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1.
Iron deficiency evolves, slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non heme iron (44%) in the 7 days old pups born to iron deficient mothers. The hemoglobin
levels and PCV (packed cell volume) were significantly reduced only after the age of three weeks. The activities of GABA (γ-amino
butyric acid) shunt enzymes viz. GDH, GAD and GABA-T (glutamate dehydrogenase, glutamate decarboxylase and GABA-transaminase,
respectively) and GABA content were found to decrease during gestation and/or lactation iron deficiency at 1 week (wk), 2wk,
3wk and 4wk of age in the developing rat brains. However GABA binding showed a significant increase at different age groups.
The iron deficiency during lactational exposure showed significant alteration in most of the parameters only at the age of
3 weeks onwards. On rehabilitation with iron supplemented diet for 2 weeks, these altered parameters could not attain corresponding
control values. A prolonged iron deficiency causing alterations in GABA may lead to neurological and behavioral alterations. 相似文献
2.
Iron deficiency evolves slowly through several stages. Early iron deficiency caused a depletion in iron stores as shown by
a reduction in the levels of hepatic non-heme iron in the new born of iron deficient mothers. Of particular importance is
the effect on central nervous system, which leads to the defects in the cognition and learning processes in humans. Evidence
is strong that in many under developed countries iron deficiency is the main cause of anaemia and supplementation under trial
conditions may prevent some defects of iron deficiency but not all. 相似文献
3.
HS Batra Ashwini Kumar TK Saha Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2015,30(2):230-233
To establish utility of single enzymatic marker for the diagnosis of acute pancreatitis. This is a cohort study. Tertiary care centre proven cases of acute pancreatitis (n = 50) admitted in surgery ward between December 2011 and May 2013 were included in the study. Serum amylase and lipase were performed along with many analytes. All relevant data including serum lab values and imaging were collected. All 50 patients included in the study had raised serum lipase, 42 patients had both amylase and lipase raised, 8 patients had amylase normal but lipase raised. In smaller hospitals where limited lab and radiological facilities are available, estimation of serum lipase will be a better choice over serum amylase in diagnosis of acute pancreatitis. 相似文献
4.
The Covid-19 pandemic has made visible the sharp economic, health, caste-based, gender, and educational inequalities that the disadvantaged face in India. Curriculum is ordinarily viewed as a tool for regulating and adapting modern educational systems to society’s needs and trends. But most governments have been unwilling to rethink post-pandemic education, despite the loss of livelihoods, food, and shelter – accentuated by educational inequality and institutionalised via neoliberal reforms. The current pandemic compels us to examine the meanings and purposes of education from a socio-historical perspective, to understand how questions of equity and justice, rooted in India’s Constitution, can be woven into curricula and pedagogic approaches. This article reflects on the role that curriculum can play in enabling an ecologically and socially just and connected world. This curricular response includes cognising the significance of subaltern disciplines and imagining transformative pedagogies that can help reclaim education spaces and sustain epistemic justice.
相似文献5.
With ever increasing information being available to the end users, search engines have become the most powerful tools for obtaining useful information scattered on the Web. However, it is very common that even most renowned search engines return result sets with not so useful pages to the user. Research on semantic search aims to improve traditional information search and retrieval methods where the basic relevance criteria rely primarily on the presence of query keywords within the returned pages. This work is an attempt to explore different relevancy ranking approaches based on semantics which are considered appropriate for the retrieval of relevant information. In this paper, various pilot projects and their corresponding outcomes have been investigated based on methodologies adopted and their most distinctive characteristics towards ranking. An overview of selected approaches and their comparison by means of the classification criteria has been presented. With the help of this comparison, some common concepts and outstanding features have been identified. 相似文献
6.
Mohit Kumar Gangania Jyoti Batra Suman Kushwaha Rachna Agarwal 《Indian journal of clinical biochemistry : IJCB》2017,32(3):353-356
Parkinson’s disease (PD) is an old age disorder of basal ganglia which involves oligomerization of α-synuclein protein and formation of intercellular inclusions known as “Lewy bodies” in substantia nigra and caudate nuclei in brain which is progressive in nature. It is second most prevalent neurodegenerative disorder characterized by tremor at rest, muscle rigidity, slowness of movement (bradykinesia, akinesia), and changes in posture (instability). Both excess and deficiency in levels of transition metals (especially iron, copper) can be detrimental to the central nervous system. Abnormalities in iron (Fe) and copper (Cu) metabolism have been reported to produce oxidative stress which is one of the major cause in pathogenesis of PD. In the present study 35 PD patients and 33 controls of Northern Indian population were included and serum levels of Fe, Cu and ceruloplasmin (Cp) were measured. Serum Fe (p < 0.01) and Cu (p < 0.01) levels were found to be significantly decreased in PD, whereas there was no significant change in Cp levels in PD patients as compared to controls. These results suggest the existence of a defect in iron which over the time, may hasten the entry of iron into the brain and decrease iron in the extracellular compartment in PD patients. 相似文献
7.
