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Sultana Furruqh D. Anitha T. Venkatesh 《Indian journal of clinical biochemistry : IJCB》2004,19(2):72-79
Reference intervals in clinical chemistry are commonly based on results of measurements in reference western population or
are taken from the western literature. Reference Values are thought to aid physicians to interpret results of measurements
and, should be representative of a defined group of individuals. This group should be as similar as possible to the patients
under investigation. The reference population in this, study has been recruited from the individuals attending the Health
Plan Clinic who fulfill the defined inclusion and exclusion criteria as well as defined partition criteria. The samples were
sorted based on the decision by the physician. The emerging group of individuals was considered as a reference population
for the hospital patients and the results of measurements in this study was evaluated statistically, to stress on the urgent
need to establish the in-house reference values. The reference limits are defined as the central 95 percentile of the population
after eliminating the outliers. The lower, reference limit is the 2.5 percentile while the upper reference limit constituted
the 97.5 percentile for the population. 相似文献
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S. Jaya Kumari Ganapathy Bantwal Anitha Devanath Vageesh Aiyyar Madhuri Patil 《Indian journal of clinical biochemistry : IJCB》2015,30(2):217-220
Vitamin B12 deficiency has been reported in patients with Autoimmune thyroid disorders. However there is limited data on exact prevalence of low B12 and its correlation with anti-thyroperoxidase antibody (anti-TPO) levels in these patients. The aim of our study was to estimate serum vitamin B12 levels in autoimmune thyroid disorders and to correlate B12 levels with anti-TPO. 350 patients were selected by convenient sampling. Vitamin B12 levels and thyroid parameters were estimated using fully automated chemiluminescence method on Access 2. Results of our study shows that using the manufacturer’s cut-off of 145 pg/mL, the prevalence of low serum vitamin B12 was found to be 45.50 %. Higher prevalence (55 %) was seen based on the published cut-off of 200 pg/mL The study however did not demonstrate any significant correlation between vitamin B12 levels and anti-TPO (r = −0.11 and p value of 0.30).
Electronic supplementary material
The online version of this article (doi:10.1007/s12291-014-0418-4) contains supplementary material, which is available to authorized users. 相似文献3.
O. P. Sanjay Anitha Devnath B. C. Thejas 《Indian journal of clinical biochemistry : IJCB》2005,20(1):98-102
This study sought to investigate the effects of α-stat and pH stat regimens on cardiac outcome during moderate hypothermic
cardiopulmonary bypass. 100 patients undergoing elective coronary artery bypass grafting (CABG) were randomly assigned with
respect to the target value for PaCO2 during cardiopulmonary bypass (CPB) into 2 groups. In 50 patients the target PaCO2 was 40 mmHg, measured at a standard electrode temperature of 37°C while in the other 50 patients the target PaCO2 was 40 mmHg, corrected to the patients nasopharyngeal temperature (lowest value reached: 32±0.5°C). There were no significant
differences between groups with regards to cardiac outcome such as appearance of new ‘Q’ waves on the electrocardiogram, postoperative
creatinine kinase-MB fraction, systemic vascular resistance (SVR), cardiac index (Cl), need for inotropic or intra-aortic
balloon pump support and the length of postoperative ventilation or intensive care unit stay. These findings support the hypothesis
that CO2 management during CPB at moderate hypothermia has no clinically significant effect on cardiac outcome. 相似文献
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Anitha Devanath Somdattaa Ray Ravi Kumar B. S. Prarthana 《Indian journal of clinical biochemistry : IJCB》2014,29(1):45-50
HIV infection is associated with lipid abnormalities in treatment naïve patients. CD4 count is used for monitoring the HIV infection. Primary objective was to evaluate and correlate lipid profile and CD4 counts in HIV infection. Secondary objective was to evaluate the feasibility of using Lipid profile to monitor the HIV infected treatment naïve patients instead of CD4 counts. 112 patients were selected based on a criteria from ART center in tertiary care center. CD4 counts were assessed and Lipid profile was evaluated enzymatically. A correlation study was done between the lipid profile and the CD4 count and clinical stages of infection. Cholesterol showed no significant correlation in any stage. HDL-C showed significant correlation (p < 0.05) with stage 2 and 4 disease. LDL-C showed no significant correlation in any stage. TGL showed significant correlation (p < 0.05) at stage 4 disease. Hence, HDL-C and TGL can be used as indicators of lipid status and for infection progression in treatment naive HIV patients, while Cholesterol and LDL-C has no role to play. 相似文献
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Anitha Devanath Jaya Kumari Jim Joe Saly Peter Sugirtha Rajan Laly Sabu Shivshankar Janet Mary Smitha Roselin Arokiasami 《Indian journal of clinical biochemistry : IJCB》2009,24(4):361-365
This retrospective study was conducted to assess the serum lipase / amylase ratio in acute pancreatitis for South Indian population attending the clinics of Gastroenterology and Emergency medicine in the last five years. One thousand one hundred and thirty two patients (768 males and 364 females) with acute pancreatitis (AP) were selected for the study. The diagnosis of AP was based on clinical evaluation, Computed Tomography (CT) findings and biochemical parameters such as serum lipase and amylase. Based on the etiology, the groups were divided into alcoholic, biliary and miscellaneous AP. Based on CT findings, groups were divided into mild, moderate and severe AP. Serum lipase, amylase and lipase / amylase ratio were calculated and statistically analyzed. Serum lipase levels in alcoholic group (3226.3 ± 1384.7) were significantly lower in comparison to biliary (6064.5 ± 1640.8) group though the levels were not significantly different from miscellaneous group (2132.3 ± 1210). Serum amylase values were significantly lower in alcoholic group (923.4 ± 557.5) in comparison to biliary (1736.2 ± 390.7) and there was significant difference between alcoholic and miscellaneous group (535.8 ± 477.6). The serum lipase / amylase ratio > 4 occurred in alcoholic group than with biliary and miscellaneous group. The sensitivity and specificity to predict alcoholic AP with lipase / amylase ratio at >4.0 was 84 % and 59 % respectively. In conclusion the serum lipase to amylase ratio greater than 3.0 could be used to differentiate but keeping the cut off at 4.0 would be of higher sensitivity without much change in specificity. The serum lipase to amylase ratio with a cut off of 3.0 or greater is not useful to differentiate the severe AP from milder AP. Hence, serum amylase and lipase are important for evaluation of pancreatitis though it is not a gold standard for the diagnosis or assessment of severity of acute pancreatitis. 相似文献
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Fifty patients were evaluated for serum total PSA (Prostate Specific Antigen), free PSA (f-PSA), free/total PSA ratio (f/t
PSA ratio) and TPSTM (Tissue Polypeptide Specific Antigen). Fifty patients were clinically evaluated and categorized into BPH (benign prostatic
hypertrophy) and CaP (carcinoma prostate) with twenty-five in each category before the serological examination. Serum total
PSA concentration is elevated in 80% of BPH cases while it was elevated in all cases of CaP. With total PSA>10ng/mL, f/t PSA
ratio was not applicable. For TPSTM, a cell proliferation marker these values were 32% and 92% respectively. The advanced cases of CaP were reflected by the
pronounced elevations of PSA and TPStM while f/t PSA ratio was much below the cut-off limit (cut-off limit=0.14). The data suggest that whentotal PSA concentration
<10ng/mL, f/t PSA ratio plays a very important role in discriminating BPH and CaP. However, TPSTM can be used as a valuable adjunct in diagnosis and follow-up of prostate cancer patients, especially in differentiating benign
from malignant cases. 相似文献
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