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Bhupendra Pal Singh Shailendra Dwivedi Urmila Dhakad Ramesh Chandra Murthy Vimal Kumar Choubey Apul Goel Satya Narayan Sankhwar 《Indian journal of clinical biochemistry : IJCB》2016,31(1):50-56
Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/Mann–Whitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis. 相似文献
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In previous studies, we have reported first in vivo evidence of copper deposition in the choroid plexus, cognitive impairments, astrocytes swelling (Alzheimer type II cells) and astrogliosis (increase in number of astrocytes), and degenerated neurons coupled with significant increase in the hippocampus copper and zinc content in copper-intoxicated Wistar rats. Nonetheless, hippocampus iron levels were not affected by chronic copper-intoxication. Notwithstanding information on distribution of copper, zinc and iron status in different regions of brain due to chronic copper exposure remains fragmentary. In continuation with our previous study, the aim of this study was to investigate the effects of intraperitoneally injected copper lactate (0.15 mg Cu/100 g body weight) daily for 90 days on copper, zinc and iron levels in different regions of the brain using atomic absorption spectrophotometry. Copper-intoxicated group showed significantly increased cortex, cerebellum and striatum copper content (76, 46.8 and 80.7 % increase, respectively) compared to control group. However, non-significant changes were observed for the zinc and iron content in cortex, cerebellum and striatum due to chronic copper exposure. In conclusion, the current study demonstrates that chronic copper toxicity causes differential copper buildup in cortex, cerebellum and striatum region of central nervous system of male Wistar rats; signifying the critical requirement to discretely evaluate the effect of copper neurotoxicity in different brain regions, and ensuing neuropathological and cognitive dysfunctions. 相似文献
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Kulinder Pal Singh 《Resonance》2005,10(7):8-20
The excellent X-ray images produced by X-ray telescopes require the use of detectors with imaging capability at the focal
plane of the telescopes. In this concluding part of the article on experimental techniques in X-ray astronomy, I describe
many X-ray detectors that have been used over the years. These can broadly be classified into two physical types: non-dispersive
and dispersive. Traditionally the simple non-dispersive types have been used extensively in X-ray astronomy. The advancement
of solid state technologies, cryogenics, and the quality of X-ray imaging has led to many new detectors of both types. Both
the traditional and the new types of detectors are described briefly here with emphasis on principles and some technical details.
Kulinder Pal Singh is in the Department of Astronomy and Astrophysics of the Tata Institute of Fundamental Research, Mumbai.
His primary fields of research are X-ray studies of hot plasmas in stars, supernova remnants, galaxies, intergalactic medium
in clusters of galaxies, active galactic nuclei, cataclysmic variables and X-ray binaries. He is leading the development of
a soft X-ray imaging telescope for the ASTROSAT mission to be launched by India in 2007–2008.
Part 1. Imaging Telescopes,Resonance, Vol. 10, No. 5, pp. 15–23, 2005. 相似文献
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Sanyal N Pramanik SK Pal R Chowdhury A 《Journal of Zhejiang University. Science. B》2006,7(3):202-208
Two sulfonylurea herbicides, metsulfuron methyl （Ally 20 WP） and chlorimuron ethyl （Classic 25 WP） were evaluated for their dissipation bchaviour in alluvial, coastal saline and laterite soils under laboratory incubated condition at 60% water holding capacity of soils and 30 ℃ temperature was maintained. In field study herbicides were applied twice for the control of grasses, annual and perennials broad leaves weeds and sedges in rice, wheat and soybean to find out the residual fate of both the herbicides on different matrices of respective crops after harvest. Extraction and clean up methodologies for the herbicides were standardized and subsequently analyzed by HPLC. The study revealed that the half-lives of metsulfuron methyl and chlorimuron ethyl ranged from 10.75 to 13.94 d irrespective of soils and doses applied. Field trials with rice, wheat and soybean also revealed that these two herbicides could safely be recommended for application as no residues were detected in the harvest samples. 相似文献
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Anshita Aggarwal Sant Ram Abhilasha Garg Rimesh Pal Anil Bhansali Priyanka Singh Sadhna Sharma J. S. Thakur Naresh Sachdeva Sanjay Kumar Bhadada 《Indian journal of clinical biochemistry : IJCB》2021,36(1):67
We aimed to estimate metabolic bone profile in a large cohort of healthy, adult Indian population to generate reference standards of serum calcium, phosphate and alkaline phosphatase (ALP), 25 (OH) Vitamin D and iPTH, and also to find out the prevalence of Vitamin D deficiency in healthy population. Apparently healthy people in the age group of 20–80 years, residing in the union territory of Chandigarh were chosen. Fasting samples for serum calcium, phosphate, albumin, alkaline phosphatase (ALP), 25 (OH) D and iPTH were collected and were processed on the same day. We recruited 930 healthy subjects from different subsectors of Chandigarh. Final analysis was done for 915 subjects. Out of this, 530 (58%) were women and 385 (42%) were men. The study participants were divided into two groups, less than and more than 50 years for the men and pre and post-menopausal for the women. The serum calcium, phosphate, ALP and iPTH were significantly higher in the post-menopausal women compared to the pre-menopausal women. The median plasma 25 (OH) D in men and women was 12.5 ng/mL and 14.3 ng/mL, respectively. 25 (OH) D deficiency was seen in 65.4% of individuals. 25 (OH) D levels co-related negatively with iPTH levels (r = − 0.4, p < 0.0001), and showed an increasing trend with age. We have thus presented metabolic bone profile of healthy, adult north Indian population. These reference values can be used for diagnosis and monitoring of various MBDs. Vitamin D deficiency is still rampant in our population in spite of increasing awareness. 相似文献
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Mukhopadhyay M Sinha R Pal M Bhattacharyya S Dan A Roy MM 《Indian journal of clinical biochemistry : IJCB》2011,26(3):274-278
The progress of fracture union requires close monitoring. Whereas, clinical examination and radiographic studies assess the
outcome, biochemical markers like serum alkaline phosphatase and urinary hydroxyproline reflect the actual status of bone
resorption and bone formation over a short time frame. 36 patients of long bone fracture were randomly allocated for the study.
When the patient reported to the Department of Orthopedics after fracture, serum and urinary samples were collected and X-ray
of the affected part were taken. Subsequent samples were collected and X-ray taken just after management (either operative
or conservative), after 3rd, 5th, 8th and 12th week, respectively after onset of fracture. According to the course of callus
formation the patients were divided into two groups that progressed to proper union or malunion. The levels of serum alkaline
phosphatase, urinary total and free hydroxyproline levels were measured and statistically analysed and compared. A statistically
significant positive correlation between total urinary hydroxyproline excretion and serum alkaline phosphatase indicate progress
towards satisfactory union. Thus, serial monitoring of biochemical markers of bone turnover can be used as an adjunct to clinical
and radiological evidence of fracture healing. 相似文献