Long pentraxin 3 as a marker of COVID-19 severity: evidences and perspectives     

Roberto Assandri  Silvia Accordino  Ciro Canetta  Elisabetta Buscarini  Alessandro Scartabellati  Chiara Tolassi  Federico Serana 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2022,32(2)

IntroductionSeveral laboratory tests are characteristically altered in Coronavirus Disease 2019 (COVID-19), but are not totally accurate in predicting the disease outcome. The long pentraxin 3 (PTX3) is quickly released directly at inflammation sites by many immune cell types. Previous studies have shown that PTX3 correlated with disease severity in various inflammatory conditions. Our study investigated the use of PTX3 as a potential marker of COVID-19 severity and compared its performance in detecting a more severe form of the disease with that of routine laboratory parameters.Materials and methodsStored serum samples of RT-PCR confirmed COVID-19 cases that had been obtained at hospital admission were retrospectively analysed. Intensive care unit (ICU) stay was considered a surrogate endpoint of severe COVID-19. Pentraxin 3 was measured by a commercial enzyme-linked immunosorbent assay.ResultsA total of 96 patients were recruited from May 1st, 2020 to June 30th, 2020; 75/96 were transferred to ICU. Pentraxin 3 was higher in ICU vs non-ICU patients (35.86 vs 10.61 ng/mL, P < 0.001). Univariate and multivariate logistic regression models demonstrated that the only significant laboratory predictor of ICU stay was PTX3 (OR: 1.68 (1.19-2.29), P = 0.003), after controlling for comorbidities. The Receiver Operator Characteristic curve analysis showed that PTX3 had a higher accuracy compared to C-reactive protein (CRP), lactate dehydrogenase (LD), ferritin in identifying ICU patients (AUC of PTX3 = 0.98; CRP = 0.66; LD = 0.70; ferritin = 0.67, P < 0.001). A cut-off of PTX3 > 18 ng/mL yielded a sensitivity of 96% and a specificity of 100% in identifying patients requiring ICU.ConclusionHigh values of PTX3 predict a more severe COVID-19.  相似文献   

Verifying the operation of an elastic crossbar system applied to a panel painting: the Deposition from the Cross by an anonymous artist from Abruzzo,sixteenth century     

Linda Cocchi  Bertrand Marcon  Giacomo Goli  Paola Mazzanti  Ciro Castelli  Andrea Santacesaria 《文物保护研究》2017,62(3):150-161

This study deals with the post-treatment evaluation of the elastic crossbar system already designed and installed on the recently restored panel painting Deposition from the Cross by an anonymous artist from Abruzzo (sixteenth century). After the restoration, the panel and the crossbars were subjected to mechanical tests to identify their elastic characteristics. Then the panel, equipped with the elastic crossbar system, was subjected for about two months to controlled environmental cycles made up of approximately constant humidity periods. During the two months, the forces exerted by the springs and the deformations of both panel and crossbars were continuously monitored. A mathematical model, calibrated on the specific parameters derived from the analysis of the panel, provided the deformation that the panel would have shown without the crossbars; comparing the model output with the measured data provided a restraining effect (RE) of approximately 7% (RE could range between zero – no restraint – and 100% – total restraint). Future developments of this project will define appropriate procedures to design an elastic crossbar system for a given panel, once the expert judgement of restorers has identified the most desirable RE to be achieved.  相似文献   

Experimental validation of a continuous-time MCSI algorithm with bounded adaptive gains     

Umberto Montanaro  Ramon Costa-Castelló  Josep M. Olm  Ciro Larco Barros 《Journal of The Franklin Institute》2019,356(12):5881-5897

Model reference adaptive control algorithms with minimal controller synthesis have proven to be an effective solution to tame the behaviour of linear systems subject to unknown or time-varying parameters, unmodelled dynamics and disturbances. However, a major drawback of the technique is that the adaptive control gains might exhibit an unbounded behaviour when facing bounded disturbances. Recently, a minimal controller synthesis algorithm with an integral part and either parameter projection or σ-modification strategies was proposed to guarantee boundedness of the adaptive gains. In this article, these controllers are experimentally validated for the first time by using an electro-mechanical system subject to significant rapidly varying disturbances and parametric uncertainty. Experimental results confirm the effectiveness of the modified minimal controller synthesis methods to keep the adaptive control gains bounded while providing, at the same time, tracking performances similar to that of the original algorithm.  相似文献   

Increased shoe bending stiffness increases sprint performance     

Stefanyshyn D  Fusco C 《Sports biomechanics / International Society of Biomechanics in Sports》2004,3(1):55-66

The purposes of this investigation were to determine if increasing the bending stiffness of sprint shoes increases sprinting performance and to determine whether simple anthropometric factors can be used to predict shoe bending stiffness for optimal performance. Thirty-four athletes were tested using four different shoe conditions--a standard condition consisting of their currently used footwear and three conditions where the bending stiffness was increased systematically. The sprinters performed maximal effort 40 m sprints and their sprint times were recorded from 20 to 40 m. On average, increasing the shoe bending stiffness increased sprint performance. The stiffness each athlete required for his or her maximal performance was subject specific but was not related to subject mass, height, shoe size or skill level. It is speculated that individual differences in the force-length and force-velocity relationships of the calf muscles may influence the appropriate shoe stiffness for each athlete to obtain their maximal performance.  相似文献   

Analysis of the body composition of Paralympic athletes: Comparison of two methods     

Valdir De Aquino Lemos  Eduardo Da Silva Alves  Paulo Adriano Schwingel  João Paulo Pereira Rosa  Andressa Da Silva  Ciro Winckler 《European Journal of Sport Science》2016,16(8):955-964

Body composition is a physiological variable associated with physical activity and, in some cases, is related to athletic performance. Our objectives were to describe the body composition of participants in three distinct Paralympic sports and to compare the values of body density and estimated body fat obtained from the Paralympic athletes on the National Team by air-displacement plethysmography (ADP) and by the anthropometric method (skinfolds (SFs)). The sample consisted of 70 volunteers of both genders. The body composition of the volunteers was evaluated using the ADP in a Bod Pod^® and seven SFs. There were no significant differences between the values obtained by ADP and SF for body fat percentage (p?=?.58) and body density (p?=?.49). Analysis by Bland–Altman plots showed mean differences of 0.56?±?4.94 (?9.12–10.23) and ?0.0017?±?0.0113 (?0.024–0.020) for body fat percentage and body density, respectively. In conclusion, body composition analyses of Paralympic athletes by the ADP and SF methods show similar results, and ADP should be used as the first option when available. When the use of ADP is not possible, estimating body density and fat percentage by SF is a viable alternative for Paralympic athletes when future comparisons will use the same analysis method.  相似文献