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1.
Franky D. Shah Rasheedunnisa Begum Bhairavi N. Vajaria Kinjal R. Patel Jayendra B. Patel Shilin N. Shukla Prabhudas S. Patel 《Indian journal of clinical biochemistry : IJCB》2011,26(4):326-334
Oral cancer has emerged as an alarming public health problem with increasing incidence and mortality rates all over the world.
Therefore, the implementation of newer screening and early detection approaches are of utmost importance which could reduce
the morbidity and mortality associated with this disease. Sensitive and specific biomarkers for oral cancer are likely to
be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. Unlike other deep cancers,
oral cancer is located in oral cavity. Hence, the direct contact between saliva and oral cancer lesion makes the measurement
of tumor markers in saliva an attractive alternative to serum and tissue testing. The DNA, RNA and protein molecules derived
from the living cancer cells can be conveniently obtained from saliva. Thus, salivary biomarkers, a non-invasive alternative
to serum and tissue-based biomarkers may be an effective modality for early diagnosis, prognostication and monitoring post
therapy status. In the current post-genomic era, various technologies provide opportunities for high-throughput approaches
to genomics and proteomics; which have been used to evaluate altered expressions of gene and protein targets in saliva of
oral cancer patients. The emerging field of salivary biomarkers has great potentials to prove its clinical significance to
combat oral cancer. Hence, we have reviewed importance of several salivary genomics and proteomics biomarkers for oral cancer. 相似文献
2.
Paula G. Purnell Parveen Ali Nurun Begum Marilyn Carter 《Early Childhood Education Journal》2007,34(6):419-424
This article investigates how instructors can utilize the integration of early literacy skills and the arts to cultivate the
appreciation and celebration of cultures in early childhood classrooms. The theoretical framework is developed through three
personal accounts establishing a rationale for the importance of a viable home to school connection for young children. Finally,
the suggested activities support the transference of theory into classroom practice. 相似文献
3.
Jannath Begum Ali Rhiannon L. Thomas Stephanie Mullen Raymond Andrew J. Bremner 《Child development》2021,92(1):21-34
Two experiments examined perceptual colocation of visual and tactile stimuli in young infants. Experiment 1 compared 4- (n = 15) and 6-month-old (n = 12) infants’ visual preferences for visual-tactile stimulus pairs presented across the same or different feet. The 4- and 6-month-olds showed, respectively, preferences for colocated and noncolocated conditions, demonstrating sensitivity to visual-tactile colocation on their feet. This extends previous findings of visual-tactile perceptual colocation on the hands in older infants. Control conditions excluded the possibility that both 6- (Experiment 1), and 4-month-olds (Experiment 2, n = 12) perceived colocation on the basis of an undifferentiated supramodal coding of spatial distance between stimuli. Bimodal perception of visual-tactile colocation is available by 4 months of age, that is, prior to the development of skilled reaching. 相似文献
4.
Suchitra Surve Shahina Begum Beena Joshi M. Ikram Khatkhatay Seema Kadam Sanjay Chauhan 《Indian journal of clinical biochemistry : IJCB》2021,36(2):167
Despite ample sunshine, 50–90% Indian children have Vitamin D deficiency (VDD). This enigma of widespread VDD needs exploration especially among under-fives as physiological variations in Vitamin D Binding Protein (VDBP) levels could be potential confounders in the interpretation of total 25-hydroxyvitamin D [25(OH)D]. However, there is scarce information about relevance of VDBP levels in under-five age group. We therefore, explored association of VDBP levels among 1–5 year old children with VDD. Serum levels of 25(OH)D, VDBP, calcium, parathyroid hormone (PTH) and alkaline phosphatase were estimated in 210 apparently healthy children in the age group of 1–5 years. VDD was defined as serum 25(OH)D levels < 20 ng/ml as per the IOM classification. VDBP levels were classified as low if levels were < 168 μg/ml as per the kit. The prevalence of VDD was 79.5% (n = 167) and VDBP levels were low in 48.6% (n = 102) of children. 25(OH)D levels correlated positively with VDBP (r = 0.298, p = 0.0001). A significant number of children (52.7%) with VDD had low VDBP (p = 0.015). and despite adequate sun exposure, 43% of children showed VDD and 56.6% had low VDPB levels. The low VDBP levels largely explain low 25OHD levels without necessarily implying VDD. It may add a new dimension for better understanding of widespread VDD among under-five children. It thus, points towards the need for redefining cut offs and complete evaluation of vitamin D status among under-fives including VDBP. 相似文献
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6.
Cheryl J. Dye Joel E. Williams Karen A. Kemper Francis A. McGuire Begum Aybar-Damali 《Educational gerontology》2013,39(11):788-798
A multidisciplinary team developed and pilot-tested a curriculum, delivered by trained lay educators, to increase self-efficacy for physical activity among elderly food stamp recipients. Curriculum development was guided by a comprehensive literature review. Process evaluation was used to revise the curriculum and to assess lay educator training and pilot test fidelity. Three hundred sixteen low-income older adults participated in curriculum development and pilot-testing activities. One hundred twenty four participants completed pretest/posttest impact evaluation surveys. The average age of participants was 75 years old with 55.28% having less than high school education. Significant increases in self-efficacy regarding walking most days (p = .0022), using exercise bands (p < .0001), being physically active to increase strength (p = .0012), being active without injury (p < .0001), being able to wear appropriate clothing and shoes (p < .0001), and getting information about community physical activity programs (p = .0007) were observed. Participants also endorsed higher ratings of general health at posttest (p < .0001). 相似文献
7.
