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Apurva Srivastava Neena Srivastava Balraj Mittal 《Indian journal of clinical biochemistry : IJCB》2016,31(4):361-371
Numerous classical genetic studies have proved that genes are contributory factors for obesity. Genes are directly responsible for obesity associated disorders such as Bardet–Biedl and Prader–Willi syndromes. However, both genes as well as environment are associated with obesity in the general population. Genetic epidemiological approaches, particularly genome-wide association studies, have unraveled many genes which play important roles in human obesity. Elucidation of their biological functions can be very useful for understanding pathobiology of obesity. In the near future, further exploration of obesity genetics may help to develop useful diagnostic and predictive tests for obesity treatment. 相似文献
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R. Kumar R. Kapoor B. Mittal A. Kumar R. D. Mittal 《Indian journal of clinical biochemistry : IJCB》2003,18(2):209-215
Metabolic abnormalities were investigated in 44 stone patients with first time (group 1) and 56 with 2 times stone formation
(group 2), and in 25 normal individuals. 24hr urine was analysed spectrophotometrically for oxalate, calcium, magnesium, citrate,
uric acid, phosphate and creatinine. Hypocitraturia and hyperoxaluria were the common abnormalities in the stone formers.
Stone patients had significantly higher urinary oxalate, calcium and uric acid and lower phosphate than normal individuals.
Citrate/calcium and magnesium/calcium ratio were significantly high in normal individuals than stone formers. Patients in
group 2 excreted significantly higher urinary calcium and lower citrate that patients in group 1. Citrate/calcium ratio was
higher in group 1 than group 2. Hypocitraturia, hyperoxaluria, hypercalciuria and increased citrate/calcium and magnesium/calcium
ratio seem to be an essential risk factor for stone formation. Patients with recurrent stone formation could be distinguished
from patients with first time stone formation on the basis of urinary calcium and citrate. 相似文献
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Davinder Mittal 《Resonance》1997,2(7):64-66
A simple chemical process is described for extracting amorphous silica from rice husk. 相似文献
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In Part 1 of this article, we had introduced the reader to some basic concepts of fractals and some operational algorithms to characterize them. We had also pointed out and clarified some common misconceptions about fractals. In this part we apply the fractal concepts to large-scale structures in the Universe. In particular we discuss the claim by some investigators that the distribution of galaxies in the Universe is a fractal. This is contrary to the standard view that the Universe is homogeneous and isotropic on large scales. Also discussed is the controversy as to whether the matter distribution in the Universe is a fractal on large-scales. 相似文献
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During the last decade it has been argued by some investigators that the distribution of galaxies in the Universe is a fractal.
This is contrary to the standard view that the Universe is homogeneous and isotropic on large scales. In this article, the
basic concepts of fractals and their characterization are introduced with the help of simple examples. The applications of
these concepts in the context of cosmology will be discussed in the second part.
A K Mittal is currently a visiting scientist at Harish-Chandra Research Institute, Allahabad, on leave from the University
of Allahabad. His research interests include chaos, fractals and their applications, partleularly in cosmology and in weather
prodiction.
T H Seshadri is at the Department of Physics and Astrophysics, University of Delhi. He is presently on lien from Harish-Chandra
Research Institute, Allahabad. Areas of his interest include cosmic microwave background radiation, large scale structures
in the Universe and application of fractals in these. 相似文献
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Surabhi Mittal Subash Surendran Padmaja Anurag Ajay 《The Journal of Agricultural Education and Extension》2018,24(5):393-418
Purpose: The key informants in a village setup were studied to understand the existing social and knowledge systems of farmers, their structure, and relationships between different actors. The purpose is to identify different channels of information and use them as a means to disseminate agricultural technologies and related information to farmers.
Design: We use the network map analysis in a case study approach as a tool to demonstrate the linkages between the key actors and stakeholders in the information network of farmers.
