排序方式： 共有15条查询结果，搜索用时 15 毫秒
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Miguel Á. Conde Francisco J. García-Peñalvo María J. Rodríguez-Conde Marc Alier María J. Casany Jordi Piguillem 《Interactive Learning Environments》2014,22(2):188-204
The tools used in learning processes are in a continuous state of flux. One of the most significant changes is the application of Information and Communications technologies (ICTs) to educational contexts. This provides new possible ways to carry out learning activities, new learning services, the possibility to use new kinds of contents and activities, etc. However, ICTs have not provided as many advantages as they were supposed to, so changes are necessary. In this context, a new set of tools, Web 2.0, offers a new way to understand the Web, in which the user is the centre. Further, users can cooperate in order to define contents. This concept is also applied in technology-mediated learning but there are important problems when one tries to integrate such tools and concepts with existing systems. This paper explores the integration of these tools in traditional learning environments, the various possibilities and their advantages and drawbacks. After that, an interoperability scenario is described and two experiences are presented to show how 2.0 tools can be integrated in learning activities, and its effect in educational process. 相似文献
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Grace Shum Angeles Conde Carmen Díaz Francisco Martínez Lorenzo Molina 《Cultura y Educación》2013,25(5):69-79
La incidencia de las competencias lingüistícas del escolar sobre las adquisiciones escolares en las demás áreas del currículum es una realidad que todos los maestros pueden comprobar día a día. En este trabajo se investiga esa incidencia, medida a través de la variable fracaso escolar, y sus resultados podrían permitir extraer algunos principios de intervención educativa precoz en algunos aspectos del lenguaje cruciales para la escolaridad posterior. 相似文献
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It is known that the conductance of nanochannels as a function of electrolyte concentration deviates from a linearly proportional relationship and approaches a value independent of the concentration as the electrolyte concentration is lowered. Most of the proposed models account for this behavior by considering a constant surface charge density and an ideal electrolyte solution. However, at low electrolyte concentrations, the ideal electrolyte approximation is no longer valid because the ions that result from the atmospheric carbon dioxide dissolution in water dominate the ionic concentration. In this paper, arrays of silica nanochannels were electrically characterized via conductance measurements. The conductance at low salt concentrations is modeled by a variable surface charge model that accounts for all ionic species in solution. This model was used to determine the variable surface charge of the bare silica nanochannels as well as of chemically modified nanochannels. The model correctly predicted the variation of the nanochannel conductance observed after silane (aminopropyldimethylethoxysilane) functionalization and single-strand DNA immobilization. Finally, pH modification of bulk KCl solutions was employed as an alternative method of changing the surface charge of silica nanochannels. Surface charge calculated from conductance measurements performed at different bulk pH values confirmed that the surface charge of the silica nanochannel walls is sensitive to the H+ concentration. 相似文献
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High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment 总被引：1，自引：0，他引：1
Microfluidics is an emerging technology which allows the miniaturization, integration, and automation of fluid handling processes. Microfluidic systems offer low sample consumption, significantly reduced processing time, and the prospect of massive parallelization. A microfluidic platform was developed for the control of the soluble cellular microenvironment of Saccharomyces cerevisiae cells, which enabled high-throughput monitoring of the controlled expression of alpha-synuclein (aSyn), a protein involved in Parkinson's disease. Y-shaped structures were fabricated using particle desorption mass spectrometry-based soft-lithography techniques to generate biomolecular gradients along a microchannel. Cell traps integrated along the microchannel allowed the positioning and monitoring of cells in precise locations, where different, well-controlled chemical environments were established. S. cerevisiae cells genetically engineered to encode the fusion protein aSyn-GFP (green fluorescent protein) under the control of GAL1, a galactose inducible promoter, were loaded in the microfluidic structure. A galactose concentration gradient was established in the channel and a time-dependent aSyn-GFP expression was obtained as a function of the positioning of cells along the galactose gradient. Our results demonstrate the applicability of this microfluidic platform to the spatiotemporal control of cellular microenvironment and open a range of possibilities for the study of cellular processes based on single-cell analysis. 相似文献
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L Maïmoun D Mariano-Goulart I Couret J Manetta E Peruchon JP Micallef 《Journal of sports sciences》2013,31(9):875-883
