Prioritization of intellectual capital indicators in knowledge-based industries: Evidence from pharmaceutical industry     

Gholamhossein Mehralian  Hamid Reza Rasekh  Peyman Akhavan  Ali Rajabzadeh Ghatari 《International Journal of Information Management》2013

During the last decade, intellectual capital (IC) and intangible assets have been widely considered as critical tool to deliver successful business in an intensive-knowledge environment. Accordingly, the main goal of this paper is therefore to develop and prioritize the most important indicators of intellectual capital in knowledge-based industries. Based on an extensive literature review, a valid and reliable questionnaire was designed. In order to data gathering, it was sent out to participants from both academic and university who qualified well in pharmaceutical practice. In order to exact prioritization of indicators, fuzzy TOPSIS technique as a MADM model was used. The fuzzy TOPSIS results revealed participants remark high concerns especially about knowledge and skills of managers and employees regarding to human capital, high concerns particularly about positive climate, ratio of investment in R&D and numbers of R&D projects according to structural capital, while considering the relational capital, more attention was paid to customers and strategic cooperation such as alliances and licensing.  相似文献   

In Vitro Evaluation of the Efficacy of Liposomal and Pegylated Liposomal Hydroxyurea     

Seyed Ebrahim Alavi  Maedeh Koohi Moftakhari Esfahani  Soheil Ghassemi  Azim Akbarzadeh  Gholamhossein Hassanshahi 《Indian journal of clinical biochemistry : IJCB》2014,29(1):84-88

Breast cancer is one of the most frequent cancer types within women population. Hydroxyurea (HU) is a chemotherapy compound for treatment of patients with cancer diagnosis, including breast cancer associated with several adverse effects. In this study, we applied nanotechnology to decreased drug side effects along with improvement of therapeutic index. Liposomation is widely used in modern pharmacological developments in order to enhance the effects of the drugs. To achieve this, in this study a mixture of phosphatidylcholine and cholesterol was made up and HU was added to the resultant mixture, was then pegylated using Polyethylene Glycol 2000 to increase resistance, applicability and solubility. The mean diameters of nanoliposomal and pegylated nanoliposomal HU were measured by Zeta sizer device and obtained about 402.5 and 338.2 nm. The efficiency of non-pegylated and pegylated liposomal HU was 70.8 and 64.2, respectively. Releasing HU in both formulations was estimated about 25.8 and 21.7 %. Also, this study investigated the cytotoxicity effect of nanoliposomal and pegylated nanoliposomal HU using MTT assay. Results of this investigation showed that the cytotoxic properties of pegylated HU was 3.6 % more than those non-pegylated form, while was 38.93 % more than ordinary from of HU. This study showed that the stability, releasing pattern and cytotoxicity of the pegylated nanoliposomal HU is better than that of nanoliposomal HU.  相似文献