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Harleen Mangat Tajamul Hussain C Sundaram MP JS Anandaraj 《Indian journal of clinical biochemistry : IJCB》2002,17(2):74-79
Poly A RNA status and itsin vitro translation in a rabbit reticulolysate cell free system, were assessed in the skeletal muscle of young boys with Duchenne
muscular dystrophy. Compared to normals there is a significant 48% increase in poly A RNA content of dystrophic muscle and
its translatability was increased by 56% based on35S methionine incorporation into total protein systhesised. Immunoprecipitation of the translated products with monospecific
antibodies showed that there is a 2.6 fold and a 2 fold increase in m and μ calpains respectively. This underlines the importance
of both synthetic and degenerative activities in the early pathology in DMD muscle. 相似文献
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In this section of Resonance, we invite readers to pose questions likely to be raised in a classroom situation. We may suggest strategies for dealing with them, or invite responses, or both. "Classroom" is equally a forum for raising broader issues and sharing personal experiences and viewpoints on matters related to teaching and learning science. 相似文献
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The last decade has seen a growing recognition amongst international donors, development agencies, non-government organisations and academics of the vital role education can play in bringing about recovery following violent conflict, natural disaster and other crises. This has led to the development of increasingly targeted and sophisticated programme planning and management tools, for use by government ministries, UN agencies and non-governmental organisations in fragile contexts. Drawing on the 2010 independent study of UNICEF's Education in Emergencies and Post-Conflict Transition Programme, this paper explores the transformative role education can play in post-conflict recovery. It argues that while basic education assistance can have a catalytic role in helping states during the early stages of a transition out of violent conflict, there is the need for a better understanding of its role in building peace at the national, sub-national and community levels. The paper also argues for the development of a solid evidence base to inform policy and practice at all national, regional and community levels so as to demonstrate conclusively the important role played by education during and in the aftermath of conflict. 相似文献
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This paper analyses how knowledge-based practices adopted by innovation intermediaries enable them to generate value for themselves when collaborating with their clients. While the literature focuses on value creation for their client organisations, little is known about how innovation intermediaries create internal value even though this is essential for ensuring their long-term survival and sustaining their key facilitating role in the innovation system. This understudied issue is explored using empirical evidence from a sub-set of innovation intermediaries, Research and Technology Organisations (RTOs). The results indicate that by capitalising on existing knowledge vested in employees and collaborators as well as understanding and shaping the knowledge base of the innovation ecosystem, innovation intermediaries generate internal value from their involvement in collaborative innovation, which range from different financial to non-financial types of value. Implications for intermediaries, their collaborators and for policymakers are then discussed. 相似文献
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Jomo Kwame Sundaram 《Inter-Asia Cultural Studies》2016,17(1):27-32
The 1955 Bandung Afro-Asian solidarity conference symbolized the end of the colonial era and the beginning of new relations between the former colonial powers that had industrialized and the former colonies subsequently variously referred to as the developing countries, Third World or South. These changing relations also involved new discourses and modes of analysis. The nature and pattern of inequalities have also changed significantly over time, including during the recent period. Despite high levels of national level inequalities, about two thirds of overall economic inequality are due to disparities among countries. But the determinants of changing inequalities have also changed significantly as economic relations at both national and international levels have changed with economic, social and political transformations. In recent years, the ascendant developmentalist discourse of the 1960s and 1970s was undermined by the rise of conservative market fundamentalism. The discourse of development has continued to change as reflected by the lines and terms of conflict and contention. The four Development Decades of the late 20th century gave way to the Millennium Development Goals of the last decade and a half. The struggle to elaborate the Sustainable Development Goals for the next period is the most recent manifestation of this ongoing struggle. 相似文献
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Vanita Sundaram 《Gender and education》2013,25(7):889-906
Youth violence is a topic of increasing global concern. Research has primarily focused on young people's responses to existing definitions of violence in seeking to understand how best to develop violence prevention. Little work has explored how young people themselves define violence and the factors which influence their acceptance, and use, of violent behaviour. The present study investigated young people's understandings of what constitutes violence, their acceptance of violence and justifications made for doing so. The study was distinct in its focus on young people's characterisations of violence. The findings revealed that gender norms mediate understandings of what constitutes violence and discourses around the perceived acceptability of violence. Particular forms of violence were clearly identified as being more acceptable and ‘deserved’ than others and young people's perceptions were shaped by their understandings of appropriate and normative gender behaviour. 相似文献
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Kevin Luongo Angela Holton Ajeet Kaushik Paige Spence Beng Ng Robert Deschenes Shankar Sundaram Shekhar Bhansali 《Biomicrofluidics》2013,7(3)
In this paper, we report the design, fabrication, and testing of a lab-on-a-chip based microfluidic device for application of trapping and measuring the dielectric properties of microtumors over time using electrical impedance spectroscopy (EIS). Microelectromechanical system (MEMS) techniques were used to embed opposing electrodes onto the top and bottom surfaces of a microfluidic channel fabricated using Pyrex substrate, chrome gold, SU-8, and polydimethylsiloxane. Differing concentrations of cell culture medium, differing sized polystyrene beads, and MCF-7 microtumor spheroids were used to validate the designs ability to detect background conductivity changes and dielectric particle diameter changes between electrodes. The observed changes in cell medium concentrations demonstrated a linear relation to extracted solution resistance (Rs), while polystyrene beads and multicell spheroids induced changes in magnitude consistent with diameter increase. This design permits optical correlation between electrical measurements and EIS spectra. 相似文献
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Shrilekha Sairam Suhasini Domalapalli Sundaram Muthu Jayanthi Swaminathan Vivek A. Ramesh Lalitha Sekhar Palak Pandeya Udhaya Balasubramaniam 《Indian journal of clinical biochemistry : IJCB》2014,29(3):290-297
Clinical reference intervals among Indian population are poorly defined. Therefore, there is an urgent need to establish local clinical laboratory reference intervals for healthy Indian population. The present study aimed to identify the 95 % reference interval for hematological and biochemical parameters in apparently healthy Indian population. We undertook a multicentric cross-sectional study conducted at Apollo Hospitals Educational and Research Foundation across India. Of which 10,665 reference individuals identified as healthy by physicians. The 95 % of the reference distribution was estimated using 2.5th and 97.5th percentile reference limits. The 95 % reference intervals for hemoglobin (Males: 12.3–17 g/dL; Females: 9.9–14.3 g/dL), platelet count (Males: 1.3–3.8; Females: 1.3–4.2 Lakhs/µL), erythrocyte sedimentation rate (Males: 2–22; Females: 4–55 mm/h), serum uric acid in males: 3.5–8.2 mg/dL, gamma glutamyl transferase (Males: 13–61 U/L), fasting blood glucose (Males: 78–110 mg/dL), total cholesterol (Males: 115–254 mg/dL), low density lipoprotein (Males: 60–176 mg/dL) and triglycerides (Males: 55–267 mg/dL, Females: 52–207 mg/dL) were different from currently used reference values. Additionally need for gender based partitioning were observed for triglycerides and gamma glutamyl transferase. The observed findings are of clinical significance and it needs to be validated with additional community based studies. 相似文献