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Biswajit Majumdar Susri Ray Chaudhuri Arun Ray Sandip K Bandyopadhyay 《Indian journal of clinical biochemistry : IJCB》2002,17(1):49-57
Pretreatment of an ethanolic extract of leaf ofPiper betle linn at a dose of 200mg/kg body weight, orally administered to rats for ten consecutive days, was found to possess a significant
protective action against gastric lesions induced by indomethacin. The extract pretreatment resulted in significant increase
in superoxide dismutase (SOD) and catalase (CAT) activity, increase in mucus, hexosamine and total thiol group content, but
marked reduction in oxidatively damaged protein and peroxidised lipid levels as compared to untreated ulcerated control. The
extract was also found to possess both superoxide and hydroxyl free radical scavenging action. The present observations establish
the efficacy of the extract in prevention of experimentally induced peptic ulcer by indomethacin and antioxidant property
appears to be predominantly responsible for such cytoprotective activity in the experimental model. 相似文献
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Joydeep Dutta Chaudhuri 《Anatomical sciences education》2020,13(2):250-271
There has been a fundamental change in health care pedagogy to address the demands and challenges posed by the present generation of millennial students. There is also a growing recognition of the role of intrinsic motivation as a catalyst in a positive learning experience. The term intrinsic motivation refers to energizing behavior that comes from within an individual and develops due to an inherent interest in the activity at hand. However, stimulating intrinsic motivation in the present generation of millennial health care students is a daunting task, considering their diverse and disparate nature. In addition, the inherent generational differences between educators and students, and an increasing emphasis on technological tools have resulted in a dichotomy in the educational environment leading to the development of a greater incidence of burnouts among students. Hence, numerous innovative techniques have been introduced in health care education to enhance the levels of intrinsic motivation in these students. Unfortunately, most of these approaches have only been moderately successful due to their limited ability to address the unique educational expectations of millennial students. The cumulative evidence suggests that specific approaches to stimulate intrinsic motivation should aim at nurturing the learning efforts of students, bridging the generational barriers between educators and students, and ameliorating the stress associated with health care education. Hence, the specific aim of this narrative review is to suggest empirically proven curricular strategies and institutional reforms to enhance intrinsic motivation in health care students belonging to the Millennial Generation. 相似文献
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Information Retrieval from Documents: A Survey 总被引：4，自引：0，他引：4
Given the phenomenal growth in the variety and quantity of data available to users through electronic media, there is a great demand for efficient and effective ways to organize and search through all this information. Besides speech, our principal means of communication is through visual media, and in particular, through documents. In this paper, we provide an update on Doermann's comprehensive survey (1998) of research results in the broad area of document-based information retrieval. The scope of this survey is also somewhat broader, and there is a greater emphasis on relating document image analysis methods to conventional IR methods.Documents are available in a wide variety of formats. Technical papers are often available as ASCII files of clean, correct, text. Other documents may only be available as hardcopies. These documents have to be scanned and stored as images so that they may be processed by a computer. The textual content of these documents may also be extracted and recognized using OCR methods. Our survey covers the broad spectrum of methods that are required to handle different formats like text and images. The core of the paper focuses on methods that manipulate document images directly, and perform various information processing tasks such as retrieval, categorization, and summarization, without attempting to completely recognize the textual content of the document. We start, however, with a brief overview of traditional IR techniques that operate on clean text. We also discuss research dealing with text that is generated by running OCR on document images. Finally, we also briefly touch on the related problem of content-based image retrieval. 相似文献
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Jane Chung Shomir Chaudhuri Thai Le Nai-Ching Chi Hilaire J. Thompson George Demiris 《Educational gerontology》2015,41(12):916-929