O’Brien Beth A. Mohamed Malikka Begum Habib Yussof Nurul Taqiah Ng Siew Chin 《Reading and writing》2019,32(4):909-937
Reading and Writing - Phonological awareness is critical for early reading acquisition across alphabetic as well as non-alphabetic languages. The grain size of phonological awareness varies with... 相似文献
8.
Infants can track small groups of solid objects, and infants can respond when these quantities change. But earlier work is equivocal about whether infants can track continuous substances, such as piles of sand. Experiment 1 (N = 88) used a habituation paradigm to show infants can register changes in the size of piles of sand that they see poured from a container when there is a 1-to-4 ratio. Experiment 2 (N = 82) tested whether infants could discriminate a 1-to-2 ratio. The results demonstrate that females could discriminate the difference but males could not. These findings constitute the youngest evidence of successful quantity discriminations for a noncohesive substance and begin to characterize the nature of the representation for noncohesive entities. 相似文献
9.
Hasne Ara Begum Rokhsana Perveen Evelina Chakma Limia Dewan Rawshan Sadia Afroze 《International Journal of Inclusive Education》2019,23(1):7-22
ABSTRACTThis paper considers the challenges of promoting inclusive education in geographically isolated rural communities in Bangladesh. Inclusion is explored from both government and non-government (NGO) providers, and identifies challenges and opportunities for implementing inclusive practices. Challenges for implementing inclusion are linked to poverty, gender inequality, ethnicity, remoteness, language barriers, issues for children with disabilities, and the negative impact of climate (e.g. monsoonal flooding, landslides, and other natural calamities that beset Bangladesh on a regular basis) as well as the current humanitarian crisis with the Rohingya children now in Bangladesh. While there is sometimes a mismatch between government policy and the literature on inclusion in relation to practical implementation at the local level, opportunities for inclusion come with the dedication and passion of educators who provide teacher training about inclusive education, assistive technologies (Braille materials, hearing aids, etc.), multi-lingual education (MLE) materials, and advocacy by reaching out to parents and community members. Findings indicate that characteristics such as culture, the development of local resources, and the climate of the local context need to be considered in developing relevant inclusive policy to enact effective geographical inclusive practices in rural Bangladeshi communities. 相似文献
10.
Mst. Marium Begum Zakia Sultana Md. Ershad Ali Md. Safkath Ibne Jami Proma Khondkar Md. Masuduzzaman Khan Md. Mominul Haque 《Indian journal of clinical biochemistry : IJCB》2014,29(4):452-461
High blood glucose level, elevated level of liver enzyme, necrosis and shrinkage of islets of Langerhans has been implicated in the pathogenesis of type 2 diabetes. High blood glucose cause oxidative stress, production of free radical as well as elevated SGPT and SGOT level. Both glibenclamide and simvastatin in fixed dose used as antihyperglycemic antidyslipidemic and antioxidative agents for type 2 diabetes treatment. This study therefore aimed to evaluate the antihyperglycemic, antidyslipidemic and antioxidative effect of fixed dose combination of glibenclamide (0.6 mg/70 kg body weight) and simvastatin (5 mg/70 kg body weight) on long term alloxan induced diabetic rats with cardiovascular disease using various diagnostic kits as a parameter of phamacotherapeutic and pharmacological effect. The study was carried out using 96 Swiss Albino male rats weighing about 200–220 g. Combination therapy induced a significant decrease in blood glucose level in alloxan induced diabetic rats, from 33.75 ± 1.65 to 5.80 ± 0.07 mmol/l 2 h after last dose administration, after 4 weeks treatment. In case of dyslipidemic effect, combination therapy reduced total cholesterol (45 %), triglyceride (36 %) and low density lipoprotein-cholesterol (32 %) levels significantly and increased high density lipoprotein-cholesterol level (57 %) in comparison with their respective diabetic control groups. Results of this study showed that combination therapy effectively decreased SGPT (ALAT) (55 %) and SGOT (ASAT) (51 %) in comparison with diabetic control group. It was also observed that catalase and superoxide dismutase enzyme activity was increased by 58 and 91 % respectively in comparison with diabetic control group after 4 weeks treatment with combination of both drugs. In conclusion, these findings of combination therapy (glibenclamide and simvastatin) on alloxan induced diabetes in rats are significantly better than monotherapy using single drug. The results of the present study suggest that, combination of the fixed dose of glibenclamide and simvastatin might be efficacious in patients with diabetic dyslipidemia and increased oxidative stress. Furthermore, this combination therapy offer dosage convenience to the patients and by virtue of its dual mode of action might be a useful addition to the therapeutic armamentarium for patients with diabetic dyslipidemia and oxidative stress. 相似文献