level analysis focused on students’ learning specific programming concepts, effects of collaborative and task design on learning, and their personal reflections on collaboration and media creation. We address how these overlapping collaborative experiences point to the value of “nested collectives,” or multiple levels of designed-for collaboration. We also highlight a needed shift from a focus on computation to computational participation, highlighting the innately social aspects of media creation. 相似文献
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Vijetha Shenoy Veena Mehendale Krishnananda Prabhu Ranjan Shetty Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2014,29(3):339-344
Coronary artery disease (CAD) has become the most common cause of mortality in the entire world. Homocysteine is implicated as an early atherosclerotic promoter. We studied the relationship between levels of serum homocysteine with severity of coronary artery disease. Total of 70 subjects who scheduled for coronary angiogram consented to participate in this study. In all the patients Gensini scoring system was used to assess the severity of CAD. Venous samples were taken from the patients in fasting state before angiography. Homocysteine levels in patients were measured by enzyme linked immunosorbant method and were compared with respective Genseni scores of participants. Fasting serum homocysteine levels in CAD patients were significantly higher than patients without coronary artery disease (p < 0.001). Also Homocyseine levels correlated significantly with increasing severity of CAD (p < 0.001). Serum homocysteine levels correlated well with the severity of CAD. 相似文献
8.
Chand Vijaya Sherry Deshmukh Ketan Satish Shukla Anurag 《Educational technology research and development : ETR & D》2020,68(5):2753-2774
Educational technology research and development - This paper explores technology integration and the role of teacher beliefs in this integration to assess a ‘smart-class’ initiative... 相似文献
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Fatigue reliability analysis of fixed offshore structures： A first passage problem approach 总被引：1，自引：0，他引：1
MADHAVAN PILLAI T.M VEENA G. 《浙江大学学报(A卷英文版)》2006,7(11):1839-1845
INTRODUCTION Offshore production and drilling platforms are, in general, large and complex structural systems, usually fabricated using steel tubular members interconnected through welded joints. These structures are predomi- nantly subjected to oscillatory environmental loads and fatigue characterizes a primary mode of failure of their components. The fatigue damage at any point in the structure depends on the complete stress history during the structure’s service life. The calculation … 相似文献