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Praveen Sharma Sandhya Mishra Peeyush Ajmera Sandeep Mathur 《Indian journal of clinical biochemistry : IJCB》2005,20(1):145-149
As antioxidants play a protective role in the pathophysiology of diabetes and cardiovascular diseases, understanding the physiological
status of antioxidant concentration among people at high risk for developing these conditions, such as Metabolic Syndrome,
is of interest. In present study out of 187 first degree non-diabetic relatives and 192 non-diabetic spouses, 33.1% and 19.7%
were found to have metabolic syndrome respectively. Subjects with metabolic syndrome (≥3 risk factors) had poor antioxidants
status as reflected by significantly low levels of vitamin A, C & E and significantly increased (p<0.01) oxidative stress
as compared to those without metabolic syndrome. At the same time serum insulin levels and insulin resistance were found to
be significantly high (p<0.001) in metabolic syndrome. A strong positive correlation (r=0.946; p<0.001) between oxidative
stress and insulin resistance was observed in metabolic syndrome. Low levels of antioxidants and increased oxidative stress
with insulin resistance in metabolic syndrome suggests that besides therapeutic life style changes (TLC) as suggested in ATP
III guidelines inclusion of antioxidant vitamins, fruits and vegetable could be beneficial to ward off the consequences of
metabolic syndrome. 相似文献
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Chitra Upadhyaya Sandhya Mishra Peeyush Ajmera Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2004,19(2):48-52
Pregnancy is associated with increased demand of all the nutrients like Iron, Copper, Zinc etc. and deficiency of any of these
could affect pregnancy, delivery and out come of pregnancy. With this consideration, the study was conducted on 80 mothers
and newborns and 20 age matched control women. Out of 80 mothers, 34 had Iron deficiency anemia and their Hb levels were below
9.0 gm/d1. Pregnant women had significantly lower Iron and Zinc levels while Copper and Total Iron Binding Capacity (TIBC) were significantly
higher (P<0.001). Newborns had significantly elevated Iron and Zinc levels and low levels of Copper and TIBC as compared to
their mothers irrespective of Iron deficiency anemia. Micronutrient status of newborn was found to be dependent on their mother's
micronutrient status. Besides, results also suggest micronutrient interactions, which are reflected in Iron/Zinc, Iron/Copper
and Zinc/Copper ratios. In view of this, there is need for proper, adequate and balanced micronutrient supplementation during
pregnancy to affect a healthy outcome. 相似文献
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S. K. Mathur Piyush Chandra Sandhya Mishra Peeyush Ajmera Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2007,22(2):70-73
Asian Indians are known to be at a higher risk of developing T2DM, but the underlying genetic factor in this population is
still not well understood. T2DM is a complex genetic trait and assessment of disease related intermediate phenotypic traits
is an important initial step towards any systematic genomic study. Therefore, in the present study we have assessed diabetes
related intermediate phenotypic traits of insulin secretion and insulin resistance in the patients belonging to this population.
The study included 157 T2DM patients of either sex ranging in age from 45–80 years and 84 non-diabetic subjects with no family
history of diabetes, ranging in age from 45 to 75 years served as controls. Intermediate phenotypic traits studied were BMI,
W: H ratio, fasting free fatty acid level and Insulin resistance and secretion. Diabetics were found to have significantly
higher W: H ratio (p<0.001), FFA (p<0.001) and HOMA-R (p<0.001) as compared to non-diabetics. However, there was no significant
difference in their BMI and HOMA-β. There was a positive correlation between FFA level and HOMA-R among diabetics, but not
among controls. These findings suggest that in abdominal obesity FFA mediated insulin resistance is an important causative
factor underlying T2DM in this population. Moreover, comparable HOMA-β in diabetics reflects compensatory insulin hyper secretion
in these subjects. There is a need to examine relative contribution and precise nature of genetic factor in their tendency
for central obesity, free fatty acidemia and insulin resistance. 相似文献
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