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Every individual should be entrusted with an internal driver to strive their best towards achieving their potential and to manifest their performance through innovative means. This can be reached only under circumstances where the abstract human values and principles are recognized and indoctrinated in the culture. The strategies discussed in this article will serve as input in proposing the areas of focus toward the practice of human governance. 相似文献
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Y. P. Singh O. P. Sachdeva S. K. Aggarwal K. Chugh Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2008,23(3):290-292
Blood glutathione was estimated in fifty patients of head and neck cancer in the age group of 18–76 years and the results
were compared with a group of normal healthy controls. Mean blood glutathione level was found to be significantly lowered
in patients than the controls. Irrespective of the site, TNM classification, histopathology, and character of lesion, fall
in blood glutathione was nearly same in all the patients. The mean level was significantly increased after radiotherapy when
compared with the levels before radiotherapy. The decreased levels of GSH in-patients with head and neck cancer, observed
in the present study, may be due to its increased utilization by the cells. The results suggest that patients with head and
neck cancer have increased oxidative stress. 相似文献
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Anshita Aggarwal Sant Ram Abhilasha Garg Rimesh Pal Anil Bhansali Priyanka Singh Sadhna Sharma J. S. Thakur Naresh Sachdeva Sanjay Kumar Bhadada 《Indian journal of clinical biochemistry : IJCB》2021,36(1):67
We aimed to estimate metabolic bone profile in a large cohort of healthy, adult Indian population to generate reference standards of serum calcium, phosphate and alkaline phosphatase (ALP), 25 (OH) Vitamin D and iPTH, and also to find out the prevalence of Vitamin D deficiency in healthy population. Apparently healthy people in the age group of 20–80 years, residing in the union territory of Chandigarh were chosen. Fasting samples for serum calcium, phosphate, albumin, alkaline phosphatase (ALP), 25 (OH) D and iPTH were collected and were processed on the same day. We recruited 930 healthy subjects from different subsectors of Chandigarh. Final analysis was done for 915 subjects. Out of this, 530 (58%) were women and 385 (42%) were men. The study participants were divided into two groups, less than and more than 50 years for the men and pre and post-menopausal for the women. The serum calcium, phosphate, ALP and iPTH were significantly higher in the post-menopausal women compared to the pre-menopausal women. The median plasma 25 (OH) D in men and women was 12.5 ng/mL and 14.3 ng/mL, respectively. 25 (OH) D deficiency was seen in 65.4% of individuals. 25 (OH) D levels co-related negatively with iPTH levels (r = − 0.4, p < 0.0001), and showed an increasing trend with age. We have thus presented metabolic bone profile of healthy, adult north Indian population. These reference values can be used for diagnosis and monitoring of various MBDs. Vitamin D deficiency is still rampant in our population in spite of increasing awareness. 相似文献
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Brain type natriuretic peptide (BNP)—A marker of new millennium in diagnosis of congestive heart failure 总被引：1，自引：0，他引：1
Arun Raizada Suman Bhandari Muzaiyan Ahmed Khan Harsh Vardhan Singh Sherin Thomas Vikram Sarabhai Neelima Singh Naresh Trehan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):4-9
The burden of disease in patients with congestive heart failure is high. The future of BNP looks promising as it may be a
better diagnostic tool for the diagnosis of CHF in developing countries in new millennium. Natriuretic peptide hormones, a
family of vasoactive peptides with many favourable physiological properties, have emerged as important contenders for development
of diagnostic tools and therapeutic agents in cardiovascular disease. Measurement of B-type natriuretic peptide has become
as an easy-to-perform bedside test. The clinical and diagnostic significance of the measurement of plasma Nt-proBNP in the
diseases of the cardiovascular system with particular emphasis on the assessment of patients with heart failure and their
effects on predicting survival rate. The plasma levels of Nt-proBrain Natriuretic peptide responds more vigorously after myocardial
infarction than those of other natriuretic peptides. This article is an attempt to give a short overview on the utility of
BNP-blood levels for the diagnosis and treatment of heart failure 相似文献
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The research reported in this article investigated the effect of manufacturing strategy on organizational performance in the Malaysian electrical and electronic sector. It was revealed that a cost‐based strategy greatly affected the performance of organizations participating in this study. This result implied that a cost‐based strategy is still a dominant concern for manufacturing firms. The information gathered through this study is useful for strategy formulation and for understanding how a strategy can lead to improved organizational performance in general. 相似文献
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S. V. Rana Aastha Malik Sanjay K. Bhadada Naresh Sachdeva Rajesh Kumar Morya Gaurav Sharma 《Indian journal of clinical biochemistry : IJCB》2017,32(1):84-89
Type 2 diabetes mellitus consists of dysfunctions characterized by hyperglycemia and resulting from combination of resistance to insulin action and inadequate insulin secretion. Most of diabetic patients report significant gastrointestinal symptoms. Entire GI tract can be affected by diabetes from oral cavity to large bowel and anorectal region. Proteins, carbohydrates, fats, and most fluids are absorbed in small intestine. Malabsorption may occurs when proper absorption of nutrients does not take place due to bacterial overgrowth or altered gut motility. The present study was planned to measure various malabsorption parameters in type 2 diabetic patients. 175 patients and 175 age and sex matched healthy controls attending Endocrinology Clinic in PGI, Chandigarh were enrolled. Lactose intolerance was measured by using non-invasive lactose hydrogen breath test. Urinary d-xylose and fecal fat were estimated using standard methods. Orocecal transit time and small intestinal bacterial overgrowth were measured using non-invasive lactulose and glucose breath test respectively. Out of 175 diabetic patients enrolled, 87 were males while among 175 healthy subjects 88 were males. SIBO was observed in 14.8 % type 2 diabetic patients and in 2.8 % of controls. There was statistically significant increase (p < 0.002) in OCTT in type 2 diabetic patients compared with controls. OCTT was observed to be more delayed (p < 0.003) in patients who were found to have SIBO than in patients without SIBO. Lactose intolerance was observed in 60 % diabetic patients and 39.4 % in controls. Urinary d-xylose levels were also lower in case of diabetic patients but no significant difference was found in 72 h fecal fat excretion among diabetic patients and controls. Urinary d-xylose and lactose intolerance in SIBO positive type 2 diabetic patients was more severe as compared to SIBO negative diabetic patients. From this study we can conclude that delayed OCTT may have led to SIBO which may have instigated the process of malabsorption among type 2 diabetic patients. 相似文献
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Ashuma Sachdeva Shashi Seth Anju Huria Khosla Sumit Sachdeva 《Indian journal of clinical biochemistry : IJCB》2005,20(1):131-134
Markers of bone formation in serum include total and bone specific alkaline phosphatase, osteocalcin and Type 1 collagen carboxy
terminal extension peptide. Bone resorption can be assessed by measuring plasma tartarate resistant acid phosphtase and urinary
excretion of collagen degradation products: hydroxyproline, hydroxylysine glycosides and more recently the pyridinium crosslinks
and associated peptides. We compared the excretion of hydroxyproline in women of reproductive age group to those of menopausal
age group and found a significant difference in the two age groups. Urinary hydroxyproline was found to be significantly raised
in post menopausal women. Thus hydroxyproline maybe used as the earliest indicator in the prognostic assessment of postmenopausal
women of their risk of developing osteoporosis and fracture. 相似文献
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