Despite the increasing use of health information technologies (HITs) for older adults living in the community and their caregivers, few have been rigorously evaluated for usability by the end users. Think-aloud protocols are a relatively easy method for both clinicians and researchers to use with older adults and those therapists that work with them to provide such an evaluation. In the present report, we provide an exemplar using this method in order to evaluate the usability of a health and wellness technology tool designed for older adults and caregivers. In addition, we discuss methodological and practical considerations for others interested in this approach. The methodology described in this study is easy and practical to undertake, and it can be effectively conducted by researchers and clinicians to find usability issues related to HITs for older adults and their caregivers. 相似文献
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Vitamin B12 being water soluble is excreted in the urine when administered in excess. The probability of finding an abnormally excess
serum concentration would be almost surreal. We report a peculiar clinical situation that may impact the vitamin B12 immunoassay on the Roche Elecsys 2010 due to excess analyte concentration. In separate episodes (Feb and June 2010), the
Biochemistry laboratory of a tertiary-care hospital, Kolkata, India, encountered two critically ill patients with background
chronic kidney disease (CKD), low urine output, and on cyanocoabalamin supplementation, who had serum vitamin B12 concentrations far exceeding expected values; even post dialysis. The B12 assays (pmol/l) were performed using electrochemiluminiscence immunoassay on Roche Elecsys 2010, the assay validity confirmed
by concomitant quality control runs. The immunoassays failed to deliver results, flagged with “signal level below limit”. Biotin therapy was ruled out as a possible interferent. In the first episode, re-assay of a repeat draw yielded same outcome;
outsourcing on Immulite provided concentration of >738 pmol/l. Serial dilution gave result of >29520 pmol/l on Elecsys 2010.
In the second, we gained from past experience. Vitamin B12 concentration >59040 pmol/l was conveyed to the treating nephrologist the very day. The B12 immunoassay on the Elecsys 2010 employs sequential incubation steps for competitive binding that is compromised in the event
of abnormally excess B12 concentration in patient sera akin to the prozone effect. This knowledge may be beneficial while assaying sera of CKD patients
to avoid financial loss due unnecessary repeats and delay in turnaround time. 相似文献
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Supriya Chaudhuri 《国际体育史杂志》2013,30(6):941-955
George Bernard Shaw's early romantic novel about a prizefighter, Cashel Byron's Profession (1882) is possibly the first literary treatment of the risks, compulsions and social hypocrisies surrounding professional sport. It offers a critique of class, work and leisure, of the nineteenth-century bildungsroman, of violence as a spectacle and of the distinction between professional and amateur. In the ‘Preface’ and ‘Note on Modern Prizefighting’, added to the 1901 edition, Shaw provided both a history of prizefighting and a trenchant critique of the public taste for violence which, as he saw it, encouraged the emergence of professional boxing with gloves, under the Queensberry rules, as an even more brutal and dangerous spectacle. Shaw's intimate knowledge of the world of prizefighting, in decline in the 1880s, and his examination of the life of an athlete in a dangerous ‘profession’, open up a critical juncture in the history of modern sport. 相似文献
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Surupa Basu S. Chaudhuri M. Bhattacharyya T. K. Chatterjee S. Todi A. Majumdar 《Indian journal of clinical biochemistry : IJCB》2010,25(2):146-152
This study was conducted to evaluate whether microalbuminuria on admission and after 24 hrs of admission to intensive care
unit (ICU) predicts outcome as well as the Acute Physiology and Chronic Health Evaluation (APACHE) II severity illness score,
the current accepted method of doing so. The study was carried out in a 20 bed mixed medical-surgical ICU of a tertiary care
hospital. Of 525 consecutive adult patients with ICU stay of more than 24 hrs, 238 were included for the study. Patients with
pregnancy, menstruation, anuria, macroscopic hematuria, urinary tract infection, marked proteinuria due to renal and post-renal
structural diseases, were excluded. Spot urine samples were collected on admission to ICU and 24 hrs thereafter. Urine albumincreatinine
ratio (ACR) was measured on ICU admission (ACR1) and after 24 hrs (ACR2) and expressed in mg/g. Patient demographics were
noted on admission. For disease severity scoring, APACHE II scores were calculated. Each patient was followed up throughout
their ICU stay for a maximum of 28 days and the following outcome data were obtained: ICU length of stay and ICU mortality.