Findings: The government institutions are well networked among themselves but have limited interactions with non-government sources. Farmers in Bihar have strong linkages with few network actors, who are important nodes in the social knowledge network. The study showed heterogeneity and complexity in the network shape and structure across different districts.
Practical Implications: Knowledge networks and social networks are the drivers of information sharing and play a significant role in the diffusion of agricultural technology and related knowledge. Understanding these networks provides a platform for introducing the agricultural technologies and getting connected to a wider group of farming communities.
Theoretical Implications: The study shows that the network is formed by different actors and their role determine the nature and shape of the network. Knowledge of this heterogeneity is important in designing or revamping agricultural information systems.
Originality: Information and knowledge networks are least explored in the agricultural information dissemination process. Some studies have shown the role of actors and social networks, but this study uniquely explores and presents the heterogeneity of these networks. 相似文献
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Ekta Bansal Navpreet Kaur Naveen Mittal 《Indian journal of clinical biochemistry : IJCB》2018,33(4):456-460
Traditionally small intestinal biopsy has been considered a gold standard for the diagnosis of celiac disease (CD). But now data has shown that serological markers like anti-tissue-transglutaminase antibodies (tTGA) can be used to make the diagnosis with great sensitivity and specificity. The objective of the present study was to evaluate whether patients with high probability of CD and high titre of tTGA, have a high probability of intestinal damage and may not require biopsy for final diagnosis. All the cases with tTGA levels ≥15 IU/ml and who subsequently underwent biopsy from July 2010 to June 2013 were selected. Histopathological findings graded as per Marsh classification were correlated with serum tTGA levels. Grade 3 lesions were considered diagnostic for the disease. Out of total 731 patients 470 had serum tTGA levels >100 IU/ml and 261 patients had <100 IU/ml. Highest levels of tTGA (219.3 IU/ml) were seen in grade 3c which was >12 times the normal cutoff value. Mean serum tTGA in higher histological grade i.e. 3 (3a, 3b, 3c) was 186.7 IU/ml (>12 times the normal cut off value) as compared to grade 1 which was 108.9 IU/ml (>7 times the normal cut off value). Using a tTGA cutoff value of 70 IU/ml, sensitivity was found to be 83.9% while specificity was 56.10% with an overall accuracy of 77.7%. This study confirms that a small intestinal biopsy is not always necessary for the diagnosis of CD in symptomatic patients with high tTGA levels (>70 IU/ml). 相似文献
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Katie J. Thralls Suneeta Godbole Todd M. Manini Eileen Johnson Loki Natarajan Jacqueline Kerr 《Journal of sports sciences》2013,31(20):2309-2317
ABSTRACTThis study compared five different methods for analyzing accelerometer-measured physical activity (PA) in older adults and assessed the relationship between changes in PA and changes in physical function and depressive symptoms for each method. Older adult females (N = 144, Mage = 83.3 ± 6.4yrs) wore hip accelerometers for six days and completed measures of physical function and depressive symptoms at baseline and six months. Accelerometry data were processed by five methods to estimate PA: 1041 vertical axis cut-point, 15-second vector magnitude (VM) cut-point, 1-second VM algorithm (Activity Index (AI)), machine learned walking algorithm, and individualized cut-point derived from a 400-meter walk. Generalized estimating equations compared PA minutes across methods and showed significant differences between some methods but not others; methods estimated 6-month changes in PA ranging from 4 minutes to over 20 minutes. Linear mixed models for each method tested associations between changes in PA and health. All methods, except the individualized cut-point, had a significant relationship between change in PA and improved physical function and depressive symptoms. This study is among the first to compare accelerometry processing methods and their relationship to health. It is important to recognize the differences in PA estimates and relationship to health outcomes based on data processing method.Abbreviation: Machine Learning (ML); Short Physical Performance Battery (SPPB); Center of Epidemiologic Studies Depression Scale (CES-D); Physical Activity (PA); Activity Index (AI); Activities of Daily Living (ADL) 相似文献