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Arun Kumar B. S. Dhillon D. N. Rao Geetha Menon Hari Shankar L. K. Dhaliwal Maiti Leema Nomita Chandhiok Neeta Kumar Rohini Sehgal Suneeta Mittal Sumitu Sahdev Kandpal Shobha V. L. Jindal 《Indian journal of clinical biochemistry : IJCB》2012,27(4):405-409
Malondialdehyde (MDA) is widely used as oxidative stress biomarker in biomedical research. Plasma is stored in deep freezers generally till analysis. Effect of such storage on MDA values, which may be variable and prolong, was incidentally observed in the ongoing study which is to estimate oxidative stress with oral iron. Plasma from blood samples of pregnant women (20–30 years age) in third trimester of singleton pregnancy (n = 139), consuming oral iron tablets was stored at −20 °C with intention of MDA estimation, as soon as possible. However logistic problems led this storage for prolonged and variable period (1–708 days). When values of MDA estimated using “Ohkawa” 79 method and readings were plotted against time to check the temporal effect, it showed a hyperbolic curve. Standard deviation (SD) was lowest when samples were tested within 3 weeks time. The samples analyzed within 3 weeks had mean ± SD value of 31.59 ± 26.11 μmol/L, while 123.7 ± 93.97 and 366.5 ± 189.8 μmol/L for samples stored for 1–3 and 4 months to 1 year respectively. Mean ± SD were 539.9 ± 196.8 in the samples store for more than a year. Rate of change in values was also lowest (0.0433 μmol/L/day) in the samples tested within first 3 weeks, which rose to 1.2 μmol/L/day during 3 month’s storage. This rate peaked at storage of 120 days (1.87 μmol/L/day) and fell to 0.502 μmol/L/day in the second year of storage. It is concluded that at −20 °C, only 3 weeks of storage time should be considered valid for fairly acceptable stability in MDA values. 相似文献
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Boada Richard Willcutt Erik G. Tunick Rachel A. Chhabildas Nomita A. Olson Richard K. DeFries John C. Pennington Bruce F. 《Reading and writing》2002,15(7-8):683-707
The present study examined the etiology of highreading ability in an overall sample of 350twin pairs in which at least one member of 100pairs (54 MZ, 46 DZ) had a reading compositescore one standard deviation above the sample mean. These highreaders also had significantly higher scoresthan the rest of the sample on Full Scale,Verbal and Performance IQ scores, as well as onmeasures of phoneme awareness, orthographiccoding, phonological decoding, and verbalshort-term memory. The MZ proband-wiseconcordance rate for high group membership wassignificantly higher than the DZ proband-wiseconcordance rate and further behavioralgenetic analyses corroborated that high readingability is partly due to genetic influence(h2
g = 0.55 ± 0.22). Bivariatemultiple regression analyses demonstrated thathigh phonological awareness, orthographiccoding, phonological decoding, and short-termverbal memory skills all share significantcommon genetic influence with high readingability. These results suggest that readingability and its cognitive correlates are on acontinuous distribution, with both extremes ofthe distribution being similarly heritable. They also support the hypothesis that the samecognitive processes that are associated withdyslexia are important for the development ofhigh reading ability. 相似文献
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Role of oxidative stress while controlling iron deficiency anemia during pregnancy - Indian scenario
Neeta Kumar Nomita Chandhiok Balwan S. Dhillon Pratik Kumar 《Indian journal of clinical biochemistry : IJCB》2009,24(1):5-14
Iron Deficiency anemia ranks 9th among 26 diseases with highest burden. Asia bears 71% of this global burden. Adverse maternal and birth outcome associated
with hemoglobin status renders the issue worth attention. Indian scenario has worsened over the period despite continuous
international and national efforts. This indicates some lacunae in the approach and strategies applied. Various reports state
that even with maximum effort to increase outreach and monitoring for adherence to Iron schedule, consumer’s compliance remains
abysmally low. Recent studies has pointed out biological basis of side effects (gastrointestinal complains and systemic events)
as raised oxidative stress for which iron is the key catalyst. Up till now the only target of research has been to raise hemoglobin
of pregnant women above 11gm/dl. With the reports of pregnancy specific morbidities i.e. hemorrhage and septicemia with low
hemoglobin, eclampsia, small for gestation age, gestational diabetes with higher ranges of hemoglobin, alarm is raised to
define optimum range. Use of oxidative stress as biochemical marker with different doses and schedules has been defined because
India lack information for its own population upon oxidative stress status when iron is supplemented as per current guidelines.
Studies done in India and abroad have defined that too much and too less, both may raise oxidative stress and studies of this
sort may provide biochemical scale for optimization. This review therefore has evaluated currently available Indian research
and reports to understand the need of future research area. Important findings from other countries have been incorporated
for comparison. 相似文献
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