排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Fouzia Rashid M. Kaleem Sheema B. Bano 《Indian journal of clinical biochemistry : IJCB》2005,20(1):109-114
The present study is related to the comparative effects of fish oil and olive oil supplementation on gentamicin induced nephrotoxicity
in rats. Three treatment groups (Pretrement, Co-treatment and post treatment) were chosen for the study. Nephrotoxicity in
rats was induced by intraperitonial administration of gentamicin (80 mg/kg/d) for 3,5,7,10,& 12 consecutive days. The animals
were sacrificed 12 hrs after last treatment in each group. The maximum nephrotoxicity was developed on 10 days treatment of
gentamicin. For each group a control group was taken without any oil or gentamicin treatment. Beneficial effects of oils were
evidenced by reduced serum urea and creatinine concentrations in the group receiving oils compared to the non oil treatment
animals receiving gentamicin only. Further, the changed values of alkaline phosphatase and acid phosphatase activity retumed
to normal in kidney and liver tissue homogenates after fish and olive oil treatment. In this study, it was found that co-treatment
of fish and olive oil is more effective antagonist of gentamicin induced nephrotoxicity. However fish oil was found to be
more effective. Hypercholesteromia associated with gentamicin induced nephrotoxicity is also lowered by oil supplementations.
The beneficial effects of these oils are due to counteracting effect of the biochemical alterations induced by the drug. 相似文献
1