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Pathogens, especially Gram-negative bacteria or bacterial endotoxin, along with other classical factors, may be involved in
inflammatory response within the aortic endothelium during the progression of cardiovascular disease. Studies have shown that
bacterial endotoxin activates various inflammatory processes in the body. Our study aims to establish a correlation between
endotoxemia and vascular expression of antioxidant enzymes. Swiss albino mice (4 weeks old) were fed a high fat diet for 24
weeks and then were administered Escherichia coli endotoxin intraperitonealy, for 4 weeks. Tissue antioxidant enzymes, serum
levels of IL-6 and TNF alpha were measured from the mice. We report that i.p. administration of endotoxin to hyperlipidemic
mice resulted in elevation of superoxide dismutase and catalase enzymes, which was paralleled by a systemic reduction of serum
cholesterol and LDL expression. Myeloperoxidase levels were also found to be elevated in aortic tissue, while an increase
was also observed in the serum cytokine levels. 相似文献
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