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The interaction of lexical and non-lexicalprocesses in spelling was investigated throughlexical priming of non-lexical spelling, inPolish, a language in whose relativelytransparent orthography lexical informationmight be expected to play a less influentialrole than in English. Orthographic choice fornonwords was assessed under free and primedspelling conditions for both adults andchildren using direct and associative priming.The findings indicated that lexical orthographyinfluences resolution of nonlexical phonologyin spelling and identified two sources ofinfluence: one in unprimed spelling, wherelong-standing orthographic knowledge affectednonword orthographic choice so that it was notdetermined solely by phonology, the other inprimed spelling, where orthographic solutionsto nonwords were influenced by the covertorthography of the prime. The most powerfulevidence for lexical influence comes from thefinding that lexical orthography not onlyinforms resolution of phonology in cases ofambiguity, but overrides phonology whenresolution is unambiguous.  相似文献   
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目的:评估可溶性血管细胞间黏附分子(s VCAM-1)、可溶性细胞间黏附分子(s ICAM-1)、可溶性选择素E和可溶性血栓调节蛋白在血糖控制良好和不受控制的2型糖尿病患者中的水平。创新点:对2型糖尿病患者的血管内皮炎症标记物进行评估。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中s VCAM-1、s ICAM-1、可溶性选择素E和可溶性血栓调节蛋白的浓度,同时测定血清肌酐及血浆中空腹血糖和糖化血红蛋白(Hb A1c)的浓度。结论:与血糖控制良好的糖尿病组相比,未控制血糖组具有相对低的ICAM-1水平和更高的VCAM-1水平。未控制血糖组中患者的糖化血红蛋白和ICAM-1之间呈正相关,肾小球滤过率和可溶性选择素E之间呈正相关,而肌酐和ICAM-1之间呈负相关。研究证实2型糖尿病的发病机理中炎症过程的出现与血管内皮功能受损有关。未受控制的高血糖对粘附分子的反向作用表明,在糖尿病的并发症中VCAM-1和ICAM-1具有不同功能。  相似文献   
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It has previously been reported that exposure to visually presented correctly and incorrectly spelled words has a significant effect on subsequent spelling accuracy. Previous research investigating this process in skilled adult readers has shown very robust effects that encountering a misspelling has a detrimental effect on spelling accuracy whereas encountering a correct spelling has a beneficial effect. This effect is considered to be mediated via an implicit priming mechanism. In the current study, children with a mean age of 10 years were tested using a similar procedure to the experiments with adults but the results revealed a qualitatively different pattern. Children showed a significant beneficial effect following presentation of a correct spelling but no measurable effect of encountering a misspelling on subsequent spelling accuracy. The fact that children's spelling output was also found to be affected by depth of encoding at the point of presentation points towards an explanation of children using explicit rather than implicit processing of prior information.  相似文献   
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Until recently pedagogics has concentrated on elementary and secondary education. With the expansion of higher education it is important to apply the principles of pedagogic theory to higher education. Qualitative, as well as quantitative aspects should be considered. The aim should be to develop a system which is effective and adequate in terms of the needs of contemporary society.
La pedagogie de l'enseignement superieur: Problemes de recherche
Résumé La recherche pédagogique s'est jusqu'ici attachée principalement aux problèmes de l'enseignement primaire et secondaire. L'expansion de l'enseignement supérieur exige aujourd'hui que l'on applique les principes de la théorie pédagogique à ce type d'enseignement. Il convient de prendre en compte aussi bien les aspects qualitatifs que les aspects quantitatifs de la question. Le but recherché devrait être de mettre en place un système efficace et adapté aux besoins des sociétés contemporaines.
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Much was said and written during the 2005 World Year of Physics about Einstein's work in the Bern, Switzerland, Patent Office(Fig. 1). He took the post(Technical Expert 3rd Class)there after completing his studies at the Zurich Polytechnic(later called ETH) in 1900 and being unsuccessful in his attempts to obtain a university position. However,little seems to be known of the patent applications he examined during his five years at the office in Bern. This paper discusses one of those applications--one that was submitted by rather remarkable individual.  相似文献   
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Objective

Decompensated chronic hyperglycemia often leads to late microvascular complications such as retinopathy, diabetic foot syndrome, and diabetic kidney disease. The aim of this study was to determine the concentration of vascular endothelial growth factor A (VEGF-A) and its receptors in patients with well-controlled diabetes.

Methods

The study was conducted on 31 patients with well-controlled type 2 diabetes without micro-or macroangiopathy. Thirty healthy volunteers were enrolled in a control group. Serum concentrations of VEGF-A, VEGF receptors 1 and 2 (VEGFR1 and VEGFR2), fasting glucose, and lipid profiles were measured, and the plasma concentration of glycated hemoglobin (HbA1c) was determined.

Results

No significant differences were observed between the concentration of VEGF-A, VEGFR1 or VEGFR2 in the subject group and that in the control group. Positive correlations were noted between the levels of VEGF-A, VEGFR2, and triglyceride, and there was a negative correlation between the levels of VEGFR2 and high-density lipoprotein (HDL)-cholesterol in the study group.

Conclusions

The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays the occurrence of vascular complications. A negative correlation between VEGFR2 and HDL-cholesterol levels, and positive correlations between VEGF-A, VEGFR2, and triglyceride levels, suggest that lipid abnormalities occurring in diabetes may be involved in the modulation of angiogenesis.  相似文献   
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Child protection (CP) has risen to the top of the UK sports policy agenda in the past four years and the Football Association has invested in this major strategy as part of its commitment to ‘use the power of football to build a better future’ (Football Association, 2000a). Evidencing the impact of child protection is, however, a complex task, exacerbated by the dearth of measurement tools that exist for this purpose in sport. This article presents a new model of ‘Activation States’ that has been designed and used to measure shifts in football culture as child protection has begun to impact upon the sport. The model is used to map changes over time related to the knowledge, feelings, actions and discourses of key stakeholders in football. The research for which the model was designed is a longitudinal study, commissioned by the English Football (soccer) Association, on the impact of the organisation's child protection strategy on the culture of soccer. Sample data from the project are used to illustrate the model and to examine its potential and limitations as a tool for measuring impacts in child protection and other social inclusion themes.  相似文献   
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Expanding on the robust contributions by feminist new materialist scholars this essay focuses on two concepts—affect and rhythm—in order to elaborate on matters of pedagogy and a politics of attunement. If one of the key challenges that arises from feminist new materialism is that the human can no longer be taken for granted, then this prompts us to open ourselves to other ways of thinking, knowing, and doing. Being attuned to the agency of all matter offers a way of looking at how pedagogy is constituted as material, affective, and in rhythm, and this attention to the mechanisms of pedagogy can in turn affect a politics of attunement. In order to problematize an affective pedagogy we turn to a socially enagaged performance called The Artists’ Soup Kitchen.  相似文献   
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