T. K. Saha Arabinda Mohan Bhattarai H. S. Batra Mithu Banerjee Pratibha Misra Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2015,30(3):271-274
Increase in urine albumin excretion rate (AER) precede a fall in glomerular
filtration rate in patients developing diabetic chronic kidney disease (CKD). Our
results have shown that 7 (50 %) of diabetic and hypertensive individuals with
decreased GFR do not have increased AER. In this cross-sectional study, we measured
AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric
method. We correlated the results with eGFR values obtained by Cockcroft–Gault and
MDRD method. The method used was not a compensated method. We measured serum
creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of
data showed positive correlation between eGFR and microalbuminuria by both the
methods with eGFR <60 mL/min/1.73 m2. Pearson’s
correlation co-efficient (r) was 0.9 (p = 0.0001)
by Cockcroft–Gault formula and 0.69 (p = 0.0063)
by MDRD formula. Our results concluded that there was positive correlation between
AER and eGFR <60 mL/min/1.73 m2. We have recognized
that these two parameters provide a complimentary benefit in management of cases
with CKD. 相似文献
8.
A. P. S. Narang S. Batra S. Sabharwal S. C. Ahuja 《Indian journal of clinical biochemistry : IJCB》2004,19(2):111-113
In the present study primary involution osteoporosis and vitamin D levels were studied in 60 subjects including thirty controls.
The biochemical analysis of serum calcium, phosphorus, ALP, albumin and vitamin D3 (1,25-(OH)2 D3) levels were significantly decreased in osteoporotic patients when compared to non-osteoporotic control group. There was
a significant correlation of magnitude of sun exposure with 1,25-(OH)2 D3 levels. Similarly, vitamin D intake in the diet has a significant correlation with 1,25-(OH)2 D3 concentration. However, no correlation could be obtained between vitamin D3 levels with increasing age. Among the biochemical markers serum calcium, phosphorus, ALP and albumin could not be correlated
with 1,25-(OH)2 D3 levels. 相似文献
9.
Hitender Singh Batra Parduman Singh Babu Lal Somani Ashish Gupta Sangeetha Sampath Vivek Ambade 《Indian journal of clinical biochemistry : IJCB》2007,22(2):106-108
Serum ferroxidase and albumin levels were determined in 98 patients of tubercuiosis, of whom 49 were freshly diagnosed, sputum
positive (group-I) & 49 were completely treated patients (group-II). Forty nine age and sex matched healthy individuals were
taken as controls. Mean±SD of serum ferroxidase and albumin levels in controls, group-I and group-II was found to be 864.35±106.35
IU/L & 3.91±0.234 g/dL, 1603.76±222.65 IU/L & 3.24±0.518 g/dL and 1001.78±201.63 IU/L & 3.82±0.43 g/dL, respectively. Serum
ferroxidase in group I was significantly higher as compared to controls and group-II (p<0.01). The decreased levels of serum
albumin in group I, as compared to control and group-II was statistically significant (p<0.01). Serum ferroxidase: albumin
ratio (Ferroxidase in International Unit per gram of albumin) in group I (50.47±10.36 IU/g) was significantly higher than
controls (22.22±3.3 IU/g), (p<0.001) while in group II it was significantly lower (26.72±7.18 IU/g, p<0.001) than group-I
and close to control values. Serum ferroxidase: albumin ratio (IU/g) can therefore be incorporated as a surrogate marker to
assist in diagnosis and prognosis of pulmonary tuberculosis. 相似文献
10.
Ellen M. Robertson Sara M. Allison Caroline M. Mueller Andrew C. Ferriby Alex R. Roth Ranjan Batra 《Anatomical sciences education》2024,17(1):147-156
Brain dissection is typically an important part of teaching neuroscience in health professional programs. This results in the need to effectively remove brains, which is often performed in a gross anatomy laboratory in the same curriculum. The aim of this study was to determine the most effective method of brain removal based on the time required for removal, difficulty of removal, and preservation of key brain structures for educational purposes. Six different dissectors performed each of the three calvaria removal approaches and three different spinal cord transection methods rating them for difficulty and tracking the time required. The combination of calvaria and brainstem approaches and the order of completion was randomized to control for fatigue and previous individual experience. After all brains were removed, each was evaluated by neuroscience faculty for utility in education contexts. The study found little difference between the individual approaches for both calvaria removal and spinal cord transection in regards to quality of outcome. The use of a circumferential cut only proved to be the most time-effective method for calvaria removal while a posterior cut between C1 and C2 was the most time-effective and least difficult method for brainstem release. There was no one technique that proved to be most beneficial across all three measures. However, different approaches resulted in a different combination of benefits across the time, difficulty, and outcome ratings that should be considered in light of the individual needs of any program or researcher. 相似文献