Of the 238 patients, 196 survived while 42 patients died in the ICU. Non-survivors had a significantly higher median ACR2
[162.7 mg/g (IQR 69.5–344.3)] in comparison to the survivors who had a median ACR2 = 54.4 mg/g (IQR 19.0–129.1) (P< 0.0001).
The median ACR1 [161.0 mg/g (IQR 29.0–369.3)] of non-survivors was higher than the median ACR1 [80.4 mg/g (IQR 35.1–167.6)]
of survivors but failed to reach statistical significance (P= 0.0948). In a receiver operating characteristic curve (ROC)
analysis, ACR2 emerged as the best indicator of mortality [(area under curve (AUC) of ACR2 = 0.71 > AUC (ACR1) =0.58 > AUC
(ΔACR) =0.55] similar to the currently used APACHE II scores (AUC = 0.78) (P=0.3). At a cutoff of 101 mg/g, ACR2 had a sensitivity
of 69%, specificity of 67%, positive predictive value of 31% and a negative predictive value of 91% for predicting mortality
in the critically ill patients. Absence of significant microalbuminuria at 24 hrs of ICU admission may help to predict survival
in the ICU. 相似文献
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M. Lama M. Chatterjee T. K. Chaudhuri 《Indian journal of clinical biochemistry : IJCB》2013,28(2):197-200
Immunoglobulin (Ig) E has been shown to be a major contributing factor for the development of bronchial hyperresponsiveness in asthma. An elevation in serum IgE levels contributes to asthma and is considered a potent predictor of the development of asthma. The objectives of the present study were to estimate the levels of total serum IgE in asthmatic and healthy control subjects and to investigate the relationship of various demographic and clinical characteristics with the total serum IgE level in asthmatics. We measured the levels of total serum IgE using the ELISA kits (AccuBind, Monobind Inc., USA). The relevant demographic and clinical data were obtained using the questionnaire. The results showed that asthmatic children had significantly elevated level of total serum IgE compared to that of the healthy controls. The levels of total IgE and IL-4 in sera of 44 asthmatic children showed a significant positive correlation. Total serum IgE >150 IU/mL was found to be significantly associated with the age, exposure to cigarette smoke, and raised eosinophil count in asthmatic children. In conclusion, the elevated level of total serum IgE may demonstrate the allergic etiology of asthma in the subjects studied. 相似文献
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Joydeep Dutta Chaudhuri 《Anatomical sciences education》2022,15(5):910-927
It is universally recognized that cadaveric dissection is an essential part of anatomy training. However, it has been reported to induce mental distress in some students and impair their intrinsic motivation (IM) to study. One of the postulated reasons for this behavior is the lack of adequate information and preparation of students for cadaveric dissection. Therefore, it is hypothesized that providing relevant information prior to cadaveric dissection will ameliorate the mental distress, enhance the IM of students, and improve their academic performance. A cohort of occupational therapy students enrolled in an anatomy course were psychologically prepared for cadaveric dissection. Students were provided with a curated list of YouTube videos and peer-reviewed journal articles related to cadaveric dissection prior to the commencement of the anatomy course. All students were also required to attend an oral presentation immediately before commencing dissection. The control group included students who had not been provided with any resources in preparation for cadaveric dissection. Compared to the control group, students who had been prepared demonstrated better quality of cadaveric dissection, improved academic performance, reported less mental distress and greater IM. Moreover, students reported the oral presentation to be most relevant and journal articles to be least useful in their preparation. Therefore, this is an effective approach in the amelioration of mental distress and improvement of performance in anatomy students. Consequently, this study represents a paradigm shift in the pedagogy of anatomy, and could represent a vital element in the evolution of a revitalized anatomy curriculum. 相似文献