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The term noise is used to describe fluctuations about the mean deterministic stationary value of a physical quantity. It is
now being increasingly realised that noise is an important ingredient to bring order in dynamical processes. Though it appears
counterintuitive, noise seems to help in directing transport processes in biological systems at the molecular level. In Part
2 of the article, we discuss some more examples of noise assisted directed motion. 相似文献
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Noise affects most of the activities. The term noise is used to describe fluctuations about the mean deterministic stationary value of a physical quantity. Noise is generally associated, for example, with inaccuracies in measurements or impurities in signals such as musical notes and hence is undesirable. However, its essential role in physical processes was pointed out in the beginning the last century by Smoluchowski and others. It is only in the last two decades or so that the positive (active) aspects of its role has come to light and is being subjected to intense scrutiny. It is now being increasingly realised that noise is an important ingredient to bring order in dynamical processes. Though it appears counterintuitive, noise seems to help in directing transport processes in biological systems at the molecular level. 相似文献
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Seema Bhargava Khageshwar Mahato Anjali Manocha Mamta Kankra Parul Singla Anisha Sharma Ashok Ahirwar Vinod Gupta Salamma Jose 《Indian journal of clinical biochemistry : IJCB》2021,36(3):360
HbA1c is used extensively for the diagnosis and management of diabetes mellitus. It constitutes 80% of glycated HbA1(Glycated haemoglobin(GHb)A), and depends upon blood glucose and RBC life span. RBC life span varies with anemia, leading to a consequent alteration in the HbA1c value irrespective of the circulating blood glucose concentration. But to the best of our knowledge no Hb cut offs have been derived for appropriate interpretation of HbA1c. The prevalence of anemia in Indian population is nearly 40% as per its definition by WHO—Hb < 12 g/dL in females and < 13 g/dL in males—with most cases attributable to nutritional deficiencies. Hence, we aimed to identify Hb cut-off for accurate interpretation of HbA1c in presence of deficiency anemias. Partial correlation between random blood glucose (RBG) and HbA1c was studied in 1312 subjects, 470 of whom had deficiency-related anemia]. The data was adjusted for age, sex and Hb. Partial correlation between RBG and HbA1c was highly significant (p < 0.0001) till Hb of 8.1 gm/dL. Significance reduced to p = 0.003 and p = 0.006 as the cut off of Hb reduced to 7.1 gm/dL and 5.0 gm/dL, respectively, but was not lost. Hence, caution in interpretation of HbA1c is not required till an Hb of 5 g/dL. 相似文献
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