Sports characterized by little or moderate weight bearing or impact have a low osteogenic effect. However, the action of such sports on bone turnover remains unclear. The objective of this study was to determine the effect on bone remodelling of physical activities that induce moderate external loading on the skeleton. Thirty-eight male athletes aged 18–39 years (cyclists, n?=?11; swimmers, n?=?13; triathletes, n?=?14) and 10 age-matched sedentary controls aged 22–35 years participated in the study. The study combined measurement of bone mineral density by dual-energy X-ray absorptiometry and bone turnover assessment from specific biochemical markers: serum bone-specific alkaline phosphatase, osteocalcin, urinary type I collagen C-telopeptide and calcium. Compared with the controls and swimmers, adjusted bone mineral density was higher (P?<?0.05) in triathletes at the total proximal femur and lower limbs. No differences in bone mineral density were found between cyclists, swimmers and controls. Compared with controls, osteocalcin was higher (P?<?0.05) in triathletes and swimmers and urinary type I collagen C-telopeptide was higher in swimmers only. Serum bone-specific alkaline phosphatase was lower (P?<?0.05) in cyclists than in all other groups. In conclusion, an osteogenic effect was found only in triathletes, mainly at bone sites under high mechanical stress. Bone turnover differed in athletes compared with controls, suggesting that bone turnover may be sport-practice dependent. Despite some encouraging observations, it was not possible to show that changes in the bone remodelling process were sport-discipline dependent. 相似文献
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ResumenLos datos lingüísticos fueron registrados mediante un vídeo en un contexto natural y habitual del niño. Se analiza el lenguaje desde los tres planos lingüísticos, sintáctico, semántico y pragmático. Además, para observar el nivel de desarrollo lingüístico, se comparó la producción del lenguaje del sujeto estudiado con la de otro niño cuyo desarrollo es adecuado.Tras los resultados obtenidos del trabajo, se puede concluir que los factores externos, en los aspectos que están relacionados a pautas de cuidado y de interacción diádica adulto-niño, son fundamentales para la adecuada adquisición y desarrollo lingüístico y, además, la rehabilitación del mismo no es muy esperanzadora. 相似文献
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《野草》主题的佛学解读 总被引：2，自引：0，他引：2
孟宏峰 《内蒙古师范大学学报(哲学社会科学版)》2005,34(3):97-101
《野草》主题隐含着一个与佛学苦、空观相吻合的逻辑层次。在现世苦难的打击下,鲁迅常常觉得唯“黑暗与虚无”乃是“实有”,佛学无常无我价值观促使他走向“绝望之为虚妄,正与希望相同”的空无状态。由空开拓出生命的抗争之路,承担起现世世界扫滞除执、反抗绝望的责任是《野草》哲学的关键。诗文吸收佛教勇猛精进的精神,同时消解了佛教因果轮回的唯心思想。 相似文献
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Antonio González Ángeles Conde Pino Díaz Mar García Carmen Ricoy 《Higher Education》2018,75(4):625-642
Instructors’ teaching styles in higher education are an issue of major importance because these interactions affect students’ self-perceptions, involvement, and achievement. This study aimed to test a theoretical model of relations between perceived teaching styles (autonomy support, structure, and control) and competences, self-efficacy, and commitment in pre-service teachers; to assess the invariance of the model in two samples; and to analyze the mediated relations between these variables. Measures were collected from 842 Spanish pre-service teachers. As main research implications, teaching styles predicted acquired competences, competences predicted teaching self-efficacy, and self-efficacy predicted commitment to the profession. This model was equivalent in two samples of childhood and primary education pre-service teachers. Competences and self-efficacy mediated the relationships between variables. As practical implications, this study clearly shows the need for different interventions to enhance adequate instructors’ teaching styles and to foster among novice pre-service teachers the acquisition of professional competences, initial self-efficacy, and a good level of commitment to their profession. 相似文献
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ResumenEn el ámbito de estudio de la adquisición del lenguaje, la deixis se presenta como un tema importante. Se trata de un recurso lingüístico básico para el desarrollo de la comunicación, por medio del cual los interlocutores se ubican en el espacio y el tiempo estableciendo relaciones entre ellos y con los objetos, al mismo tiempo que se identifican en los roles conversacionales. Asimismo constituye una rica fuente de datos ya que su aprendizaje implica, a la vez, cierto nivel de desarrollo comunicativo, cognitivo y lingüístico, suponiendo un largo y difícil camino que el niño tiene que recorrer basta lograr su dominio. En el presente trabajo pretendemos estudiar la evolución de los términos deícticos en sus diferentes manifestaciones (persona, espacio, tiempo, modo y verbo) en niños españoles. Se realizó un estudio longitudinal, desde una perspectiva funcional, con dos niñas que contaban dos años al comienzo del estudio, finalizándolo cuando cumplieron tres años, y que procedían de medios ambientales diferentes. A partir del análisis de las muestras de habla espontánea de ambas niñas, recogidas en su contexto habitual, se observó el uso que éstas hacen de los términos deícticos. Además, se tuvo en cuenta la adecuación de dicha utilización al contexto comunicativo, señalando, al mismo tiempo, las implicaciones de dicho uso en la evolución y posterior conocimiento de estos términos; así como las diferencias en relación al medio de procedencia de ambos sujetos. 相似文献